These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

203 related articles for article (PubMed ID: 18381815)

  • 21. Extended hormone binding site of the human thyroid stimulating hormone receptor: distinctive acidic residues in the hinge region are involved in bovine thyroid stimulating hormone binding and receptor activation.
    Mueller S; Kleinau G; Jaeschke H; Paschke R; Krause G
    J Biol Chem; 2008 Jun; 283(26):18048-55. PubMed ID: 18441013
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Molecular and structural effects of inverse agonistic mutations on signaling of the thyrotropin receptor--a basally active GPCR.
    Kleinau G; Jaeschke H; Mueller S; Worth CL; Paschke R; Krause G
    Cell Mol Life Sci; 2008 Nov; 65(22):3664-76. PubMed ID: 18850313
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Somatic mutations causing constitutive activity of the thyrotropin receptor are the major cause of hyperfunctioning thyroid adenomas: identification of additional mutations activating both the cyclic adenosine 3',5'-monophosphate and inositol phosphate-Ca2+ cascades.
    Parma J; Van Sande J; Swillens S; Tonacchera M; Dumont J; Vassart G
    Mol Endocrinol; 1995 Jun; 9(6):725-33. PubMed ID: 8592518
    [TBL] [Abstract][Full Text] [Related]  

  • 24. A free carboxylate oxygen in the side chain of position 674 in transmembrane domain 7 is necessary for TSH receptor activation.
    Neumann S; Krause G; Chey S; Paschke R
    Mol Endocrinol; 2001 Aug; 15(8):1294-305. PubMed ID: 11463854
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Molecular Insights into the Transmembrane Domain of the Thyrotropin Receptor.
    Chantreau V; Taddese B; Munier M; Gourdin L; Henrion D; Rodien P; Chabbert M
    PLoS One; 2015; 10(11):e0142250. PubMed ID: 26545118
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Insight into thyroid-stimulating autoantibody interaction with the thyrotropin receptor N-terminus based on mutagenesis and re-evaluation of ambiguity in this region of the receptor crystal structure.
    Hamidi S; Chen CR; McLachlan SM; Rapoport B
    Thyroid; 2011 Sep; 21(9):1013-20. PubMed ID: 21834684
    [TBL] [Abstract][Full Text] [Related]  

  • 27. A conserved Asn in transmembrane helix 7 is an on/off switch in the activation of the thyrotropin receptor.
    Govaerts C; Lefort A; Costagliola S; Wodak SJ; Ballesteros JA; Van Sande J; Pardo L; Vassart G
    J Biol Chem; 2001 Jun; 276(25):22991-9. PubMed ID: 11312274
    [TBL] [Abstract][Full Text] [Related]  

  • 28. New pathogenic thyrotropin receptor mutations decipher differentiated activity switching at a conserved helix 6 motif of family A GPCR.
    Biebermann H; Winkler F; Handke D; Teichmann A; Gerling B; Cameron F; Eichhorst J; Grüters A; Wiesner B; Kühnen P; Krude H; Kleinau G
    J Clin Endocrinol Metab; 2012 Feb; 97(2):E228-32. PubMed ID: 22112806
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Rearrangement of the Extracellular Domain/Extracellular Loop 1 Interface Is Critical for Thyrotropin Receptor Activation.
    Schaarschmidt J; Nagel MBM; Huth S; Jaeschke H; Moretti R; Hintze V; von Bergen M; Kalkhof S; Meiler J; Paschke R
    J Biol Chem; 2016 Jul; 291(27):14095-14108. PubMed ID: 27129207
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Site-directed mutagenesis of amino acids 33-44 of the common alpha-subunit reveals different structural requirements for heterodimer expression among the glycoprotein hormones and suggests that cyclic adenosine 3',5'-monophosphate production and growth promotion are potentially dissociable functions of human thyrotropin.
    Grossmann M; Szkudlinski MW; Dias JA; Xia H; Wong R; Puett D; Weintraub BD
    Mol Endocrinol; 1996 Jun; 10(6):769-79. PubMed ID: 8776737
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Mutations that silence constitutive signaling activity in the allosteric ligand-binding site of the thyrotropin receptor.
    Haas AK; Kleinau G; Hoyer I; Neumann S; Furkert J; Rutz C; Schülein R; Gershengorn MC; Krause G
    Cell Mol Life Sci; 2011 Jan; 68(1):159-67. PubMed ID: 20652618
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Identification of separate determinants on the thyrotropin receptor reactive with Graves' thyroid-stimulating antibodies and with thyroid-stimulating blocking antibodies in idiopathic myxedema: these determinants have no homologous sequence on gonadotropin receptors.
    Kosugi S; Ban T; Akamizu T; Kohn LD
    Mol Endocrinol; 1992 Feb; 6(2):168-80. PubMed ID: 1349156
    [TBL] [Abstract][Full Text] [Related]  

