BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

321 related articles for article (PubMed ID: 18346892)

  • 1. Structure-based design and synthesis of benzimidazole derivatives as dipeptidyl peptidase IV inhibitors.
    Wallace MB; Feng J; Zhang Z; Skene RJ; Shi L; Caster CL; Kassel DB; Xu R; Gwaltney SL
    Bioorg Med Chem Lett; 2008 Apr; 18(7):2362-7. PubMed ID: 18346892
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovery of beta-homophenylalanine based pyrrolidin-2-ylmethyl amides and sulfonamides as highly potent and selective inhibitors of dipeptidyl peptidase IV.
    Nordhoff S; Cerezo-Gálvez S; Deppe H; Hill O; López-Canet M; Rummey C; Thiemann M; Matassa VG; Edwards PJ; Feurer A
    Bioorg Med Chem Lett; 2009 Aug; 19(15):4201-3. PubMed ID: 19515557
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Novel N-substituted 4-hydrazino piperidine derivative as a dipeptidyl peptidase IV inhibitor.
    Gupta RC; Chhipa L; Mandhare AB; Zambad SP; Chauthaiwale V; Nadkarni SS; Dutt C
    Bioorg Med Chem Lett; 2009 Sep; 19(17):5021-5. PubMed ID: 19643608
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Rational design and synthesis of potent and long-lasting glutamic acid-based dipeptidyl peptidase IV inhibitors.
    Tsai TY; Hsu T; Chen CT; Cheng JH; Chiou MC; Huang CH; Tseng YJ; Yeh TK; Huang CY; Yeh KC; Huang YW; Wu SH; Wang MH; Chen X; Chao YS; Jiaang WT
    Bioorg Med Chem Lett; 2009 Apr; 19(7):1908-12. PubMed ID: 19269819
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Aminopiperidine-fused imidazoles as dipeptidyl peptidase-IV inhibitors.
    Edmondson SD; Mastracchio A; Cox JM; Eiermann GJ; He H; Lyons KA; Patel RA; Patel SB; Petrov A; Scapin G; Wu JK; Xu S; Zhu B; Thornberry NA; Roy RS; Weber AE
    Bioorg Med Chem Lett; 2009 Aug; 19(15):4097-101. PubMed ID: 19539471
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Discovery of carmegliptin: a potent and long-acting dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
    Mattei P; Boehringer M; Di Giorgio P; Fischer H; Hennig M; Huwyler J; Koçer B; Kuhn B; Loeffler BM; Macdonald A; Narquizian R; Rauber E; Sebokova E; Sprecher U
    Bioorg Med Chem Lett; 2010 Feb; 20(3):1109-13. PubMed ID: 20031405
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Identification of 3-aminomethyl-1,2-dihydro-4-phenyl-1-isoquinolones: a new class of potent, selective, and orally active non-peptide dipeptidyl peptidase IV inhibitors that form a unique interaction with Lys554.
    Banno Y; Miyamoto Y; Sasaki M; Oi S; Asakawa T; Kataoka O; Takeuchi K; Suzuki N; Ikedo K; Kosaka T; Tsubotani S; Tani A; Funami M; Tawada M; Yamamoto Y; Aertgeerts K; Yano J; Maezaki H
    Bioorg Med Chem; 2011 Aug; 19(16):4953-70. PubMed ID: 21764322
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structure-based design of pyridopyrimidinediones as dipeptidyl peptidase IV inhibitors.
    Lam B; Zhang Z; Stafford JA; Skene RJ; Shi L; Gwaltney SL
    Bioorg Med Chem Lett; 2012 Nov; 22(21):6628-31. PubMed ID: 23025999
    [TBL] [Abstract][Full Text] [Related]  

