These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

181 related articles for article (PubMed ID: 18381626)

  • 21. An alternate binding site for the P1-P3 group of a class of potent HIV-1 protease inhibitors as a result of concerted structural change in the 80s loop of the protease.
    Munshi S; Chen Z; Yan Y; Li Y; Olsen DB; Schock HB; Galvin BB; Dorsey B; Kuo LC
    Acta Crystallogr D Biol Crystallogr; 2000 Apr; 56(Pt 4):381-8. PubMed ID: 10739910
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Parallel screening and activity profiling with HIV protease inhibitor pharmacophore models.
    Steindl TM; Schuster D; Laggner C; Chuang K; Hoffmann RD; Langer T
    J Chem Inf Model; 2007; 47(2):563-71. PubMed ID: 17381173
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Interdependence of Inhibitor Recognition in HIV-1 Protease.
    Paulsen JL; Leidner F; Ragland DA; Kurt Yilmaz N; Schiffer CA
    J Chem Theory Comput; 2017 May; 13(5):2300-2309. PubMed ID: 28358514
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Structural insights into the South African HIV-1 subtype C protease: impact of hinge region dynamics and flap flexibility in drug resistance.
    Naicker P; Achilonu I; Fanucchi S; Fernandes M; Ibrahim MA; Dirr HW; Soliman ME; Sayed Y
    J Biomol Struct Dyn; 2013 Dec; 31(12):1370-80. PubMed ID: 23140382
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Triterpenes as potential dimerization inhibitors of HIV-1 protease.
    Quéré L; Wenger T; Schramm HJ
    Biochem Biophys Res Commun; 1996 Oct; 227(2):484-8. PubMed ID: 8967903
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Novel strategies for targeting the dimerization interface of HIV protease with cross-linked interfacial peptides.
    Bowman MJ; Chmielewski J
    Biopolymers; 2002; 66(2):126-33. PubMed ID: 12325162
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Refining the multiple protein structure pharmacophore method: consistency across three independent HIV-1 protease models.
    Meagher KL; Lerner MG; Carlson HA
    J Med Chem; 2006 Jun; 49(12):3478-84. PubMed ID: 16759090
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Structural and binding insights into HIV-1 protease and P2-ligand interactions through molecular dynamics simulations, binding free energy and principal component analysis.
    Karnati KR; Wang Y
    J Mol Graph Model; 2019 Nov; 92():112-122. PubMed ID: 31351319
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Inhibition of HIV-1 protease: the rigidity perspective.
    Heal JW; Jimenez-Roldan JE; Wells SA; Freedman RB; Römer RA
    Bioinformatics; 2012 Feb; 28(3):350-7. PubMed ID: 22291339
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Strength of hydrogen bond network takes crucial roles in the dissociation process of inhibitors from the HIV-1 protease binding pocket.
    Li D; Ji B; Hwang KC; Huang Y
    PLoS One; 2011 Apr; 6(4):e19268. PubMed ID: 21559397
    [TBL] [Abstract][Full Text] [Related]  

  • 31. HIV-1 Protease Dimerization Dynamics Reveals a Transient Druggable Binding Pocket at the Interface.
    Pietrucci F; Vargiu AV; Kranjc A
    Sci Rep; 2015 Dec; 5():18555. PubMed ID: 26692118
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Exploration of the structural requirements of HIV-protease inhibitors using pharmacophore, virtual screening and molecular docking approaches for lead identification.
    Islam MA; Pillay TS
    J Mol Graph Model; 2015 Mar; 56():20-30. PubMed ID: 25541527
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Synthetic, structural mimetics of the β-hairpin flap of HIV-1 protease inhibit enzyme function.
    Chauhan J; Chen SE; Fenstermacher KJ; Naser-Tavakolian A; Reingewertz T; Salmo R; Lee C; Williams E; Raje M; Sundberg E; DeStefano JJ; Freire E; Fletcher S
    Bioorg Med Chem; 2015 Nov; 23(21):7095-109. PubMed ID: 26474665
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Multi-drug resistance profile of PR20 HIV-1 protease is attributed to distorted conformational and drug binding landscape: molecular dynamics insights.
    Chetty S; Bhakat S; Martin AJ; Soliman ME
    J Biomol Struct Dyn; 2016; 34(1):135-51. PubMed ID: 25671669
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Structure of HOE/BAY 793 complexed to human immunodeficiency virus (HIV-1) protease in two different crystal forms--structure/function relationship and influence of crystal packing.
    Lange-Savage G; Berchtold H; Liesum A; Budt KH; Peyman A; Knolle J; Sedlacek J; Fabry M; Hilgenfeld R
    Eur J Biochem; 1997 Sep; 248(2):313-22. PubMed ID: 9346283
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Evaluation of triazolamers as active site inhibitors of HIV-1 protease.
    Jochim AL; Miller SE; Angelo NG; Arora PS
    Bioorg Med Chem Lett; 2009 Nov; 19(21):6023-6. PubMed ID: 19800230
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Beta-lactam compounds as apparently uncompetitive inhibitors of HIV-1 protease.
    Sperka T; Pitlik J; Bagossi P; Tözsér J
    Bioorg Med Chem Lett; 2005 Jun; 15(12):3086-90. PubMed ID: 15893929
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Relation between sequence and structure of HIV-1 protease inhibitor complexes: a model system for the analysis of protein flexibility.
    Zoete V; Michielin O; Karplus M
    J Mol Biol; 2002 Jan; 315(1):21-52. PubMed ID: 11771964
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Mechanism of the Association Pathways for a Pair of Fast and Slow Binding Ligands of HIV-1 Protease.
    Huang YM; Raymundo MA; Chen W; Chang CA
    Biochemistry; 2017 Mar; 56(9):1311-1323. PubMed ID: 28060481
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Sidechain-linked inhibitors of HIV-1 protease dimerization.
    Bowman MJ; Chmielewski J
    Bioorg Med Chem; 2009 Feb; 17(3):967-76. PubMed ID: 18337105
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 10.