  • 33. A conserved Asn in TM7 of the thyrotropin receptor is a common requirement for activation by both mutations and its natural agonist.
    Claeysen S; Govaerts C; Lefort A; Van Sande J; Costagliola S; Pardo L; Vassart G
    FEBS Lett; 2002 Apr; 517(1-3):195-200. PubMed ID: 12062436
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Importance of the extracellular domain of the human thyrotrophin receptor for activation of cyclic AMP production.
    Paschke R; Parmentier M; Vassart G
    J Mol Endocrinol; 1994 Oct; 13(2):199-207. PubMed ID: 7848531
    [TBL] [Abstract][Full Text] [Related]  

  • 35. [Peptide 612-627 of thyrotropin receptor and its modified derivatives as the regulators of adenylyl cyclase in the rat thyroid gland].
    Shpakov AO; Shpakova EA; Tarasenko II; Derkach KV
    Tsitologiia; 2014; 56(7):526-35. PubMed ID: 25696997
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Monte Carlo loop refinement and virtual screening of the thyroid-stimulating hormone receptor transmembrane domain.
    Ali MR; Latif R; Davies TF; Mezei M
    J Biomol Struct Dyn; 2015; 33(5):1140-52. PubMed ID: 25012978
    [TBL] [Abstract][Full Text] [Related]  

  • 37. The extracellular domain suppresses constitutive activity of the transmembrane domain of the human TSH receptor: implications for hormone-receptor interaction and antagonist design.
    Zhang M; Tong KP; Fremont V; Chen J; Narayan P; Puett D; Weintraub BD; Szkudlinski MW
    Endocrinology; 2000 Sep; 141(9):3514-7. PubMed ID: 10965926
    [TBL] [Abstract][Full Text] [Related]  

  • 38. The nematode leucine-rich repeat-containing, G protein-coupled receptor (LGR) protein homologous to vertebrate gonadotropin and thyrotropin receptors is constitutively active in mammalian cells.
    Kudo M; Chen T; Nakabayashi K; Hsu SY; Hsueh AJ
    Mol Endocrinol; 2000 Feb; 14(2):272-84. PubMed ID: 10674399
    [TBL] [Abstract][Full Text] [Related]  

  • 39. An inactivating mutation within the first extracellular loop of the thyrotropin receptor impedes normal posttranslational maturation of the extracellular domain.
    Sura-Trueba S; Aumas C; Carre A; Durif S; Leger J; Polak M; de Roux N
    Endocrinology; 2009 Feb; 150(2):1043-50. PubMed ID: 18927215
    [TBL] [Abstract][Full Text] [Related]  

  • 40. A low molecular weight agonist signals by binding to the transmembrane domain of thyroid-stimulating hormone receptor (TSHR) and luteinizing hormone/chorionic gonadotropin receptor (LHCGR).
    Jäschke H; Neumann S; Moore S; Thomas CJ; Colson AO; Costanzi S; Kleinau G; Jiang JK; Paschke R; Raaka BM; Krause G; Gershengorn MC
    J Biol Chem; 2006 Apr; 281(15):9841-4. PubMed ID: 16488885
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 11.