These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

189 related articles for article (PubMed ID: 18305375)

  • 1. Involvement of hepatocyte nuclear factor 4 alpha in transcriptional regulation of the human pregnane X receptor gene in the human liver.
    Iwazaki N; Kobayashi K; Morimoto K; Hirano M; Kawashima S; Furihata T; Chiba K
    Drug Metab Pharmacokinet; 2008; 23(1):59-66. PubMed ID: 18305375
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Rifampicin induction of CYP3A4 requires pregnane X receptor cross talk with hepatocyte nuclear factor 4alpha and coactivators, and suppression of small heterodimer partner gene expression.
    Li T; Chiang JY
    Drug Metab Dispos; 2006 May; 34(5):756-64. PubMed ID: 16455805
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The nuclear receptors constitutive androstane receptor and pregnane X receptor cross-talk with hepatic nuclear factor 4alpha to synergistically activate the human CYP2C9 promoter.
    Chen Y; Kissling G; Negishi M; Goldstein JA
    J Pharmacol Exp Ther; 2005 Sep; 314(3):1125-33. PubMed ID: 15919766
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Positive and negative regulation of human hepatic hydroxysteroid sulfotransferase (SULT2A1) gene transcription by rifampicin: roles of hepatocyte nuclear factor 4alpha and pregnane X receptor.
    Fang HL; Strom SC; Ellis E; Duanmu Z; Fu J; Duniec-Dmuchowski Z; Falany CN; Falany JL; Kocarek TA; Runge-Morris M
    J Pharmacol Exp Ther; 2007 Nov; 323(2):586-98. PubMed ID: 17687072
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Lower expression of HNF4α and PGC1α might impair rifampicin-mediated CYP3A4 induction under conditions where PXR is overexpressed in human fetal liver cells.
    Takezawa T; Matsunaga T; Aikawa K; Nakamura K; Ohmori S
    Drug Metab Pharmacokinet; 2012; 27(4):430-8. PubMed ID: 22333269
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The xenobiotic-sensing nuclear receptors pregnane X receptor, constitutive androstane receptor, and orphan nuclear receptor hepatocyte nuclear factor 4alpha in the regulation of human steroid-/bile acid-sulfotransferase.
    Echchgadda I; Song CS; Oh T; Ahmed M; De La Cruz IJ; Chatterjee B
    Mol Endocrinol; 2007 Sep; 21(9):2099-111. PubMed ID: 17595319
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Inhibition of CYP3A4 expression by ketoconazole is mediated by the disruption of pregnane X receptor, steroid receptor coactivator-1, and hepatocyte nuclear factor 4alpha interaction.
    Lim YP; Kuo SC; Lai ML; Huang JD
    Pharmacogenet Genomics; 2009 Jan; 19(1):11-24. PubMed ID: 19077665
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Hepatocyte nuclear factor 4α regulates the expression of the murine pyruvate carboxylase gene through the HNF4-specific binding motif in its proximal promoter.
    Chavalit T; Rojvirat P; Muangsawat S; Jitrapakdee S
    Biochim Biophys Acta; 2013 Oct; 1829(10):987-99. PubMed ID: 23665043
    [TBL] [Abstract][Full Text] [Related]  

  • 9. MicroRNA-561 promotes acetaminophen-induced hepatotoxicity in HepG2 cells and primary human hepatocytes through downregulation of the nuclear receptor corepressor dosage-sensitive sex-reversal adrenal hypoplasia congenital critical region on the X chromosome, gene 1 (DAX-1).
    Li M; Yang Y; He ZX; Zhou ZW; Yang T; Guo P; Zhang X; Zhou SF
    Drug Metab Dispos; 2014 Jan; 42(1):44-61. PubMed ID: 24104199
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Role of the hepatocyte nuclear factor 4alpha in control of the pregnane X receptor during fetal liver development.
    Kamiya A; Inoue Y; Gonzalez FJ
    Hepatology; 2003 Jun; 37(6):1375-84. PubMed ID: 12774017
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Suppression of the pregnane X receptor during endoplasmic reticulum stress is achieved by down-regulating hepatocyte nuclear factor-4α and up-regulating liver-enriched inhibitory protein.
    Vachirayonsti T; Ho KW; Yang D; Yan B
    Toxicol Sci; 2015 Apr; 144(2):382-92. PubMed ID: 25616597
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4.
    Tirona RG; Lee W; Leake BF; Lan LB; Cline CB; Lamba V; Parviz F; Duncan SA; Inoue Y; Gonzalez FJ; Schuetz EG; Kim RB
    Nat Med; 2003 Feb; 9(2):220-4. PubMed ID: 12514743
    [TBL] [Abstract][Full Text] [Related]  

  • 13. HNF4α improves hepatocyte regeneration by upregulating PXR.
    Qiu S; Pan Y; Cui Y; Li M; Yue T; Pu S; Zhang Q; Wang M
    FASEB J; 2024 Jul; 38(14):e23830. PubMed ID: 39072875
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Liganded pregnane X receptor represses the human sulfotransferase SULT1E1 promoter through disrupting its chromatin structure.
    Kodama S; Hosseinpour F; Goldstein JA; Negishi M
    Nucleic Acids Res; 2011 Oct; 39(19):8392-403. PubMed ID: 21764778
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The far and distal enhancers in the CYP3A4 gene co-ordinate the proximal promoter in responding similarly to the pregnane X receptor but differentially to hepatocyte nuclear factor-4alpha.
    Liu FJ; Song X; Yang D; Deng R; Yan B
    Biochem J; 2008 Jan; 409(1):243-50. PubMed ID: 17764444
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Involvement of hepatocyte nuclear factor 4alpha in the different expression level between CYP2C9 and CYP2C19 in the human liver.
    Kawashima S; Kobayashi K; Takama K; Higuchi T; Furihata T; Hosokawa M; Chiba K
    Drug Metab Dispos; 2006 Jun; 34(6):1012-8. PubMed ID: 16540586
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Induction of human CYP2A6 is mediated by the pregnane X receptor with peroxisome proliferator-activated receptor-gamma coactivator 1alpha.
    Itoh M; Nakajima M; Higashi E; Yoshida R; Nagata K; Yamazoe Y; Yokoi T
    J Pharmacol Exp Ther; 2006 Nov; 319(2):693-702. PubMed ID: 16857725
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4alpha.
    Ferguson SS; Chen Y; LeCluyse EL; Negishi M; Goldstein JA
    Mol Pharmacol; 2005 Sep; 68(3):747-57. PubMed ID: 15933212
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The pregnane X receptor down-regulates organic cation transporter 1 (SLC22A1) in human hepatocytes by competing for ("squelching") SRC-1 coactivator.
    Hyrsova L; Smutny T; Carazo A; Moravcik S; Mandikova J; Trejtnar F; Gerbal-Chaloin S; Pavek P
    Br J Pharmacol; 2016 May; 173(10):1703-15. PubMed ID: 26920453
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Involvement of ESE-3, epithelial-specific ETS factor family member 3, in transactivation of the ABCB1 gene via pregnane X receptor in intestine-derived LS180 cells but not in liver-derived HepG2 cells.
    Kameyama N; Kobayashi K; Shimizu S; Yamasaki Y; Endo M; Hashimoto M; Furihata T; Chiba K
    Drug Metab Pharmacokinet; 2016 Oct; 31(5):340-348. PubMed ID: 27567379
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.