These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

395 related articles for article (PubMed ID: 18338894)

  • 21. Discovery of the HCV NS3/4A protease inhibitor (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key steps in structure-based optimization.
    Prongay AJ; Guo Z; Yao N; Pichardo J; Fischmann T; Strickland C; Myers J; Weber PC; Beyer BM; Ingram R; Hong Z; Prosise WW; Ramanathan L; Taremi SS; Yarosh-Tomaine T; Zhang R; Senior M; Yang RS; Malcolm B; Arasappan A; Bennett F; Bogen SL; Chen K; Jao E; Liu YT; Lovey RG; Saksena AK; Venkatraman S; Girijavallabhan V; Njoroge FG; Madison V
    J Med Chem; 2007 May; 50(10):2310-8. PubMed ID: 17444623
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Development of potent macrocyclic inhibitors of genotype 3a HCV NS3/4A protease.
    Rudd MT; McCauley JA; Romano JJ; Butcher JW; Bush K; McIntyre CJ; Nguyen KT; Gilbert KF; Lyle TA; Holloway MK; Wan BL; Vacca JP; Summa V; Harper S; Rowley M; Carroll SS; Burlein C; DiMuzio JM; Gates A; Graham DJ; Huang Q; Ludmerer SW; McClain S; McHale C; Stahlhut M; Fandozzi C; Taylor A; Trainor N; Olsen DB; Liverton NJ
    Bioorg Med Chem Lett; 2012 Dec; 22(23):7201-6. PubMed ID: 23021993
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Design, synthesis, and evaluation of oxygen-containing macrocyclic peptidomimetics as inhibitors of HCV NS3 protease.
    Velázquez F; Venkatraman S; Blackman M; Pinto P; Bogen S; Sannigrahi M; Chen K; Pichardo J; Hart A; Tong X; Girijavallabhan V; Njoroge FG
    J Med Chem; 2009 Feb; 52(3):700-8. PubMed ID: 19154150
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Development of macrocyclic inhibitors of HCV NS3/4A protease with cyclic constrained P2-P4 linkers.
    Rudd MT; McIntyre CJ; Romano JJ; Butcher JW; Holloway MK; Bush K; Nguyen KT; Gilbert KF; Lyle TA; Liverton NJ; Wan BL; Summa V; Harper S; Rowley M; Vacca JP; Carroll SS; Burlein C; DiMuzio JM; Gates A; Graham DJ; Huang Q; Ludmerer SW; McClain S; McHale C; Stahlhut M; Fandozzi C; Taylor A; Trainor N; Olsen DB; McCauley JA
    Bioorg Med Chem Lett; 2012 Dec; 22(23):7207-13. PubMed ID: 23084906
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Bismacrocyclic inhibitors of hepatitis C NS3/4a protease.
    McCauley JA; Rudd MT; Nguyen KT; McIntyre CJ; Romano JJ; Bush KJ; Varga SL; Ross CW; Carroll SS; DiMuzio J; Stahlhut MW; Olsen DB; Lyle TA; Vacca JP; Liverton NJ
    Angew Chem Int Ed Engl; 2008; 47(47):9104-7. PubMed ID: 18925594
    [No Abstract]   [Full Text] [Related]  

  • 26. Depeptidization efforts on P3-P2' alpha-ketoamide inhibitors of HCV NS3-4A serine protease: effect on HCV replicon activity.
    Bogen SL; Ruan S; Liu R; Agrawal S; Pichardo J; Prongay A; Baroudy B; Saksena AK; Girijavallabhan V; Njoroge FG
    Bioorg Med Chem Lett; 2006 Mar; 16(6):1621-7. PubMed ID: 16387495
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Discovery of vaniprevir (MK-7009), a macrocyclic hepatitis C virus NS3/4a protease inhibitor.
    McCauley JA; McIntyre CJ; Rudd MT; Nguyen KT; Romano JJ; Butcher JW; Gilbert KF; Bush KJ; Holloway MK; Swestock J; Wan BL; Carroll SS; DiMuzio JM; Graham DJ; Ludmerer SW; Mao SS; Stahlhut MW; Fandozzi CM; Trainor N; Olsen DB; Vacca JP; Liverton NJ
    J Med Chem; 2010 Mar; 53(6):2443-63. PubMed ID: 20163176
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Computer based design, synthesis and biological evaluation of novel indole derivatives as HCV NS3-4A serine protease inhibitors.
    Ismail NS; El Dine RS; Hattori M; Takahashi K; Ihara M
    Bioorg Med Chem; 2008 Sep; 16(17):7877-87. PubMed ID: 18752958
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Novel 2-oxoimidazolidine-4-carboxylic acid derivatives as hepatitis C virus NS3-4A serine protease inhibitors: synthesis, activity, and X-ray crystal structure of an enzyme inhibitor complex.
    Arasappan A; Njoroge FG; Parekh TN; Yang X; Pichardo J; Butkiewicz N; Prongay A; Yao N; Girijavallabhan V
    Bioorg Med Chem Lett; 2004 Dec; 14(23):5751-5. PubMed ID: 15501035
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Potent and selective small molecule NS3 serine protease inhibitors of Hepatitis C virus with dichlorocyclopropylproline as P2 residue.
    Chen KX; Vibulbhan B; Yang W; Cheng KC; Liu R; Pichardo J; Butkiewicz N; Njoroge FG
    Bioorg Med Chem; 2008 Feb; 16(4):1874-83. PubMed ID: 18032054
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Synthesis of new acylsulfamoyl benzoxaboroles as potent inhibitors of HCV NS3 protease.
    Li X; Zhang YK; Liu Y; Zhang S; Ding CZ; Zhou Y; Plattner JJ; Baker SJ; Liu L; Bu W; Kazmierski WM; Wright LL; Smith GK; Jarvest RL; Duan M; Ji JJ; Cooper JP; Tallant MD; Crosby RM; Creech K; Ni ZJ; Zou W; Wright J
    Bioorg Med Chem Lett; 2010 Dec; 20(24):7493-7. PubMed ID: 21041080
    [TBL] [Abstract][Full Text] [Related]  

