These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

181 related articles for article (PubMed ID: 18381626)

  • 1. A poke in the eye: inhibiting HIV-1 protease through its flap-recognition pocket.
    Damm KL; Ung PM; Quintero JJ; Gestwicki JE; Carlson HA
    Biopolymers; 2008 Aug; 89(8):643-52. PubMed ID: 18381626
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structural analysis of lead fullerene-based inhibitor bound to human immunodeficiency virus type 1 protease in solution from molecular dynamics simulations.
    Lee VS; Nimmanpipug P; Aruksakunwong O; Promsri S; Sompornpisut P; Hannongbua S
    J Mol Graph Model; 2007 Sep; 26(2):558-70. PubMed ID: 17468026
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Flap opening in HIV-1 protease simulated by 'activated' molecular dynamics.
    Collins JR; Burt SK; Erickson JW
    Nat Struct Biol; 1995 Apr; 2(4):334-8. PubMed ID: 7796268
    [TBL] [Abstract][Full Text] [Related]  

  • 4. HIV-1 protease flaps spontaneously close to the correct structure in simulations following manual placement of an inhibitor into the open state.
    Hornak V; Okur A; Rizzo RC; Simmerling C
    J Am Chem Soc; 2006 Mar; 128(9):2812-3. PubMed ID: 16506755
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Molecular dynamics simulations of ligand-induced flap closing in HIV-1 protease approach X-ray resolution: establishing the role of bound water in the flap closing mechanism.
    Singh G; Senapati S
    Biochemistry; 2008 Oct; 47(40):10657-64. PubMed ID: 18785756
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Targeting dynamic pockets of HIV-1 protease by structure-based computational screening for allosteric inhibitors.
    Kunze J; Todoroff N; Schneider P; Rodrigues T; Geppert T; Reisen F; Schreuder H; Saas J; Hessler G; Baringhaus KH; Schneider G
    J Chem Inf Model; 2014 Mar; 54(3):987-91. PubMed ID: 24528206
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Binding to the open conformation of HIV-1 protease.
    Lexa KW; Carlson HA
    Proteins; 2011 Jul; 79(7):2282-90. PubMed ID: 21604303
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Solvation influences flap collapse in HIV-1 protease.
    Meagher KL; Carlson HA
    Proteins; 2005 Jan; 58(1):119-25. PubMed ID: 15521062
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Drug pressure selected mutations in HIV-1 protease alter flap conformations.
    Galiano L; Ding F; Veloro AM; Blackburn ME; Simmerling C; Fanucci GE
    J Am Chem Soc; 2009 Jan; 131(2):430-1. PubMed ID: 19140783
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Dynamics of "flap" structures in three HIV-1 protease/inhibitor complexes probed by total chemical synthesis and pulse-EPR spectroscopy.
    Torbeev VY; Raghuraman H; Mandal K; Senapati S; Perozo E; Kent SB
    J Am Chem Soc; 2009 Jan; 131(3):884-5. PubMed ID: 19117390
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Incorporating protein flexibility in structure-based drug discovery: using HIV-1 protease as a test case.
    Meagher KL; Carlson HA
    J Am Chem Soc; 2004 Oct; 126(41):13276-81. PubMed ID: 15479081
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A molecular dynamics study comparing a wild-type with a multiple drug resistant HIV protease: differences in flap and aspartate 25 cavity dimensions.
    Seibold SA; Cukier RI
    Proteins; 2007 Nov; 69(3):551-65. PubMed ID: 17623840
    [TBL] [Abstract][Full Text] [Related]  

  • 13. HIV-1 protease flaps spontaneously open and reclose in molecular dynamics simulations.
    Hornak V; Okur A; Rizzo RC; Simmerling C
    Proc Natl Acad Sci U S A; 2006 Jan; 103(4):915-20. PubMed ID: 16418268
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Explicit solvent dynamics and energetics of HIV-1 protease flap opening and closing.
    Sadiq SK; De Fabritiis G
    Proteins; 2010 Nov; 78(14):2873-85. PubMed ID: 20715057
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Small molecule regulation of protein conformation by binding in the Flap of HIV protease.
    Tiefenbrunn T; Forli S; Baksh MM; Chang MW; Happer M; Lin YC; Perryman AL; Rhee JK; Torbett BE; Olson AJ; Elder JH; Finn MG; Stout CD
    ACS Chem Biol; 2013; 8(6):1223-31. PubMed ID: 23540839
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Flap-site Fragment Restores Back Wild-type Behaviour in Resistant Form of HIV Protease.
    Luchi A; Angelina E; Bogado L; Forli S; Olson A; Peruchena N
    Mol Inform; 2018 Dec; 37(12):e1800053. PubMed ID: 30051611
    [TBL] [Abstract][Full Text] [Related]  

  • 17. [Biosensor analysis of interaction of potential dimerization inhibitors with HIV-1 protease].
    Ershov PV; Gnedenko OV; Mol'nar AA; Lisitsa AV; Ivanov AS; Archakov AI
    Biomed Khim; 2009; 55(4):462-78. PubMed ID: 20000124
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Dynamic flaps in HIV-1 protease adopt unique ordering at different stages in the catalytic cycle.
    Karthik S; Senapati S
    Proteins; 2011 Jun; 79(6):1830-40. PubMed ID: 21465560
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Effect of flap mutations on structure of HIV-1 protease and inhibition by saquinavir and darunavir.
    Liu F; Kovalevsky AY; Tie Y; Ghosh AK; Harrison RW; Weber IT
    J Mol Biol; 2008 Aug; 381(1):102-15. PubMed ID: 18597780
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Molecular dynamics and ligand docking of a hinge region variant of South African HIV-1 subtype C protease.
    Zondagh J; Balakrishnan V; Achilonu I; Dirr HW; Sayed Y
    J Mol Graph Model; 2018 Jun; 82():1-11. PubMed ID: 29625416
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.