93 related articles for article (PubMed ID: 18347148)
1. Transient exposure of carcinoma cells to RAS/MEK inhibitors and UCN-01 causes cell death in vitro and in vivo.
Hamed H; Hawkins W; Mitchell C; Gilfor D; Zhang G; Pei XY; Dai Y; Hagan MP; Roberts JD; Yacoub A; Grant S; Dent P
Mol Cancer Ther; 2008 Mar; 7(3):616-29. PubMed ID: 18347148
[TBL] [Abstract][Full Text] [Related]
2. Transient exposure of mammary tumors to PD184352 and UCN-01 causes tumor cell death in vivo and prolonged suppression of tumor regrowth.
Hawkins W; Mitchell C; McKinstry R; Gilfor D; Starkey J; Dai Y; Dawson K; Ramakrishnan V; Roberts JD; Yacoub A; Grant S; Dent P
Cancer Biol Ther; 2005 Nov; 4(11):1275-84. PubMed ID: 16319524
[TBL] [Abstract][Full Text] [Related]
3. MEK1/2 inhibition promotes Taxotere lethality in mammary tumors in vivo.
Yacoub A; Gilfor D; Hawkins W; Park MA; Hanna D; Hagan MP; Curiel DT; Fisher PB; Grant S; Dent P
Cancer Biol Ther; 2006 Oct; 5(10):1332-9. PubMed ID: 16957420
[TBL] [Abstract][Full Text] [Related]
4. MEK1/2 inhibitors potentiate UCN-01 lethality in human multiple myeloma cells through a Bim-dependent mechanism.
Pei XY; Dai Y; Tenorio S; Lu J; Harada H; Dent P; Grant S
Blood; 2007 Sep; 110(6):2092-101. PubMed ID: 17540843
[TBL] [Abstract][Full Text] [Related]
5. Enhancing CHK1 inhibitor lethality in glioblastoma.
Tang Y; Dai Y; Grant S; Dent P
Cancer Biol Ther; 2012 Apr; 13(6):379-88. PubMed ID: 22313687
[TBL] [Abstract][Full Text] [Related]
6. Simultaneous exposure of transformed cells to SRC family inhibitors and CHK1 inhibitors causes cell death.
Mitchell C; Hamed HA; Cruickshanks N; Tang Y; Bareford MD; Hubbard N; Tye G; Yacoub A; Dai Y; Grant S; Dent P
Cancer Biol Ther; 2011 Aug; 12(3):215-28. PubMed ID: 21642769
[TBL] [Abstract][Full Text] [Related]
7. Inhibitors of MEK1/2 interact with UCN-01 to induce apoptosis and reduce colony formation in mammary and prostate carcinoma cells.
McKinstry R; Qiao L; Yacoub A; Dai Y; Decker R; Holt S; Hagan MP; Grant S; Dent P
Cancer Biol Ther; 2002; 1(3):243-53. PubMed ID: 12432271
[TBL] [Abstract][Full Text] [Related]
8. Dissecting the roles of checkpoint kinase 1/CDC2 and mitogen-activated protein kinase kinase 1/2/extracellular signal-regulated kinase 1/2 in relation to 7-hydroxystaurosporine-induced apoptosis in human multiple myeloma cells.
Pei XY; Li W; Dai Y; Dent P; Grant S
Mol Pharmacol; 2006 Dec; 70(6):1965-73. PubMed ID: 16940414
[TBL] [Abstract][Full Text] [Related]
9. Combined treatment with the checkpoint abrogator UCN-01 and MEK1/2 inhibitors potently induces apoptosis in drug-sensitive and -resistant myeloma cells through an IL-6-independent mechanism.
Dai Y; Landowski TH; Rosen ST; Dent P; Grant S
Blood; 2002 Nov; 100(9):3333-43. PubMed ID: 12384435
[TBL] [Abstract][Full Text] [Related]
10. Pharmacological inhibitors of the mitogen-activated protein kinase (MAPK) kinase/MAPK cascade interact synergistically with UCN-01 to induce mitochondrial dysfunction and apoptosis in human leukemia cells.
Dai Y; Yu C; Singh V; Tang L; Wang Z; McInistry R; Dent P; Grant S
Cancer Res; 2001 Jul; 61(13):5106-15. PubMed ID: 11431348
[TBL] [Abstract][Full Text] [Related]
11. Coadministration of UCN-01 with MEK1/2 inhibitors potently induces apoptosis in BCR/ABL+ leukemia cells sensitive and resistant to ST1571.
