These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

212 related articles for article (PubMed ID: 18359633)

  • 1. Alkyne-quinuclidine derivatives as potent and selective muscarinic antagonists for the treatment of COPD.
    Starck JP; Provins L; Christophe B; Gillard M; Jadot S; Lo Brutto P; Quéré L; Talaga P; Guyaux M
    Bioorg Med Chem Lett; 2008 Apr; 18(8):2675-8. PubMed ID: 18359633
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The discovery of AZD9164, a novel muscarinic M3 antagonist.
    Mete A; Bowers K; Chevalier E; Donald DK; Edwards H; Escott KJ; Ford R; Grime K; Millichip I; Teobald B; Russell V
    Bioorg Med Chem Lett; 2011 Dec; 21(24):7440-6. PubMed ID: 22047691
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Potent anti-muscarinic activity in a novel series of quinuclidine derivatives.
    Starck JP; Talaga P; Quéré L; Collart P; Christophe B; Lo Brutto P; Jadot S; Chimmanamada D; Zanda M; Wagner A; Mioskowski C; Massingham R; Guyaux M
    Bioorg Med Chem Lett; 2006 Jan; 16(2):373-7. PubMed ID: 16275087
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinol esters as potent and long-acting muscarinic antagonists with potential for minimal systemic exposure after inhaled administration: identification of (3R)-3-{[hydroxy(di-2-thienyl)acetyl]oxy}-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide (aclidinium bromide).
    Prat M; Fernández D; Buil MA; Crespo MI; Casals G; Ferrer M; Tort L; Castro J; Monleón JM; Gavaldà A; Miralpeix M; Ramos I; Doménech T; Vilella D; Antón F; Huerta JM; Espinosa S; López M; Sentellas S; González M; Albertí J; Segarra V; Cárdenas A; Beleta J; Ryder H
    J Med Chem; 2009 Aug; 52(16):5076-92. PubMed ID: 19653626
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis and antimuscarinic properties of quinuclidin-3-yl 1,2,3,4-tetrahydroisoquinoline-2-carboxylate derivatives as novel muscarinic receptor antagonists.
    Naito R; Yonetoku Y; Okamoto Y; Toyoshima A; Ikeda K; Takeuchi M
    J Med Chem; 2005 Oct; 48(21):6597-606. PubMed ID: 16220976
    [TBL] [Abstract][Full Text] [Related]  

  • 6. First dual M3 antagonists-PDE4 inhibitors: synthesis and SAR of 4,6-diaminopyrimidine derivatives.
    Provins L; Christophe B; Danhaive P; Dulieu J; Durieu V; Gillard M; Lebon F; Lengelé S; Quéré L; van Keulen B
    Bioorg Med Chem Lett; 2006 Apr; 16(7):1834-9. PubMed ID: 16439121
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinyl carbamates as potent and long acting muscarinic antagonists.
    Prat M; Buil MA; Fernández MD; Castro J; Monleón JM; Tort L; Casals G; Ferrer M; Huerta JM; Espinosa S; López M; Segarra V; Gavaldà A; Miralpeix M; Ramos I; Vilella D; González M; Córdoba M; Cárdenas A; Antón F; Beleta J; Ryder H
    Bioorg Med Chem Lett; 2011 Jun; 21(11):3457-61. PubMed ID: 21524581
    [TBL] [Abstract][Full Text] [Related]  

  • 8. 3-(2-Benzofuranyl)quinuclidin-2-ene derivatives: novel muscarinic antagonists.
    Nordvall G; Sundquist S; Johansson G; Glas G; Nilvebrant L; Hacksell U
    J Med Chem; 1996 Aug; 39(17):3269-77. PubMed ID: 8765510
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Isopropyl amide derivatives of potent and selective muscarinic M2 receptor antagonists.
    Palani A; Dugar S; Clader JW; Greenlee WJ; Ruperto V; Duffy RA; Lachowicz JE
    Bioorg Med Chem Lett; 2004 Apr; 14(7):1791-4. PubMed ID: 15026073
    [TBL] [Abstract][Full Text] [Related]  

