740 related articles for article (PubMed ID: 18337408)
21. PRMT5- mediated symmetric arginine dimethylation is attenuated by mutant huntingtin and is impaired in Huntington's disease (HD).
Ratovitski T; Arbez N; Stewart JC; Chighladze E; Ross CA
Cell Cycle; 2015; 14(11):1716-29. PubMed ID: 25927346
[TBL] [Abstract][Full Text] [Related]
22. Preventing formation of toxic N-terminal huntingtin fragments through antisense oligonucleotide-mediated protein modification.
Evers MM; Tran HD; Zalachoras I; Meijer OC; den Dunnen JT; van Ommen GJ; Aartsma-Rus A; van Roon-Mom WM
Nucleic Acid Ther; 2014 Feb; 24(1):4-12. PubMed ID: 24380395
[TBL] [Abstract][Full Text] [Related]
23. Mutant huntingtin in glial cells exacerbates neurological symptoms of Huntington disease mice.
Bradford J; Shin JY; Roberts M; Wang CE; Sheng G; Li S; Li XJ
J Biol Chem; 2010 Apr; 285(14):10653-61. PubMed ID: 20145253
[TBL] [Abstract][Full Text] [Related]
24. Inhibition of mitochondrial protein import by mutant huntingtin.
Yano H; Baranov SV; Baranova OV; Kim J; Pan Y; Yablonska S; Carlisle DL; Ferrante RJ; Kim AH; Friedlander RM
Nat Neurosci; 2014 Jun; 17(6):822-31. PubMed ID: 24836077
[TBL] [Abstract][Full Text] [Related]
25. N-terminal Huntingtin Knock-In Mice: Implications of Removing the N-terminal Region of Huntingtin for Therapy.
Liu X; Wang CE; Hong Y; Zhao T; Wang G; Gaertig MA; Sun M; Li S; Li XJ
PLoS Genet; 2016 May; 12(5):e1006083. PubMed ID: 27203582
[TBL] [Abstract][Full Text] [Related]
26. Mutant huntingtin, abnormal mitochondrial dynamics, defective axonal transport of mitochondria, and selective synaptic degeneration in Huntington's disease.
Reddy PH; Shirendeb UP
Biochim Biophys Acta; 2012 Feb; 1822(2):101-10. PubMed ID: 22080977
[TBL] [Abstract][Full Text] [Related]
27. Tumor necrosis factor receptor-associated factor 6 (TRAF6) associates with huntingtin protein and promotes its atypical ubiquitination to enhance aggregate formation.
Zucchelli S; Marcuzzi F; Codrich M; Agostoni E; Vilotti S; Biagioli M; Pinto M; Carnemolla A; Santoro C; Gustincich S; Persichetti F
J Biol Chem; 2011 Jul; 286(28):25108-17. PubMed ID: 21454471
[TBL] [Abstract][Full Text] [Related]
28. Clearance of mutant huntingtin.
Li XJ; Li H; Li S
Autophagy; 2010 Jul; 6(5):663-4. PubMed ID: 20519964
[TBL] [Abstract][Full Text] [Related]
29. Progressive phenotype and nuclear accumulation of an amino-terminal cleavage fragment in a transgenic mouse model with inducible expression of full-length mutant huntingtin.
Tanaka Y; Igarashi S; Nakamura M; Gafni J; Torcassi C; Schilling G; Crippen D; Wood JD; Sawa A; Jenkins NA; Copeland NG; Borchelt DR; Ross CA; Ellerby LM
Neurobiol Dis; 2006 Feb; 21(2):381-91. PubMed ID: 16150600
[TBL] [Abstract][Full Text] [Related]
30. Dopamine D1 receptor-mediated aggregation of N-terminal fragments of mutant huntingtin and cell death in a neuroblastoma cell line.
Robinson P; Lebel M; Cyr M
Neuroscience; 2008 May; 153(3):762-72. PubMed ID: 18403126
[TBL] [Abstract][Full Text] [Related]
31. Mechanisms for neuronal cell death and dysfunction in Huntington's disease: pathological cross-talk between the nucleus and the mitochondria?
