867 related articles for article (PubMed ID: 18389514)
1. Dipeptide derivatives of AZT: synthesis, chemical stability, activation in human plasma, hPEPT1 affinity, and antiviral activity.
Santos C; Morais J; Gouveia L; de Clercq E; Pannecouque C; Nielsen CU; Steffansen B; Moreira R; Gomes P
ChemMedChem; 2008 Jun; 3(6):970-8. PubMed ID: 18389514
[TBL] [Abstract][Full Text] [Related]
2. Interactions of the dipeptide ester prodrugs of acyclovir with the intestinal oligopeptide transporter: competitive inhibition of glycylsarcosine transport in human intestinal cell line-Caco-2.
Anand BS; Patel J; Mitra AK
J Pharmacol Exp Ther; 2003 Feb; 304(2):781-91. PubMed ID: 12538834
[TBL] [Abstract][Full Text] [Related]
3. Structure-activity relationships for dipeptide prodrugs of acyclovir: implications for prodrug design.
Santos CR; Capela R; Pereira CS; Valente E; Gouveia L; Pannecouque C; De Clercq E; Moreira R; Gomes P
Eur J Med Chem; 2009 Jun; 44(6):2339-46. PubMed ID: 18848738
[TBL] [Abstract][Full Text] [Related]
4. Amino acid ester prodrugs of the antiviral agent 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole as potential substrates of hPEPT1 transporter.
Song X; Vig BS; Lorenzi PL; Drach JC; Townsend LB; Amidon GL
J Med Chem; 2005 Feb; 48(4):1274-7. PubMed ID: 15715497
[TBL] [Abstract][Full Text] [Related]
5. Synthesis of methoxypoly(ethylene glycol) carbonate prodrugs of zidovudine and penetration through human skin in vitro.
N'da DD; Breytenbach JC
J Pharm Pharmacol; 2009 Jun; 61(6):721-31. PubMed ID: 19505362
[TBL] [Abstract][Full Text] [Related]
6. Dipeptidomimetic ketomethylene isosteres as pro-moieties for drug transport via the human intestinal di-/tripeptide transporter hPEPT1: design, synthesis, stability, and biological investigations.
Våbenø J; Nielsen CU; Ingebrigtsen T; Lejon T; Steffansen B; Luthman K
J Med Chem; 2004 Sep; 47(19):4755-65. PubMed ID: 15341490
[TBL] [Abstract][Full Text] [Related]
7. Pyrimidine and nucleoside gamma-esters of L-Glu-Sar: synthesis, stability and interaction with hPEPT1.
Eriksson AH; Elm PL; Begtrup M; Brodin B; Nielsen R; Steffansen B
Eur J Pharm Sci; 2005 May; 25(1):145-54. PubMed ID: 15854810
[TBL] [Abstract][Full Text] [Related]
8. Synthesis, in vitro anti-human immunodeficiency virus structure-activity relationships and biological stability of 5'-O-myristoyl analogue derivatives of 3'-azido-2',3'-dideoxythymidine (AZT) as potential prodrugs.
Parang K; Wiebe LI; Knaus EE
Antivir Chem Chemother; 1998 Jul; 9(4):311-23. PubMed ID: 9875410
[TBL] [Abstract][Full Text] [Related]
9. Affinity and translocation relationships via hPEPT1 of H-X aa-Ser-OH dipeptides: evaluation of H-Phe-Ser-OH as a pro-moiety for ibuprofen and benzoic acid prodrugs.
Omkvist DH; Trangbæk DJ; Mildon J; Paine JS; Brodin B; Begtrup M; Nielsen CU
Eur J Pharm Biopharm; 2011 Feb; 77(2):327-31. PubMed ID: 21147219
[TBL] [Abstract][Full Text] [Related]
10. Propylene glycol-linked amino acid/dipeptide diester prodrugs of oleanolic acid for PepT1-mediated transport: synthesis, intestinal permeability, and pharmacokinetics.
