BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

159 related articles for article (PubMed ID: 18354055)

  • 1. Comparative molecular field analysis using selectivity fields reveals residues in the third transmembrane helix of the serotonin transporter associated with substrate and antagonist recognition.
    Walline CC; Nichols DE; Carroll FI; Barker EL
    J Pharmacol Exp Ther; 2008 Jun; 325(3):791-800. PubMed ID: 18354055
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Tyr-95 and Ile-172 in transmembrane segments 1 and 3 of human serotonin transporters interact to establish high affinity recognition of antidepressants.
    Henry LK; Field JR; Adkins EM; Parnas ML; Vaughan RA; Zou MF; Newman AH; Blakely RD
    J Biol Chem; 2006 Jan; 281(4):2012-23. PubMed ID: 16272152
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Engineered zinc-binding sites confirm proximity and orientation of transmembrane helices I and III in the human serotonin transporter.
    White KJ; Kiser PD; Nichols DE; Barker EL
    Protein Sci; 2006 Oct; 15(10):2411-22. PubMed ID: 17008722
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Conformational flexibility of transmembrane helix VII of the human serotonin transporter impacts ion dependence and transport.
    Wenthur CJ; Rodríguez GJ; Kuntz CP; Barker EL
    Biochem Pharmacol; 2010 Nov; 80(9):1418-26. PubMed ID: 20637736
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Distinct molecular recognition of psychostimulants by human and Drosophila serotonin transporters.
    Roman DL; Saldaña SN; Nichols DE; Carroll FI; Barker EL
    J Pharmacol Exp Ther; 2004 Feb; 308(2):679-87. PubMed ID: 14593087
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Y95 and E444 interaction required for high-affinity S-citalopram binding in the human serotonin transporter.
    Combs S; Kaufmann K; Field JR; Blakely RD; Meiler J
    ACS Chem Neurosci; 2011 Feb; 2(2):75-81. PubMed ID: 22778858
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Helix XI contributes to the entrance of the serotonin transporter permeation pathway.
    Torres-Altoro MI; White KJ; Rodríguez GJ; Nichols DE; Barker EL
    Protein Sci; 2008 Oct; 17(10):1761-70. PubMed ID: 18628241
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structural determinants of species-selective substrate recognition in human and Drosophila serotonin transporters revealed through computational docking studies.
    Kaufmann KW; Dawson ES; Henry LK; Field JR; Blakely RD; Meiler J
    Proteins; 2009 Feb; 74(3):630-42. PubMed ID: 18704946
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The external gate of the human and Drosophila serotonin transporters requires a basic/acidic amino acid pair for 3,4-methylenedioxymethamphetamine (MDMA) translocation and the induction of substrate efflux.
    Sealover NR; Felts B; Kuntz CP; Jarrard RE; Hockerman GH; Lamb PW; Barker EL; Henry LK
    Biochem Pharmacol; 2016 Nov; 120():46-55. PubMed ID: 27638414
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Location of the antidepressant binding site in the serotonin transporter: importance of Ser-438 in recognition of citalopram and tricyclic antidepressants.
    Andersen J; Taboureau O; Hansen KB; Olsen L; Egebjerg J; Strømgaard K; Kristensen AS
    J Biol Chem; 2009 Apr; 284(15):10276-84. PubMed ID: 19213730
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Binding of the multimodal antidepressant drug vortioxetine to the human serotonin transporter.
    Andersen J; Ladefoged LK; Wang D; Kristensen TN; Bang-Andersen B; Kristensen AS; Schiøtt B; Strømgaard K
    ACS Chem Neurosci; 2015 Nov; 6(11):1892-900. PubMed ID: 26389667
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Mutational mapping and modeling of the binding site for (S)-citalopram in the human serotonin transporter.
    Andersen J; Olsen L; Hansen KB; Taboureau O; Jørgensen FS; Jørgensen AM; Bang-Andersen B; Egebjerg J; Strømgaard K; Kristensen AS
    J Biol Chem; 2010 Jan; 285(3):2051-63. PubMed ID: 19892699
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structural analysis of the extracellular entrance to the serotonin transporter permeation pathway.
    Torres-Altoro MI; Kuntz CP; Nichols DE; Barker EL
    J Biol Chem; 2010 May; 285(20):15369-15379. PubMed ID: 20304925
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Allosteric effects of R- and S-citalopram on the human 5-HT transporter: evidence for distinct high- and low-affinity binding sites.
    Plenge P; Gether U; Rasmussen SG
    Eur J Pharmacol; 2007 Jul; 567(1-2):1-9. PubMed ID: 17499240
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Transmembrane domain 6 of the human serotonin transporter contributes to an aqueously accessible binding pocket for serotonin and the psychostimulant 3,4-methylene dioxymethamphetamine.
    Field JR; Henry LK; Blakely RD
    J Biol Chem; 2010 Apr; 285(15):11270-80. PubMed ID: 20159976
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Species-scanning mutagenesis of the serotonin transporter reveals residues essential in selective, high-affinity recognition of antidepressants.
    Mortensen OV; Kristensen AS; Wiborg O
    J Neurochem; 2001 Oct; 79(2):237-47. PubMed ID: 11677251
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Binding and orientation of tricyclic antidepressants within the central substrate site of the human serotonin transporter.
    Sinning S; Musgaard M; Jensen M; Severinsen K; Celik L; Koldsø H; Meyer T; Bols M; Jensen HH; Schiøtt B; Wiborg O
    J Biol Chem; 2010 Mar; 285(11):8363-74. PubMed ID: 19948720
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Substrate and Inhibitor-Specific Conformational Changes in the Human Serotonin Transporter Revealed by Voltage-Clamp Fluorometry.
    Söderhielm PC; Andersen J; Munro L; Nielsen AT; Kristensen AS
    Mol Pharmacol; 2015 Oct; 88(4):676-88. PubMed ID: 26174773
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Interaction of antidepressants with the serotonin and norepinephrine transporters: mutational studies of the S1 substrate binding pocket.
    Sørensen L; Andersen J; Thomsen M; Hansen SM; Zhao X; Sandelin A; Strømgaard K; Kristensen AS
    J Biol Chem; 2012 Dec; 287(52):43694-707. PubMed ID: 23086945
    [TBL] [Abstract][Full Text] [Related]  

  • 20. High affinity recognition of serotonin transporter antagonists defined by species-scanning mutagenesis. An aromatic residue in transmembrane domain I dictates species-selective recognition of citalopram and mazindol.
    Barker EL; Perlman MA; Adkins EM; Houlihan WJ; Pristupa ZB; Niznik HB; Blakely RD
    J Biol Chem; 1998 Jul; 273(31):19459-68. PubMed ID: 9677366
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.