556 related articles for article (PubMed ID: 18393796)
21. Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer's disease.
Andrew RJ; Fernandez CG; Stanley M; Jiang H; Nguyen P; Rice RC; Buggia-Prévot V; De Rossi P; Vetrivel KS; Lamb R; Argemi A; Allaert ES; Rathbun EM; Krause SV; Wagner SL; Parent AT; Holtzman DM; Thinakaran G
Proc Natl Acad Sci U S A; 2017 Nov; 114(45):E9665-E9674. PubMed ID: 29078331
[TBL] [Abstract][Full Text] [Related]
22. Splice variants of the Alzheimer's disease beta-secretase, BACE1.
Holsinger RM; Goense N; Bohorquez J; Strappe P
Neurogenetics; 2013 Feb; 14(1):1-9. PubMed ID: 23142975
[TBL] [Abstract][Full Text] [Related]
23. BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice.
Kim W; Ma L; Lomoio S; Willen R; Lombardo S; Dong J; Haydon PG; Tesco G
Mol Neurodegener; 2018 Feb; 13(1):6. PubMed ID: 29391027
[TBL] [Abstract][Full Text] [Related]
24. The β-Secretase Enzyme BACE1: A Biochemical Enigma for Alzheimer's Disease.
Shah H; Patel A; Parikh V; Nagani A; Bhimani B; Shah U; Bambharoliya T
CNS Neurol Disord Drug Targets; 2020; 19(3):184-194. PubMed ID: 32452328
[TBL] [Abstract][Full Text] [Related]
25. Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes.
Ly PT; Wu Y; Zou H; Wang R; Zhou W; Kinoshita A; Zhang M; Yang Y; Cai F; Woodgett J; Song W
J Clin Invest; 2013 Jan; 123(1):224-35. PubMed ID: 23202730
[TBL] [Abstract][Full Text] [Related]
26. An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease.
Kizuka Y; Kitazume S; Fujinawa R; Saito T; Iwata N; Saido TC; Nakano M; Yamaguchi Y; Hashimoto Y; Staufenbiel M; Hatsuta H; Murayama S; Manya H; Endo T; Taniguchi N
EMBO Mol Med; 2015 Feb; 7(2):175-89. PubMed ID: 25592972
[TBL] [Abstract][Full Text] [Related]
27. The Alzheimer's disease beta-secretase enzyme, BACE1.
Cole SL; Vassar R
Mol Neurodegener; 2007 Nov; 2():22. PubMed ID: 18005427
[TBL] [Abstract][Full Text] [Related]
28. BACE1 SUMOylation increases its stability and escalates the protease activity in Alzheimer's disease.
Bao J; Qin M; Mahaman YAR; Zhang B; Huang F; Zeng K; Xia Y; Ke D; Wang Q; Liu R; Wang JZ; Ye K; Wang X
Proc Natl Acad Sci U S A; 2018 Apr; 115(15):3954-3959. PubMed ID: 29581300
[TBL] [Abstract][Full Text] [Related]
29. Aβ reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level.
Sadleir KR; Eimer WA; Cole SL; Vassar R
Mol Neurodegener; 2015 Jan; 10():1. PubMed ID: 25567526
[TBL] [Abstract][Full Text] [Related]
30. Distinct transcriptional regulation and function of the human BACE2 and BACE1 genes.
Sun X; Wang Y; Qing H; Christensen MA; Liu Y; Zhou W; Tong Y; Xiao C; Huang Y; Zhang S; Liu X; Song W
FASEB J; 2005 May; 19(7):739-49. PubMed ID: 15857888
[TBL] [Abstract][Full Text] [Related]
31. Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease.
