BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

158 related articles for article (PubMed ID: 18393453)

  • 21. Differences in cytochrome P450-mediated biotransformation of 1,2-dichlorobenzene by rat and man: implications for human risk assessment.
    Hissink AM; Oudshoorn MJ; Van Ommen B; Haenen GR; Van Bladeren PJ
    Chem Res Toxicol; 1996 Dec; 9(8):1249-56. PubMed ID: 8951226
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Application of on-line electrochemical derivatization coupled with high-performance liquid chromatography electrospray ionization mass spectrometry for detection and quantitation of (p-chlorophenyl)aniline in biological samples.
    Chen H; Zhang Y; Mutlib AE; Zhong M
    Anal Chem; 2006 Apr; 78(7):2413-21. PubMed ID: 16579628
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Studies on cytochrome P-450-mediated bioactivation of diclofenac in rats and in human hepatocytes: identification of glutathione conjugated metabolites.
    Tang W; Stearns RA; Bandiera SM; Zhang Y; Raab C; Braun MP; Dean DC; Pang J; Leung KH; Doss GA; Strauss JR; Kwei GY; Rushmore TH; Chiu SH; Baillie TA
    Drug Metab Dispos; 1999 Mar; 27(3):365-72. PubMed ID: 10064567
    [TBL] [Abstract][Full Text] [Related]  

  • 24. A novel bioactivation pathway for 2-[2-(2,6-dichlorophenyl)aminophenyl]ethanoic acid (diclofenac) initiated by cytochrome P450-mediated oxidative decarboxylation.
    Grillo MP; Ma J; Teffera Y; Waldon DJ
    Drug Metab Dispos; 2008 Sep; 36(9):1740-4. PubMed ID: 18541695
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Mechanistic studies on the metabolic scission of thiazolidinedione derivatives to acyclic thiols.
    Reddy VB; Karanam BV; Gruber WL; Wallace MA; Vincent SH; Franklin RB; Baillie TA
    Chem Res Toxicol; 2005 May; 18(5):880-8. PubMed ID: 15892582
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Zafirlukast metabolism by cytochrome P450 3A4 produces an electrophilic alpha,beta-unsaturated iminium species that results in the selective mechanism-based inactivation of the enzyme.
    Kassahun K; Skordos K; McIntosh I; Slaughter D; Doss GA; Baillie TA; Yost GS
    Chem Res Toxicol; 2005 Sep; 18(9):1427-37. PubMed ID: 16167835
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Cytochrome P450-mediated epoxidation of 2-aminothiazole-based AKT inhibitors: identification of novel GSH adducts and reduction of metabolic activation through structural changes guided by in silico and in vitro screening.
    Subramanian R; Lee MR; Allen JG; Bourbeau MP; Fotsch C; Hong FT; Tadesse S; Yao G; Yuan CC; Surapaneni S; Skiles GL; Wang X; Wohlhieter GE; Zeng Q; Zhou Y; Zhu X; Li C
    Chem Res Toxicol; 2010 Mar; 23(3):653-63. PubMed ID: 20095585
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Detection of glutathione conjugates derived from 4-ipomeanol metabolism in bile of rats by liquid chromatography-tandem mass spectrometry.
    Alvarez-Diez TM; Zheng J
    Drug Metab Dispos; 2004 Dec; 32(12):1345-50. PubMed ID: 15328249
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Assessing and minimizing time-dependent inhibition of cytochrome P450 3A in drug discovery: a case study with melanocortin-4 receptor agonists.
    Tang W; Stearns RA; Wang RW; Miller RR; Chen Q; Ngui J; Bakshi RK; Nargund RP; Dean DC; Baillie TA
    Xenobiotica; 2008 Nov; 38(11):1437-51. PubMed ID: 18841517
    [TBL] [Abstract][Full Text] [Related]  

  • 30. In vitro metabolism of N-(5-chloro-2-methylphenyl)-N'-(2-methylpropyl)thiourea: species comparison and identification of a novel thiocarbamide-glutathione adduct.
    Stevens GJ; Hitchcock K; Wang YK; Coppola GM; Versace RW; Chin JA; Shapiro M; Suwanrumpha S; Mangold BL
    Chem Res Toxicol; 1997 Jul; 10(7):733-41. PubMed ID: 9250406
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Metabolic activation of diclofenac by human cytochrome P450 3A4: role of 5-hydroxydiclofenac.
    Shen S; Marchick MR; Davis MR; Doss GA; Pohl LR
    Chem Res Toxicol; 1999 Feb; 12(2):214-22. PubMed ID: 10027801
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Metabolic activation of troglitazone: identification of a reactive metabolite and mechanisms involved.
    He K; Talaat RE; Pool WF; Reily MD; Reed JE; Bridges AJ; Woolf TF
    Drug Metab Dispos; 2004 Jun; 32(6):639-46. PubMed ID: 15155556
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Evidence for the bioactivation of zomepirac and tolmetin by an oxidative pathway: identification of glutathione adducts in vitro in human liver microsomes and in vivo in rats.
    Chen Q; Doss GA; Tung EC; Liu W; Tang YS; Braun MP; Didolkar V; Strauss JR; Wang RW; Stearns RA; Evans DC; Baillie TA; Tang W
    Drug Metab Dispos; 2006 Jan; 34(1):145-51. PubMed ID: 16251255
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Investigation of bioactivation of ticlopidine using linear ion trap/orbitrap mass spectrometry and an improved mass defect filtering technique.
    Ruan Q; Zhu M
    Chem Res Toxicol; 2010 May; 23(5):909-17. PubMed ID: 20297803
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Metabolic activation of the nontricyclic antidepressant trazodone to electrophilic quinone-imine and epoxide intermediates in human liver microsomes and recombinant P4503A4.
    Kalgutkar AS; Henne KR; Lame ME; Vaz AD; Collin C; Soglia JR; Zhao SX; Hop CE
    Chem Biol Interact; 2005 Jun; 155(1-2):10-20. PubMed ID: 15978881
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Species and strain differences in the hepatic cytochrome P450-mediated biotransformation of 1,4-dichlorobenzene.
    Hissink AM; Oudshoorn MJ; Van Ommen B; Van Bladeren PJ
    Toxicol Appl Pharmacol; 1997 Jul; 145(1):1-9. PubMed ID: 9221818
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Metabolic activation of TM5441 in vitro and in vivo: Formation of reactive metabolites and human enzymes involved.
    Lang SQ; Lang WH; Yu HY; Wang L
    Eur J Pharm Sci; 2020 Feb; 143():105195. PubMed ID: 31852629
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Identification in rat bile of glutathione conjugates of fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether, a nephrotoxic degradate of the anesthetic agent sevoflurane.
    Jin L; Davis MR; Kharasch ED; Doss GA; Baillie TA
    Chem Res Toxicol; 1996 Mar; 9(2):555-61. PubMed ID: 8839062
    [TBL] [Abstract][Full Text] [Related]  

  • 39. In vitro metabolism of tolcapone to reactive intermediates: relevance to tolcapone liver toxicity.
    Smith KS; Smith PL; Heady TN; Trugman JM; Harman WD; Macdonald TL
    Chem Res Toxicol; 2003 Feb; 16(2):123-8. PubMed ID: 12588182
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Identification of multi-S-substituted conjugates of hydroquinone by HPLC-coulometric electrode array analysis and mass spectroscopy.
    Hill BA; Kleiner HE; Ryan EA; Dulik DM; Monks TJ; Lau SS
    Chem Res Toxicol; 1993; 6(4):459-69. PubMed ID: 8374043
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 8.