BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

178 related articles for article (PubMed ID: 18323857)

  • 1. NEDD8 acts as a 'molecular switch' defining the functional selectivity of VHL.
    Russell RC; Ohh M
    EMBO Rep; 2008 May; 9(5):486-91. PubMed ID: 18323857
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Role of exon 2-encoded beta -domain of the von Hippel-Lindau tumor suppressor protein.
    Bonicalzi ME; Groulx I; de Paulsen N ; Lee S
    J Biol Chem; 2001 Jan; 276(2):1407-16. PubMed ID: 11024059
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Role of the NEDD8 modification of Cul2 in the sequential activation of ECV complex.
    Sufan RI; Ohh M
    Neoplasia; 2006 Nov; 8(11):956-63. PubMed ID: 17132228
    [TBL] [Abstract][Full Text] [Related]  

  • 4. DCNL1 functions as a substrate sensor and activator of cullin 2-RING ligase.
    Heir P; Sufan RI; Greer SN; Poon BP; Lee JE; Ohh M
    Mol Cell Biol; 2013 Apr; 33(8):1621-31. PubMed ID: 23401859
    [TBL] [Abstract][Full Text] [Related]  

  • 5. pVHL modification by NEDD8 is required for fibronectin matrix assembly and suppression of tumor development.
    Stickle NH; Chung J; Klco JM; Hill RP; Kaelin WG; Ohh M
    Mol Cell Biol; 2004 Apr; 24(8):3251-61. PubMed ID: 15060148
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Diverse effects of mutations in exon II of the von Hippel-Lindau (VHL) tumor suppressor gene on the interaction of pVHL with the cytosolic chaperonin and pVHL-dependent ubiquitin ligase activity.
    Hansen WJ; Ohh M; Moslehi J; Kondo K; Kaelin WG; Welch WJ
    Mol Cell Biol; 2002 Mar; 22(6):1947-60. PubMed ID: 11865071
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Identification of Elongin C and Skp1 sequences that determine Cullin selection.
    Yan Q; Kamura T; Cai Y; Jin J; Ivan M; Mushegian A; Conaway RC; Conaway JW
    J Biol Chem; 2004 Oct; 279(41):43019-26. PubMed ID: 15280393
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The von Hippel-Lindau tumor suppressor gene product promotes, but is not essential for, NEDD8 conjugation to cullin-2.
    Wada H; Yeh ET; Kamitani T
    J Biol Chem; 1999 Dec; 274(50):36025-9. PubMed ID: 10585493
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Role of SOCS and VHL Proteins in Neuronal Differentiation and Development.
    Kanno H; Matsumoto S; Yoshizumi T; Nakahara K; Kubo A; Murata H; Shuin T; U HS
    Int J Mol Sci; 2023 Feb; 24(4):. PubMed ID: 36835292
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Regulation of DNA topoisomerase IIalpha stability by the ECV ubiquitin ligase complex.
    Yun J; Kim YI; Tomida A; Choi CH
    Biochem Biophys Res Commun; 2009 Nov; 389(1):5-9. PubMed ID: 19695223
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Conjugation of the ubiquitin-like protein NEDD8 to cullin-2 is linked to von Hippel-Lindau tumor suppressor function.
    Liakopoulos D; Büsgen T; Brychzy A; Jentsch S; Pause A
    Proc Natl Acad Sci U S A; 1999 May; 96(10):5510-5. PubMed ID: 10318914
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The pVHL-associated SCF ubiquitin ligase complex: molecular genetic analysis of elongin B and C, Rbx1 and HIF-1alpha in renal cell carcinoma.
    Clifford SC; Astuti D; Hooper L; Maxwell PH; Ratcliffe PJ; Maher ER
    Oncogene; 2001 Aug; 20(36):5067-74. PubMed ID: 11526493
    [TBL] [Abstract][Full Text] [Related]  

  • 13. von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF.
    Hoffman MA; Ohh M; Yang H; Klco JM; Ivan M; Kaelin WG
    Hum Mol Genet; 2001 May; 10(10):1019-27. PubMed ID: 11331612
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.
    Clifford SC; Cockman ME; Smallwood AC; Mole DR; Woodward ER; Maxwell PH; Ratcliffe PJ; Maher ER
    Hum Mol Genet; 2001 May; 10(10):1029-38. PubMed ID: 11331613
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Crystal Structure of the Cul2-Rbx1-EloBC-VHL Ubiquitin Ligase Complex.
    Cardote TAF; Gadd MS; Ciulli A
    Structure; 2017 Jun; 25(6):901-911.e3. PubMed ID: 28591624
    [TBL] [Abstract][Full Text] [Related]  

  • 16. EC5S ubiquitin complex is recruited by KSHV latent antigen LANA for degradation of the VHL and p53 tumor suppressors.
    Cai QL; Knight JS; Verma SC; Zald P; Robertson ES
    PLoS Pathog; 2006 Oct; 2(10):e116. PubMed ID: 17069461
    [TBL] [Abstract][Full Text] [Related]  

  • 17. CUL2-mediated clearance of misfolded TDP-43 is paradoxically affected by VHL in oligodendrocytes in ALS.
    Uchida T; Tamaki Y; Ayaki T; Shodai A; Kaji S; Morimura T; Banno Y; Nishitsuji K; Sakashita N; Maki T; Yamashita H; Ito H; Takahashi R; Urushitani M
    Sci Rep; 2016 Jan; 6():19118. PubMed ID: 26751167
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The COP9/signalosome increases the efficiency of von Hippel-Lindau protein ubiquitin ligase-mediated hypoxia-inducible factor-alpha ubiquitination.
    Miyauchi Y; Kato M; Tokunaga F; Iwai K
    J Biol Chem; 2008 Jun; 283(24):16622-31. PubMed ID: 18424433
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Expression of fibronectin and HIF-1alpha in renal cell carcinomas: relationship to von Hippel-Lindau gene inactivation.
    He Z; Liu S; Guo M; Mao J; Hughson MD
    Cancer Genet Cytogenet; 2004 Jul; 152(2):89-94. PubMed ID: 15262424
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Proteomic dissection of the von Hippel-Lindau (VHL) interactome.
    Lai Y; Song M; Hakala K; Weintraub ST; Shiio Y
    J Proteome Res; 2011 Nov; 10(11):5175-82. PubMed ID: 21942715
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.