BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

741 related articles for article (PubMed ID: 18337408)

  • 41. Multiple phenotypes in Huntington disease mouse neural stem cells.
    Ritch JJ; Valencia A; Alexander J; Sapp E; Gatune L; Sangrey GR; Sinha S; Scherber CM; Zeitlin S; Sadri-Vakili G; Irimia D; Difiglia M; Kegel KB
    Mol Cell Neurosci; 2012 May; 50(1):70-81. PubMed ID: 22508027
    [TBL] [Abstract][Full Text] [Related]  

  • 42. Selective degeneration in YAC mouse models of Huntington disease.
    Van Raamsdonk JM; Warby SC; Hayden MR
    Brain Res Bull; 2007 Apr; 72(2-3):124-31. PubMed ID: 17352936
    [TBL] [Abstract][Full Text] [Related]  

  • 43. Lack of huntingtin promotes neural stem cells differentiation into glial cells while neurons expressing huntingtin with expanded polyglutamine tracts undergo cell death.
    Conforti P; Camnasio S; Mutti C; Valenza M; Thompson M; Fossale E; Zeitlin S; MacDonald ME; Zuccato C; Cattaneo E
    Neurobiol Dis; 2013 Feb; 50():160-70. PubMed ID: 23089356
    [TBL] [Abstract][Full Text] [Related]  

  • 44. Elucidating a normal function of huntingtin by functional and microarray analysis of huntingtin-null mouse embryonic fibroblasts.
    Zhang H; Das S; Li QZ; Dragatsis I; Repa J; Zeitlin S; Hajnóczky G; Bezprozvanny I
    BMC Neurosci; 2008 Apr; 9():38. PubMed ID: 18412970
    [TBL] [Abstract][Full Text] [Related]  

  • 45. Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease.
    Hermel E; Gafni J; Propp SS; Leavitt BR; Wellington CL; Young JE; Hackam AS; Logvinova AV; Peel AL; Chen SF; Hook V; Singaraja R; Krajewski S; Goldsmith PC; Ellerby HM; Hayden MR; Bredesen DE; Ellerby LM
    Cell Death Differ; 2004 Apr; 11(4):424-38. PubMed ID: 14713958
    [TBL] [Abstract][Full Text] [Related]  

  • 46. Wild type Huntingtin reduces the cellular toxicity of mutant Huntingtin in mammalian cell models of Huntington's disease.
    Ho LW; Brown R; Maxwell M; Wyttenbach A; Rubinsztein DC
    J Med Genet; 2001 Jul; 38(7):450-2. PubMed ID: 11432963
    [TBL] [Abstract][Full Text] [Related]  

  • 47. A human single-chain Fv intrabody preferentially targets amino-terminal Huntingtin's fragments in striatal models of Huntington's disease.
    Miller TW; Zhou C; Gines S; MacDonald ME; Mazarakis ND; Bates GP; Huston JS; Messer A
    Neurobiol Dis; 2005; 19(1-2):47-56. PubMed ID: 15837560
    [TBL] [Abstract][Full Text] [Related]  

  • 48. Bcl-2/adenovirus E1B 19-kDa interacting protein (BNip3) has a key role in the mitochondrial dysfunction induced by mutant huntingtin.
    Sassone F; Margulets V; Maraschi A; Rodighiero S; Passafaro M; Silani V; Ciammola A; Kirshenbaum LA; Sassone J
    Hum Mol Genet; 2015 Nov; 24(22):6530-9. PubMed ID: 26358776
    [TBL] [Abstract][Full Text] [Related]  

  • 49. A structure-based analysis of huntingtin mutant polyglutamine aggregation and toxicity: evidence for a compact beta-sheet structure.
    Poirier MA; Jiang H; Ross CA
    Hum Mol Genet; 2005 Mar; 14(6):765-74. PubMed ID: 15689354
    [TBL] [Abstract][Full Text] [Related]  

