These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
6. Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate γ-secretase function in generating Alzheimer-causing Aβ peptides. Liu L; Lauro BM; Wolfe MS; Selkoe DJ J Biol Chem; 2021; 296():100393. PubMed ID: 33571524 [TBL] [Abstract][Full Text] [Related]
7. Modulation of γ-secretase activity by multiple enzyme-substrate interactions: implications in pathogenesis of Alzheimer's disease. Svedružić ZM; Popović K; Smoljan I; Sendula-Jengić V PLoS One; 2012; 7(3):e32293. PubMed ID: 22479317 [TBL] [Abstract][Full Text] [Related]
8. Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi. Xia W; Zhang J; Ostaszewski BL; Kimberly WT; Seubert P; Koo EH; Shen J; Selkoe DJ Biochemistry; 1998 Nov; 37(47):16465-71. PubMed ID: 9843412 [TBL] [Abstract][Full Text] [Related]
9. Familial Alzheimer's disease mutations in amyloid protein precursor alter proteolysis by γ-secretase to increase amyloid β-peptides of ≥45 residues. Devkota S; Williams TD; Wolfe MS J Biol Chem; 2021; 296():100281. PubMed ID: 33450230 [TBL] [Abstract][Full Text] [Related]
10. Decreased Abeta secretion by cells expressing familial Alzheimer's disease-linked mutant presenilin 1. Shimojo M; Sahara N; Murayama M; Ichinose H; Takashima A Neurosci Res; 2007 Mar; 57(3):446-53. PubMed ID: 17210196 [TBL] [Abstract][Full Text] [Related]
11. Calpain Activation in Alzheimer's Model Mice Is an Artifact of APP and Presenilin Overexpression. Saito T; Matsuba Y; Yamazaki N; Hashimoto S; Saido TC J Neurosci; 2016 Sep; 36(38):9933-6. PubMed ID: 27656030 [TBL] [Abstract][Full Text] [Related]
12. Presenilin 1 transgene addition to amyloid precursor protein overexpressing transgenic rats increases amyloid beta 42 levels and results in loss of memory retention. Agca C; Klakotskaia D; Schachtman TR; Chan AW; Lah JJ; Agca Y BMC Neurosci; 2016 Jul; 17(1):46. PubMed ID: 27388605 [TBL] [Abstract][Full Text] [Related]
13. Dual effects of familial Alzheimer's disease mutations (D7H, D7N, and H6R) on amyloid β peptide: correlation dynamics and zinc binding. Xu L; Chen Y; Wang X Proteins; 2014 Dec; 82(12):3286-97. PubMed ID: 25137638 [TBL] [Abstract][Full Text] [Related]
14. Differential regulation of amyloid precursor protein/presenilin 1 interaction during Aβ40/42 [corrected] production detected using fusion constructs. Sato N; Okochi M; Shinohara M; Thinakaran G; Takeda S; Fukumori A; Shinohara-Noma M; Mori-Ueda M; Hamada H; Takeda M; Rakugi H; Morishita R PLoS One; 2012; 7(11):e48551. PubMed ID: 23152781 [TBL] [Abstract][Full Text] [Related]
15. Distinguishable effects of presenilin-1 and APP717 mutations on amyloid plaque deposition. Ishii K; Lippa C; Tomiyama T; Miyatake F; Ozawa K; Tamaoka A; Hasegawa T; Fraser PE; Shoji S; Nee LE; Pollen DA; St George-Hyslop PH; Ii K; Ohtake T; Kalaria RN; Rossor MN; Lantos PL; Cairns NJ; Farrer LA; Mori H Neurobiol Aging; 2001; 22(3):367-76. PubMed ID: 11378241 [TBL] [Abstract][Full Text] [Related]
16. Aggregation and catabolism of disease-associated intra-Abeta mutations: reduced proteolysis of AbetaA21G by neprilysin. Betts V; Leissring MA; Dolios G; Wang R; Selkoe DJ; Walsh DM Neurobiol Dis; 2008 Sep; 31(3):442-50. PubMed ID: 18602473 [TBL] [Abstract][Full Text] [Related]
17. Nuclear translocation uncovers the amyloid peptide Aβ42 as a regulator of gene transcription. Barucker C; Harmeier A; Weiske J; Fauler B; Albring KF; Prokop S; Hildebrand P; Lurz R; Heppner FL; Huber O; Multhaup G J Biol Chem; 2014 Jul; 289(29):20182-91. PubMed ID: 24878959 [TBL] [Abstract][Full Text] [Related]
18. Deposition of C-terminally truncated Aβ species Aβ37 and Aβ39 in Alzheimer's disease and transgenic mouse models. Reinert J; Richard BC; Klafki HW; Friedrich B; Bayer TA; Wiltfang J; Kovacs GG; Ingelsson M; Lannfelt L; Paetau A; Bergquist J; Wirths O Acta Neuropathol Commun; 2016 Mar; 4():24. PubMed ID: 26955942 [TBL] [Abstract][Full Text] [Related]
20. Proteomic identification of specifically carbonylated brain proteins in APP(NLh)/APP(NLh) × PS-1(P264L)/PS-1(P264L) human double mutant knock-in mice model of Alzheimer disease as a function of age. Sultana R; Robinson RA; Di Domenico F; Abdul HM; St Clair DK; Markesbery WR; Cai J; Pierce WM; Butterfield DA J Proteomics; 2011 Oct; 74(11):2430-40. PubMed ID: 21726674 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]