  • 9. (3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone: a potent, selective, orally active dipeptidyl peptidase IV inhibitor.
    Ammirati MJ; Andrews KM; Boyer DD; Brodeur AM; Danley DE; Doran SD; Hulin B; Liu S; McPherson RK; Orena SJ; Parker JC; Polivkova J; Qiu X; Soglia CB; Treadway JL; VanVolkenburg MA; Wilder DC; Piotrowski DW
    Bioorg Med Chem Lett; 2009 Apr; 19(7):1991-5. PubMed ID: 19275964
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Design and synthesis of pyrimidinone and pyrimidinedione inhibitors of dipeptidyl peptidase IV.
    Zhang Z; Wallace MB; Feng J; Stafford JA; Skene RJ; Shi L; Lee B; Aertgeerts K; Jennings A; Xu R; Kassel DB; Kaldor SW; Navre M; Webb DR; Gwaltney SL
    J Med Chem; 2011 Jan; 54(2):510-24. PubMed ID: 21186796
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Discovery, SAR, and X-ray structure of novel biaryl-based dipeptidyl peptidase IV inhibitors.
    Qiao L; Baumann CA; Crysler CS; Ninan NS; Abad MC; Spurlino JC; Desjarlais RL; Kervinen J; Neeper MP; Bayoumy SS; Williams R; Deckman IC; Dasgupta M; Reed RL; Huebert ND; Tomczuk BE; Moriarty KJ
    Bioorg Med Chem Lett; 2006 Jan; 16(1):123-8. PubMed ID: 16236500
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Discovery of novel 2-(pyridine-2-yl)-1H-benzimidazole derivatives as potent glucokinase activators.
    Ishikawa M; Nonoshita K; Ogino Y; Nagae Y; Tsukahara D; Hosaka H; Maruki H; Ohyama S; Yoshimoto R; Sasaki K; Nagata Y; Eiki J; Nishimura T
    Bioorg Med Chem Lett; 2009 Aug; 19(15):4450-4. PubMed ID: 19540111
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis and evaluation of structurally constrained imidazolidin derivatives as potent dipeptidyl peptidase IV inhibitors.
    Wang L; Zhang B; Ji J; Li B; Yan J; Zhang W; Wu Y; Wang X
    Eur J Med Chem; 2009 Aug; 44(8):3318-22. PubMed ID: 19375196
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors.
    Edmondson SD; Wei L; Xu J; Shang J; Xu S; Pang J; Chaudhary A; Dean DC; He H; Leiting B; Lyons KA; Patel RA; Patel SB; Scapin G; Wu JK; Beconi MG; Thornberry NA; Weber AE
    Bioorg Med Chem Lett; 2008 Apr; 18(7):2409-13. PubMed ID: 18331795
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Design and synthesis of 3-pyridylacetamide derivatives as dipeptidyl peptidase IV (DPP-4) inhibitors targeting a bidentate interaction with Arg125.
    Miyamoto Y; Banno Y; Yamashita T; Fujimoto T; Oi S; Moritoh Y; Asakawa T; Kataoka O; Takeuchi K; Suzuki N; Ikedo K; Kosaka T; Tsubotani S; Tani A; Funami M; Amano M; Yamamoto Y; Aertgeerts K; Yano J; Maezaki H
    Bioorg Med Chem; 2011 Jan; 19(1):172-85. PubMed ID: 21163664
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Discovery of β-aminoacyl containing thiazolidine derivatives as potent and selective dipeptidyl peptidase IV inhibitors.
    Park WS; Kang SK; Jun MA; Shin MS; Kim KY; Rhee SD; Bae MA; Kim MS; Kim KR; Kang NS; Yoo SE; Lee JO; Song DH; Silinski P; Schneider SE; Ahn JH; Kim SS
    Bioorg Med Chem Lett; 2011 Mar; 21(5):1366-70. PubMed ID: 21306895
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Piperidinyl-2-phenethylamino inhibitors of DPP-IV for the treatment of type 2 diabetes.
    Benbow JW; Andrews KA; Aubrecht J; Beebe D; Boyer D; Doran S; Homiski M; Hui Y; McPherson K; Parker JC; Treadway J; Vanvolkenberg M; Zembrowski WJ
    Bioorg Med Chem Lett; 2009 Apr; 19(8):2220-3. PubMed ID: 19285862
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Discovery of a 3-pyridylacetic acid derivative (TAK-100) as a potent, selective and orally active dipeptidyl peptidase IV (DPP-4) inhibitor.
    Miyamoto Y; Banno Y; Yamashita T; Fujimoto T; Oi S; Moritoh Y; Asakawa T; Kataoka O; Yashiro H; Takeuchi K; Suzuki N; Ikedo K; Kosaka T; Tsubotani S; Tani A; Sasaki M; Funami M; Amano M; Yamamoto Y; Aertgeerts K; Yano J; Maezaki H
    J Med Chem; 2011 Feb; 54(3):831-50. PubMed ID: 21218817
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The design of potent and selective inhibitors of DPP-4: optimization of ADME properties by amide replacements.
    Nordhoff S; Bulat S; Cerezo-Gálvez S; Hill O; Hoffmann-Enger B; López-Canet M; Rosenbaum C; Rummey C; Thiemann M; Matassa VG; Edwards PJ; Feurer A
    Bioorg Med Chem Lett; 2009 Nov; 19(22):6340-5. PubMed ID: 19833514
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Design and synthesis of DPP-IV inhibitors lacking the electrophilic nitrile group.
    Kondo T; Nekado T; Sugimoto I; Ochi K; Takai S; Kinoshita A; Hatayama A; Yamamoto S; Kishikawa K; Nakai H; Toda M
    Bioorg Med Chem; 2008 Feb; 16(4):1613-31. PubMed ID: 18039579
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 17.