  • 50. Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin.
    Graham RK; Deng Y; Slow EJ; Haigh B; Bissada N; Lu G; Pearson J; Shehadeh J; Bertram L; Murphy Z; Warby SC; Doty CN; Roy S; Wellington CL; Leavitt BR; Raymond LA; Nicholson DW; Hayden MR
    Cell; 2006 Jun; 125(6):1179-91. PubMed ID: 16777606
    [TBL] [Abstract][Full Text] [Related]  

  • 51. Modulation of mutant Huntingtin aggregates and toxicity by human myeloid leukemia factors.
    Banerjee M; Datta M; Bhattacharyya NP
    Int J Biochem Cell Biol; 2017 Jan; 82():1-9. PubMed ID: 27840155
    [TBL] [Abstract][Full Text] [Related]  

  • 52. Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus.
    Gafni J; Hermel E; Young JE; Wellington CL; Hayden MR; Ellerby LM
    J Biol Chem; 2004 May; 279(19):20211-20. PubMed ID: 14981075
    [TBL] [Abstract][Full Text] [Related]  

  • 53. Mutant Huntingtin Protein Interaction Map Implicates Dysregulation of Multiple Cellular Pathways in Neurodegeneration of Huntington's Disease.
    Podvin S; Rosenthal SB; Poon W; Wei E; Fisch KM; Hook V
    J Huntingtons Dis; 2022; 11(3):243-267. PubMed ID: 35871359
    [TBL] [Abstract][Full Text] [Related]  

  • 54. Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release.
    Jana NR; Zemskov EA; Wang Gh ; Nukina N
    Hum Mol Genet; 2001 May; 10(10):1049-59. PubMed ID: 11331615
    [TBL] [Abstract][Full Text] [Related]  

  • 55. A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.
    Hodgson JG; Agopyan N; Gutekunst CA; Leavitt BR; LePiane F; Singaraja R; Smith DJ; Bissada N; McCutcheon K; Nasir J; Jamot L; Li XJ; Stevens ME; Rosemond E; Roder JC; Phillips AG; Rubin EM; Hersch SM; Hayden MR
    Neuron; 1999 May; 23(1):181-92. PubMed ID: 10402204
    [TBL] [Abstract][Full Text] [Related]  

  • 56. Inducing huntingtin inclusion formation in primary neuronal cell culture and in vivo by high-capacity adenoviral vectors expressing truncated and full-length huntingtin with polyglutamine expansion.
    Huang B; Schiefer J; Sass C; Kosinski CM; Kochanek S
    J Gene Med; 2008 Mar; 10(3):269-79. PubMed ID: 18067195
    [TBL] [Abstract][Full Text] [Related]  

  • 57. Essential sequence of the N-terminal cytoplasmic localization-related domain of huntingtin and its effect on huntingtin aggregates.
    Yan Y; Peng D; Tian J; Chi J; Tan J; Yin X; Pu J; Xia K; Zhang B
    Sci China Life Sci; 2011 Apr; 54(4):342-50. PubMed ID: 21509658
    [TBL] [Abstract][Full Text] [Related]  

  • 58. The dynamics of early-state transcriptional changes and aggregate formation in a Huntington's disease cell model.
    van Hagen M; Piebes DGE; de Leeuw WC; Vuist IM; van Roon-Mom WMC; Moerland PD; Verschure PJ
    BMC Genomics; 2017 May; 18(1):373. PubMed ID: 28499347
    [TBL] [Abstract][Full Text] [Related]  

  • 59. In vitro evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in Huntington's disease.
    Hackam AS; Singaraja R; Zhang T; Gan L; Hayden MR
    Hum Mol Genet; 1999 Jan; 8(1):25-33. PubMed ID: 9887328
    [TBL] [Abstract][Full Text] [Related]  

  • 60. Autophagy regulates the processing of amino terminal huntingtin fragments.
    Qin ZH; Wang Y; Kegel KB; Kazantsev A; Apostol BL; Thompson LM; Yoder J; Aronin N; DiFiglia M
    Hum Mol Genet; 2003 Dec; 12(24):3231-44. PubMed ID: 14570716
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 38.