  • 10. [Regulation of bronchial tone in chronic obstructive pulmonary disease (COPD): role of muscarinic receptors].
    Abad Santos F; Novalbos J; Gallego Sandín S; Gálvez Múgica MA
    An Med Interna; 2003 Apr; 20(4):201-5. PubMed ID: 12768836
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Discovery of novel 1-azoniabicyclo[2.2.2]octane muscarinic acetylcholine receptor antagonists.
    Lainé DI; McCleland B; Thomas S; Neipp C; Underwood B; Dufour J; Widdowson KL; Palovich MR; Blaney FE; Foley JJ; Webb EF; Luttmann MA; Burman M; Belmonte K; Salmon M
    J Med Chem; 2009 Apr; 52(8):2493-505. PubMed ID: 19317446
    [TBL] [Abstract][Full Text] [Related]  

  • 12. 3-Heteroarylquinuclidin-2-ene derivatives as muscarinic antagonists: synthesis, structure-activity relationships and molecular modelling.
    Nordvall G; Nilsson BM; Sundquist S; Johansson G; Glas G; Nilvebrant L; Hacksell U
    Prog Brain Res; 1996; 109():141-5. PubMed ID: 9009700
    [No Abstract]   [Full Text] [Related]  

  • 13. The effect of absolute configuration on activity, subtype selectivity (M3/M2) of 3α-acyloxy-6β-acetoxyltropane derivatives as muscarinic M3 receptor antagonists.
    Wang ZP; Liu HZ; Zhu L; Hu YM; Cui YY; Niu YY; Lu Y; Chen HZ
    Bioorg Med Chem; 2013 Mar; 21(5):1234-9. PubMed ID: 23375092
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Novel muscarinic acetylcholine receptor hybrid ligands embedding quinuclidine and 1,4-dioxane fragments.
    Del Bello F; Bonifazi A; Giorgioni G; Petrelli R; Quaglia W; Altomare A; Falcicchio A; Matucci R; Vistoli G; Piergentili A
    Eur J Med Chem; 2017 Sep; 137():327-337. PubMed ID: 28609709
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinyl amides as potent and long acting muscarinic antagonists.
    Prat M; Buil MA; Fernández MD; Tort L; Monleón JM; Casals G; Ferrer M; Castro J; Gavaldà A; Miralpeix M; Ramos I; Vilella D; Huerta JM; Espinosa S; Hernández B; Segarra V; Córdoba M
    Bioorg Med Chem Lett; 2015 Apr; 25(8):1736-1741. PubMed ID: 25800115
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis and optimization of novel and selective muscarinic M(3) receptor antagonists.
    Kumar N; Kaur K; Aeron S; Dharmarajan S; Silamkoti AD; Mehta A; Gupta S; Chugh A; Gupta JB; Salman M; Palle VP; Cliffe IA
    Bioorg Med Chem Lett; 2007 Sep; 17(18):5256-60. PubMed ID: 17629699
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Novel quinuclidinyl heteroarylcarbamate derivatives as muscarinic receptor antagonists.
    Nagashima S; Matsushima Y; Hamaguchi H; Nagata H; Kontani T; Moritomo A; Koshika T; Takeuchi M
    Bioorg Med Chem; 2014 Jul; 22(13):3478-87. PubMed ID: 24837158
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Multivalent dual pharmacology muscarinic antagonist and β₂ agonist (MABA) molecules for the treatment of COPD.
    Hughes AD; McNamara A; Steinfeld T
    Prog Med Chem; 2012; 51():71-95. PubMed ID: 22520472
    [No Abstract]   [Full Text] [Related]  

  • 19. Comparison of muscarinic receptor selectivity of solifenacin and oxybutynin in the bladder and submandibular gland of muscarinic receptor knockout mice.
    Ito Y; Oyunzul L; Yoshida A; Fujino T; Noguchi Y; Yuyama H; Ohtake A; Suzuki M; Sasamata M; Matsui M; Yamada S
    Eur J Pharmacol; 2009 Aug; 615(1-3):201-6. PubMed ID: 19446545
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Efficient conversion of a nonselective norepinephrin reuptake inhibitor into a dual muscarinic antagonist-β₂-agonist for the treatment of chronic obstructive pulmonary disease.
    Osborne R; Clarke N; Glossop P; Kenyon A; Liu H; Patel S; Summerhill S; Jones LH
    J Med Chem; 2011 Oct; 54(19):6998-7002. PubMed ID: 21863888
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.