Yu C; Dai Y; Dent P; Grant S
Cancer Biol Ther; 2002; 1(6):674-82. PubMed ID: 12642693
[TBL] [Abstract][Full Text] [Related]
12. Mitogen-activated protein kinase kinase 1/2 inhibitors and 17-allylamino-17-demethoxygeldanamycin synergize to kill human gastrointestinal tumor cells in vitro via suppression of c-FLIP-s levels and activation of CD95.
Park MA; Zhang G; Mitchell C; Rahmani M; Hamed H; Hagan MP; Yacoub A; Curiel DT; Fisher PB; Grant S; Dent P
Mol Cancer Ther; 2008 Sep; 7(9):2633-48. PubMed ID: 18790746
[TBL] [Abstract][Full Text] [Related]
13. Interruption of the Ras/MEK/ERK signaling cascade enhances Chk1 inhibitor-induced DNA damage in vitro and in vivo in human multiple myeloma cells.
Dai Y; Chen S; Pei XY; Almenara JA; Kramer LB; Venditti CA; Dent P; Grant S
Blood; 2008 Sep; 112(6):2439-49. PubMed ID: 18614762
[TBL] [Abstract][Full Text] [Related]
14. Rapamycin and UCN-01 synergistically induce apoptosis in human leukemia cells through a process that is regulated by the Raf-1/MEK/ERK, Akt, and JNK signal transduction pathways.
Hahn M; Li W; Yu C; Rahmani M; Dent P; Grant S
Mol Cancer Ther; 2005 Mar; 4(3):457-70. PubMed ID: 15767555
[TBL] [Abstract][Full Text] [Related]
15. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) promotes mitochondrial dysfunction and apoptosis induced by 7-hydroxystaurosporine and mitogen-activated protein kinase kinase inhibitors in human leukemia cells that ectopically express Bcl-2 and Bcl-xL.
Dai Y; Dent P; Grant S
Mol Pharmacol; 2003 Dec; 64(6):1402-9. PubMed ID: 14645670
[TBL] [Abstract][Full Text] [Related]
16. Statins synergistically potentiate 7-hydroxystaurosporine (UCN-01) lethality in human leukemia and myeloma cells by disrupting Ras farnesylation and activation.
Dai Y; Khanna P; Chen S; Pei XY; Dent P; Grant S
Blood; 2007 May; 109(10):4415-23. PubMed ID: 17264303
[TBL] [Abstract][Full Text] [Related]
17. Antitumor effects of novel highly hydrophilic and non-ATP-competitive MEK1/2 inhibitor, SMK-17.
Kiga M; Tanzawa F; Iwasaki S; Inaba F; Fujiwara K; Iwadare H; Echigo T; Nakamura Y; Shibata T; Suzuki K; Yasumatsu I; Nakayama A; Sasazawa Y; Tashiro E; Imoto M; Kurakata S
Anticancer Drugs; 2012 Jan; 23(1):119-30. PubMed ID: 22008853
[TBL] [Abstract][Full Text] [Related]
18. Celecoxib enhances the radiosensitizing effect of 7-hydroxystaurosporine (UCN-01) in human lung cancer cell lines.
Kim YM; Jeong IH; Pyo H
Int J Radiat Oncol Biol Phys; 2012 Jul; 83(3):e399-407. PubMed ID: 22417802
[TBL] [Abstract][Full Text] [Related]
19. Combined antitumor activity of 7-hydroxystaurosporine (UCN-01) and tamoxifen against human breast carcinoma in vitro and in vivo.
Koh J; Kubota T; Koyama T; Migita T; Hashimoto M; Hosoda Y; Kitajima M
Breast Cancer; 2003; 10(3):260-7. PubMed ID: 12955040
[TBL] [Abstract][Full Text] [Related]
20. The effect of UCN-01 (7-hydroxystaurosporine), a potent inhibitor of protein kinase C, on fractionated radiotherapy or daily chemotherapy of a murine fibrosarcoma.
Tsuchida E; Urano M
Int J Radiat Oncol Biol Phys; 1997 Dec; 39(5):1153-61. PubMed ID: 9392558
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
