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4. Biodistribution of an antibody-enzyme conjugate for antibody-directed enzyme prodrug therapy in nude mice bearing a human colon adenocarcinoma xenograft. Stribbling SM; Martin J; Pedley RB; Boden JA; Sharma SK; Springer CJ Cancer Chemother Pharmacol; 1997; 40(4):277-84. PubMed ID: 9225945 [TBL] [Abstract][Full Text] [Related]
5. Novel prodrugs which are activated to cytotoxic alkylating agents by carboxypeptidase G2. Springer CJ; Antoniw P; Bagshawe KD; Searle F; Bisset GM; Jarman M J Med Chem; 1990 Feb; 33(2):677-81. PubMed ID: 2299634 [TBL] [Abstract][Full Text] [Related]
6. The potential of carboxypeptidase G2: antibody conjugates as anti-tumour agents. II. In vivo localising and clearance properties in a choriocarcinoma model. Melton RG; Searle F; Sherwood RF; Bagshawe KD; Boden JA Br J Cancer; 1990 Mar; 61(3):420-4. PubMed ID: 2328209 [TBL] [Abstract][Full Text] [Related]
7. Enhancement of antibody-directed enzyme prodrug therapy in colorectal xenografts by an antivascular agent. Pedley RB; Sharma SK; Boxer GM; Boden R; Stribbling SM; Davies L; Springer CJ; Begent RH Cancer Res; 1999 Aug; 59(16):3998-4003. PubMed ID: 10463598 [TBL] [Abstract][Full Text] [Related]
8. Novel prodrugs of alkylating agents derived from 2-fluoro- and 3-fluorobenzoic acids for antibody-directed enzyme prodrug therapy. Springer CJ; Niculescu-Duvaz I; Pedley RB J Med Chem; 1994 Jul; 37(15):2361-70. PubMed ID: 8057284 [TBL] [Abstract][Full Text] [Related]
9. Disposition of the prodrug 4-(bis (2-chloroethyl) amino) benzoyl-L-glutamic acid and its active parent drug in mice. Antoniw P; Springer CJ; Bagshawe KD; Searle F; Melton RG; Rogers GT; Burke PJ; Sherwood RF Br J Cancer; 1990 Dec; 62(6):909-14. PubMed ID: 2257218 [TBL] [Abstract][Full Text] [Related]
10. A phase I trial of antibody directed enzyme prodrug therapy (ADEPT) in patients with advanced colorectal carcinoma or other CEA producing tumours. Francis RJ; Sharma SK; Springer C; Green AJ; Hope-Stone LD; Sena L; Martin J; Adamson KL; Robbins A; Gumbrell L; O'Malley D; Tsiompanou E; Shahbakhti H; Webley S; Hochhauser D; Hilson AJ; Blakey D; Begent RH Br J Cancer; 2002 Sep; 87(6):600-7. PubMed ID: 12237768 [TBL] [Abstract][Full Text] [Related]
11. Optimization of alkylating agent prodrugs derived from phenol and aniline mustards: a new clinical candidate prodrug (ZD2767) for antibody-directed enzyme prodrug therapy (ADEPT). Springer CJ; Dowell R; Burke PJ; Hadley E; Davis DH; Blakey DC; Melton RG; Niculescu-Duvaz I J Med Chem; 1995 Dec; 38(26):5051-65. PubMed ID: 8544182 [TBL] [Abstract][Full Text] [Related]
13. Antibody-directed enzyme prodrug therapy (ADEPT) with mustard prodrugs. Springer CJ; Niculescu-Duvaz I Anticancer Drug Des; 1995 Jul; 10(5):361-72. PubMed ID: 7639927 [TBL] [Abstract][Full Text] [Related]
14. Plasma clearance of an antibody--enzyme conjugate in ADEPT by monoclonal anti-enzyme: its effect on prodrug activation in vivo. Rogers GT; Burke PJ; Sharma SK; Koodie R; Boden JA Br J Cancer; 1995 Dec; 72(6):1357-63. PubMed ID: 8519645 [TBL] [Abstract][Full Text] [Related]
15. Measurement of the critical DNA lesions produced by antibody-directed enzyme prodrug therapy (ADEPT) in vitro, in vivo and in clinical material. Webley SD; Francis RJ; Pedley RB; Sharma SK; Begent RH; Hartley JA; Hochhauser D Br J Cancer; 2001 Jun; 84(12):1671-6. PubMed ID: 11401322 [TBL] [Abstract][Full Text] [Related]
16. Comparison of half-lives and cytotoxicity of N-chloroethyl-4-amino and N-mesyloxyethyl-benzoyl compounds, products of prodrugs in antibody-directed enzyme prodrug therapy (ADEPT). Springer CJ; Antoniw P; Bagshawe KD; Wilman DE Anticancer Drug Des; 1991 Nov; 6(5):467-79. PubMed ID: 1764165 [TBL] [Abstract][Full Text] [Related]
17. Antitumor effects of an antibody-carboxypeptidase G2 conjugate in combination with a benzoic acid mustard prodrug. Blakey DC; Valcaccia BE; East S; Wright AF; Boyle FT; Springer CJ; Burke PJ; Melton RG; Bagshawe KD Cell Biophys; 1993; 22(1-3):1-8. PubMed ID: 7889535 [TBL] [Abstract][Full Text] [Related]
18. Regression of established breast carcinoma xenografts with antibody-directed enzyme prodrug therapy against c-erbB2 p185. Eccles SA; Court WJ; Box GA; Dean CJ; Melton RG; Springer CJ Cancer Res; 1994 Oct; 54(19):5171-7. PubMed ID: 7923136 [TBL] [Abstract][Full Text] [Related]
19. Antibody-directed enzyme prodrug therapy: pharmacokinetics and plasma levels of prodrug and drug in a phase I clinical trial. Martin J; Stribbling SM; Poon GK; Begent RH; Napier M; Sharma SK; Springer CJ Cancer Chemother Pharmacol; 1997; 40(3):189-201. PubMed ID: 9219501 [TBL] [Abstract][Full Text] [Related]