Sawa A
J Mol Med (Berl); 2001 Jul; 79(7):375-81. PubMed ID: 11466559
[TBL] [Abstract][Full Text] [Related]
32. Native mutant huntingtin in human brain: evidence for prevalence of full-length monomer.
Sapp E; Valencia A; Li X; Aronin N; Kegel KB; Vonsattel JP; Young AB; Wexler N; DiFiglia M
J Biol Chem; 2012 Apr; 287(16):13487-99. PubMed ID: 22375012
[TBL] [Abstract][Full Text] [Related]
33. Mutant huntingtin promotes the fibrillogenesis of wild-type huntingtin: a potential mechanism for loss of huntingtin function in Huntington's disease.
Busch A; Engemann S; Lurz R; Okazawa H; Lehrach H; Wanker EE
J Biol Chem; 2003 Oct; 278(42):41452-61. PubMed ID: 12888569
[TBL] [Abstract][Full Text] [Related]
34. Transgenic mice expressing caspase-6-derived N-terminal fragments of mutant huntingtin develop neurologic abnormalities with predominant cytoplasmic inclusion pathology composed largely of a smaller proteolytic derivative.
Tebbenkamp AT; Green C; Xu G; Denovan-Wright EM; Rising AC; Fromholt SE; Brown HH; Swing D; Mandel RJ; Tessarollo L; Borchelt DR
Hum Mol Genet; 2011 Jul; 20(14):2770-82. PubMed ID: 21515588
[TBL] [Abstract][Full Text] [Related]
35. Nuclear-targeting of mutant huntingtin fragments produces Huntington's disease-like phenotypes in transgenic mice.
Schilling G; Savonenko AV; Klevytska A; Morton JL; Tucker SM; Poirier M; Gale A; Chan N; Gonzales V; Slunt HH; Coonfield ML; Jenkins NA; Copeland NG; Ross CA; Borchelt DR
Hum Mol Genet; 2004 Aug; 13(15):1599-610. PubMed ID: 15190011
[TBL] [Abstract][Full Text] [Related]
36. Aggregation in Huntington's disease: insights through modelling.
Cajavec B; Bernard S; Herzel H
Genome Inform; 2005; 16(1):262-71. PubMed ID: 16362929
[TBL] [Abstract][Full Text] [Related]
37. A role of mitochondrial complex II defects in genetic models of Huntington's disease expressing N-terminal fragments of mutant huntingtin.
Damiano M; Diguet E; Malgorn C; D'Aurelio M; Galvan L; Petit F; Benhaim L; Guillermier M; Houitte D; Dufour N; Hantraye P; Canals JM; Alberch J; Delzescaux T; Déglon N; Beal MF; Brouillet E
Hum Mol Genet; 2013 Oct; 22(19):3869-82. PubMed ID: 23720495
[TBL] [Abstract][Full Text] [Related]
38. Adenovirus vector-based in vitro neuronal cell model for Huntington's disease with human disease-like differential aggregation and degeneration.
Dong X; Zong S; Witting A; Lindenberg KS; Kochanek S; Huang B
J Gene Med; 2012 Jul; 14(7):468-81. PubMed ID: 22700462
[TBL] [Abstract][Full Text] [Related]
39. Mutant huntingtin fragments form oligomers in a polyglutamine length-dependent manner in vitro and in vivo.
Legleiter J; Mitchell E; Lotz GP; Sapp E; Ng C; DiFiglia M; Thompson LM; Muchowski PJ
J Biol Chem; 2010 May; 285(19):14777-90. PubMed ID: 20220138
[TBL] [Abstract][Full Text] [Related]
40. Genetic background modifies nuclear mutant huntingtin accumulation and HD CAG repeat instability in Huntington's disease knock-in mice.
Lloret A; Dragileva E; Teed A; Espinola J; Fossale E; Gillis T; Lopez E; Myers RH; MacDonald ME; Wheeler VC
Hum Mol Genet; 2006 Jun; 15(12):2015-24. PubMed ID: 16687439
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]