  • 32. SAR and pharmacokinetic studies on phenethylamide inhibitors of the hepatitis C virus NS3/NS4A serine protease.
    Malancona S; Colarusso S; Ontoria JM; Marchetti A; Poma M; Stansfield I; Laufer R; Di Marco A; Taliani M; Verdirame M; Gonzalez-Paz O; Matassa VG; Narjes F
    Bioorg Med Chem Lett; 2004 Sep; 14(17):4575-9. PubMed ID: 15357995
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Blunting the Swiss army knife of hepatitis C virus: inhibitors of NS3/4A protease.
    White PW; Llinas-Brunet M; Bös M
    Prog Med Chem; 2006; 44():65-107. PubMed ID: 16697895
    [No Abstract]   [Full Text] [Related]  

  • 34. Cyclic sulfones as novel P3-caps for hepatitis C virus NS3/4A (HCV NS3/4A) protease inhibitors: synthesis and evaluation of inhibitors with improved potency and pharmacokinetic profiles.
    Velázquez F; Sannigrahi M; Bennett F; Lovey RG; Arasappan A; Bogen S; Nair L; Venkatraman S; Blackman M; Hendrata S; Huang Y; Huelgas R; Pinto P; Cheng KC; Tong X; McPhail AT; Njoroge FG
    J Med Chem; 2010 Apr; 53(8):3075-85. PubMed ID: 20302300
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Discovery of potent sulfonamide P4-capped ketoamide second generation inhibitors of hepatitis C virus NS3 serine protease with favorable pharmacokinetic profiles in preclinical species.
    Bogen SL; Arasappan A; Velazquez F; Blackman M; Huelgas R; Pan W; Siegel E; Nair LG; Venkatraman S; Guo Z; Doll R; Shih NY; Njoroge FG
    Bioorg Med Chem; 2010 Mar; 18(5):1854-65. PubMed ID: 20149666
    [TBL] [Abstract][Full Text] [Related]  

  • 36. An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus.
    Lamarre D; Anderson PC; Bailey M; Beaulieu P; Bolger G; Bonneau P; Bös M; Cameron DR; Cartier M; Cordingley MG; Faucher AM; Goudreau N; Kawai SH; Kukolj G; Lagacé L; LaPlante SR; Narjes H; Poupart MA; Rancourt J; Sentjens RE; St George R; Simoneau B; Steinmann G; Thibeault D; Tsantrizos YS; Weldon SM; Yong CL; Llinàs-Brunet M
    Nature; 2003 Nov; 426(6963):186-9. PubMed ID: 14578911
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Potent aza-peptide derived inhibitors of HCV NS3 protease.
    Venkatraman S; Wu W; Shih NY; George Njoroge F
    Bioorg Med Chem Lett; 2009 Aug; 19(16):4760-3. PubMed ID: 19596195
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Macrocyclic inhibitors of HCV NS3 protease.
    Venkatraman S; Njoroge FG
    Expert Opin Ther Pat; 2009 Sep; 19(9):1277-303. PubMed ID: 19563268
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Synthesis and antiviral evaluation of a novel series of homoserine-based inhibitors of the hepatitis C virus NS3/4A serine protease.
    Alexandre FR; Brandt G; Caillet C; Chaves D; Convard T; Derock M; Gloux D; Griffon Y; Lallos L; Leroy F; Liuzzi M; Loi AG; Moulat L; Musiu C; Parsy C; Rahali H; Roques V; Seifer M; Standring D; Surleraux D
    Bioorg Med Chem Lett; 2015 Sep; 25(18):3984-91. PubMed ID: 26231161
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Proline-based macrocyclic inhibitors of the hepatitis C virus: stereoselective synthesis and biological activity.
    Chen KX; Njoroge FG; Vibulbhan B; Prongay A; Pichardo J; Madison V; Buevich A; Chan TM
    Angew Chem Int Ed Engl; 2005 Nov; 44(43):7024-8. PubMed ID: 16211639
    [No Abstract]   [Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 20.