Chen CH; Zhou W; Liu S; Deng Y; Cai F; Tone M; Tone Y; Tong Y; Song W
Int J Neuropsychopharmacol; 2012 Feb; 15(1):77-90. PubMed ID: 21329555
[TBL] [Abstract][Full Text] [Related]
32. Reduction of the expression of the late-onset Alzheimer's disease (AD) risk-factor
Andrew RJ; De Rossi P; Nguyen P; Kowalski HR; Recupero AJ; Guerbette T; Krause SV; Rice RC; Laury-Kleintop L; Wagner SL; Thinakaran G
J Biol Chem; 2019 Mar; 294(12):4477-4487. PubMed ID: 30692199
[TBL] [Abstract][Full Text] [Related]
33. A copper-binding site in the cytoplasmic domain of BACE1 identifies a possible link to metal homoeostasis and oxidative stress in Alzheimer's disease.
Dingwall C
Biochem Soc Trans; 2007 Jun; 35(Pt 3):571-3. PubMed ID: 17511654
[TBL] [Abstract][Full Text] [Related]
34. BAG-1M co-activates BACE1 transcription through NF-κB and accelerates Aβ production and memory deficit in Alzheimer's disease mouse model.
Shi Z; Hong Y; Zhang K; Wang J; Zheng L; Zhang Z; Hu Z; Han X; Han Y; Chen T; Yao Q; Cui H; Hong W
Biochim Biophys Acta Mol Basis Dis; 2017 Sep; 1863(9):2398-2407. PubMed ID: 28502705
[TBL] [Abstract][Full Text] [Related]
35. Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models.
Natunen T; Takalo M; Kemppainen S; Leskelä S; Marttinen M; Kurkinen KMA; Pursiheimo JP; Sarajärvi T; Viswanathan J; Gabbouj S; Solje E; Tahvanainen E; Pirttimäki T; Kurki M; Paananen J; Rauramaa T; Miettinen P; Mäkinen P; Leinonen V; Soininen H; Airenne K; Tanzi RE; Tanila H; Haapasalo A; Hiltunen M
Neurobiol Dis; 2016 Jan; 85():187-205. PubMed ID: 26563932
[TBL] [Abstract][Full Text] [Related]
36. The normal and pathologic roles of the Alzheimer's β-secretase, BACE1.
Kandalepas PC; Vassar R
Curr Alzheimer Res; 2014; 11(5):441-9. PubMed ID: 24893886
[TBL] [Abstract][Full Text] [Related]
37. BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild-type mice.
Nishitomi K; Sakaguchi G; Horikoshi Y; Gray AJ; Maeda M; Hirata-Fukae C; Becker AG; Hosono M; Sakaguchi I; Minami SS; Nakajima Y; Li HF; Takeyama C; Kihara T; Ota A; Wong PC; Aisen PS; Kato A; Kinoshita N; Matsuoka Y
J Neurochem; 2006 Dec; 99(6):1555-63. PubMed ID: 17083447
[TBL] [Abstract][Full Text] [Related]
38. The two-hydrophobic domain tertiary structure of reticulon proteins is critical for modulation of beta-secretase BACE1.
Kume H; Murayama KS; Araki W
J Neurosci Res; 2009 Oct; 87(13):2963-72. PubMed ID: 19405102
[TBL] [Abstract][Full Text] [Related]
39. Protective effects of BACE1 inhibitory ligand molecules against amyloid beta-induced synaptic and mitochondrial toxicities in Alzheimer's disease.
Pradeepkiran JA; Reddy AP; Yin X; Manczak M; Reddy PH
Hum Mol Genet; 2020 Jan; 29(1):49-69. PubMed ID: 31595293
[TBL] [Abstract][Full Text] [Related]
40. Camelid heavy chain only antibody fragment domain against β-site of amyloid precursor protein cleaving enzyme 1 inhibits β-secretase activity in vitro and in vivo.
Dorresteijn B; Rotman M; Faber D; Schravesande R; Suidgeest E; van der Weerd L; van der Maarel SM; Verrips CT; El Khattabi M
FEBS J; 2015 Sep; 282(18):3618-31. PubMed ID: 26147692
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]