Cao F; Gao Y; Wang M; Fang L; Ping Q
Mol Pharm; 2013 Apr; 10(4):1378-87. PubMed ID: 23339520
[TBL] [Abstract][Full Text] [Related]
11. 5'-Amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporter.
Han H; de Vrueh RL; Rhie JK; Covitz KM; Smith PL; Lee CP; Oh DM; Sadée W; Amidon GL
Pharm Res; 1998 Aug; 15(8):1154-9. PubMed ID: 9706043
[TBL] [Abstract][Full Text] [Related]
12. Uncharged AZT and D4T derivatives of phosphonoformic and phosphonoacetic acids as anti-HIV pronucleosides.
Shirokova EA; Jasko MV; Khandazhinskaya AL; Ivanov AV; Yanvarev DV; Skoblov YS; Mitkevich VA; Bocharov EV; Pronyaeva TR; Fedyuk NV; Kukhanova MK; Pokrovsky AG
J Med Chem; 2004 Jul; 47(14):3606-14. PubMed ID: 15214788
[TBL] [Abstract][Full Text] [Related]
13. Cellular uptake mechanism of amino acid ester prodrugs in Caco-2/hPEPT1 cells overexpressing a human peptide transporter.
Han HK; Oh DM; Amidon GL
Pharm Res; 1998 Sep; 15(9):1382-6. PubMed ID: 9755889
[TBL] [Abstract][Full Text] [Related]
14. Novel approaches for designing 5'-O-ester prodrugs of 3'-azido-2', 3'-dideoxythymidine (AZT).
Parang K; Wiebe LI; Knaus EE
Curr Med Chem; 2000 Oct; 7(10):995-1039. PubMed ID: 10911016
[TBL] [Abstract][Full Text] [Related]
15. Synthesis and anti-HIV activity of steroidal prodrugs of 3'-azido-3'-deoxythymidine (AZT).
Balagopala MI; Ollapally AP; Lee HJ
Cell Mol Biol (Noisy-le-grand); 1995; 41 Suppl 1():S1-7. PubMed ID: 8574137
[TBL] [Abstract][Full Text] [Related]
16. Phosphoramidate and phosphate prodrugs of (-)-beta-D-(2R,4R)-dioxolane-thymine: synthesis, anti-HIV activity and stability studies.
Liang Y; Narayanasamy J; Schinazi RF; Chu CK
Bioorg Med Chem; 2006 Apr; 14(7):2178-89. PubMed ID: 16314108
[TBL] [Abstract][Full Text] [Related]
17. cycloSal-Pronucleotides of 2',3'-dideoxyadenosine and 2', 3'-dideoxy-2',3'-didehydroadenosine: synthesis and antiviral evaluation of a highly efficient nucleotide delivery system.
Meier C; Knispel T; De Clercq E; Balzarini J
J Med Chem; 1999 May; 42(9):1604-14. PubMed ID: 10229629
[TBL] [Abstract][Full Text] [Related]
18. Synthesis of zidovudine prodrugs with broad-spectrum chemotherapeutic properties for the effective treatment of HIV/AIDS.
Sriram D; Srichakravarthy N; Bal TR; Yogeeswari P
Biomed Pharmacother; 2005 Sep; 59(8):452-5. PubMed ID: 16154314
[TBL] [Abstract][Full Text] [Related]
19. Design and synthesis of novel SATE derivatives of acyclic isocytosine and 9-deazaadenine C-nucleosides.
Liu LJ; Hong JH
Nucleosides Nucleotides Nucleic Acids; 2010 Mar; 29(3):257-66. PubMed ID: 20408056
[TBL] [Abstract][Full Text] [Related]
20. Synthesis, physicochemical properties and antiviral activities of ester prodrugs of ganciclovir.
Patel K; Trivedi S; Luo S; Zhu X; Pal D; Kern ER; Mitra AK
Int J Pharm; 2005 Nov; 305(1-2):75-89. PubMed ID: 16242278
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
