BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

316 related articles for article (PubMed ID: 18321097)

  • 1. Minimal pharmacophoric elements and fragment hopping, an approach directed at molecular diversity and isozyme selectivity. Design of selective neuronal nitric oxide synthase inhibitors.
    Ji H; Stanton BZ; Igarashi J; Li H; Martásek P; Roman LJ; Poulos TL; Silverman RB
    J Am Chem Soc; 2008 Mar; 130(12):3900-14. PubMed ID: 18321097
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovery of highly potent and selective inhibitors of neuronal nitric oxide synthase by fragment hopping.
    Ji H; Li H; Martásek P; Roman LJ; Poulos TL; Silverman RB
    J Med Chem; 2009 Feb; 52(3):779-97. PubMed ID: 19125620
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Design of selective neuronal nitric oxide synthase inhibitors for the prevention and treatment of neurodegenerative diseases.
    Silverman RB
    Acc Chem Res; 2009 Mar; 42(3):439-51. PubMed ID: 19154146
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Potent and selective conformationally restricted neuronal nitric oxide synthase inhibitors.
    Gómez-Vidal JA; Martásek P; Roman LJ; Silverman RB
    J Med Chem; 2004 Jan; 47(3):703-10. PubMed ID: 14736250
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structure-guided design of selective inhibitors of neuronal nitric oxide synthase.
    Huang H; Li H; Martásek P; Roman LJ; Poulos TL; Silverman RB
    J Med Chem; 2013 Apr; 56(7):3024-32. PubMed ID: 23451760
    [TBL] [Abstract][Full Text] [Related]  

  • 6. N(omega)-Nitroarginine-containing dipeptide amides. Potent and highly selective inhibitors of neuronal nitric oxide synthase.
    Huang H; Martasek P; Roman LJ; Masters BS; Silverman RB
    J Med Chem; 1999 Aug; 42(16):3147-53. PubMed ID: 10447959
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Hydroxyethylene isosteres of selective neuronal nitric oxide synthase inhibitors.
    Erdal EP; Martásek P; Roman LJ; Silverman RB
    Bioorg Med Chem; 2007 Sep; 15(18):6096-108. PubMed ID: 17614291
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Pharmacophore and QSAR Modeling of Neuronal Nitric Oxide Synthase Ligands and Subsequent Validation and In Silico Search for New Scaffolds.
    Suaifan G; Shehadeh M; Al-Ijel H; Al-Jamal KT; Taha M
    Med Chem; 2016; 12(4):371-93. PubMed ID: 26427928
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Selective inhibition of neuronal nitric oxide synthase by N omega-nitroarginine-and phenylalanine-containing dipeptides and dipeptide esters.
    Silverman RB; Huang H; Marletta MA; Martasek P
    J Med Chem; 1997 Aug; 40(18):2813-7. PubMed ID: 9288162
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structure-based design, synthesis, and biological evaluation of lipophilic-tailed monocationic inhibitors of neuronal nitric oxide synthase.
    Xue F; Huang J; Ji H; Fang J; Li H; Martásek P; Roman LJ; Poulos TL; Silverman RB
    Bioorg Med Chem; 2010 Sep; 18(17):6526-37. PubMed ID: 20673724
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Structure-based design and synthesis of N(omega)-nitro-L-arginine-containing peptidomimetics as selective inhibitors of neuronal nitric oxide synthase. Displacement of the heme structural water.
    Seo J; Igarashi J; Li H; Martasek P; Roman LJ; Poulos TL; Silverman RB
    J Med Chem; 2007 May; 50(9):2089-99. PubMed ID: 17425297
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Phenylpyrrole derivatives as neural and inducible nitric oxide synthase (nNOS and iNOS) inhibitors.
    López Cara LC; Camacho ME; Carrión MD; Tapias V; Gallo MA; Escames G; Acuña-Castroviejo D; Espinosa A; Entrena A
    Eur J Med Chem; 2009 Jun; 44(6):2655-66. PubMed ID: 19117642
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structures of the neuronal and endothelial nitric oxide synthase heme domain with D-nitroarginine-containing dipeptide inhibitors bound.
    Flinspach M; Li H; Jamal J; Yang W; Huang H; Silverman RB; Poulos TL
    Biochemistry; 2004 May; 43(18):5181-7. PubMed ID: 15122883
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
    Wang HY; Qin Y; Li H; Roman LJ; Martásek P; Poulos TL; Silverman RB
    J Med Chem; 2016 May; 59(10):4913-25. PubMed ID: 27050842
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Aromatic reduced amide bond peptidomimetics as selective inhibitors of neuronal nitric oxide synthase.
    Hah JM; Martásek P; Roman LJ; Silverman RB
    J Med Chem; 2003 Apr; 46(9):1661-9. PubMed ID: 12699384
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Selective monocationic inhibitors of neuronal nitric oxide synthase. Binding mode insights from molecular dynamics simulations.
    Huang H; Ji H; Li H; Jing Q; Labby KJ; Martásek P; Roman LJ; Poulos TL; Silverman RB
    J Am Chem Soc; 2012 Jul; 134(28):11559-72. PubMed ID: 22731813
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Recent advances toward improving the bioavailability of neuronal nitric oxide synthase inhibitors.
    Huang H; Silverman RB
    Curr Top Med Chem; 2013; 13(7):803-12. PubMed ID: 23578024
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Reduced amide bond peptidomimetics. (4S)-N-(4-amino-5-[aminoakyl]aminopentyl)-N'-nitroguanidines, potent and highly selective inhibitors of neuronal nitric oxide synthase.
    Hah JM; Roman LJ; Martásek P; Silverman RB
    J Med Chem; 2001 Aug; 44(16):2667-70. PubMed ID: 11472219
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis and evaluation of dipeptide amides containing N omega-nitroarginine and D-2,4-diaminobutyric acids as inhibitors of neuronal nitric oxide synthase.
    Huang H; Martásek P; Roman LJ; Silverman RB
    J Enzyme Inhib; 2001; 16(3):233-9. PubMed ID: 11697043
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Screening of novel and selective inhibitors for neuronal nitric oxide synthase (nNOS) via structure-based drug design techniques.
    Boumezber S; Yelekçi K
    J Biomol Struct Dyn; 2023 May; 41(8):3607-3629. PubMed ID: 35322764
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.