165 related articles for article (PubMed ID: 18403248)
1. Role of an invariant lysine residue in folate binding on Escherichia coli thymidylate synthase: calorimetric and crystallographic analysis of the K48Q mutant.
Arvizu-Flores AA; Sugich-Miranda R; Arreola R; Garcia-Orozco KD; Velazquez-Contreras EF; Montfort WR; Maley F; Sotelo-Mundo RR
Int J Biochem Cell Biol; 2008; 40(10):2206-17. PubMed ID: 18403248
[TBL] [Abstract][Full Text] [Related]
2. Crystal structures of thymidylate synthase mutant R166Q: structural basis for the nearly complete loss of catalytic activity.
Sotelo-Mundo RR; Changchien L; Maley F; Montfort WR
J Biochem Mol Toxicol; 2006; 20(2):88-92. PubMed ID: 16615077
[TBL] [Abstract][Full Text] [Related]
3. Binding of the anticancer drug ZD1694 to E. coli thymidylate synthase: assessing specificity and affinity.
Rutenber EE; Stroud RM
Structure; 1996 Nov; 4(11):1317-24. PubMed ID: 8939755
[TBL] [Abstract][Full Text] [Related]
4. Kinetic scheme for thymidylate synthase from Escherichia coli: determination from measurements of ligand binding, primary and secondary isotope effects, and pre-steady-state catalysis.
Spencer HT; Villafranca JE; Appleman JR
Biochemistry; 1997 Apr; 36(14):4212-22. PubMed ID: 9100016
[TBL] [Abstract][Full Text] [Related]
5. Tryptophan 80 and leucine 143 are critical for the hydride transfer step of thymidylate synthase by controlling active site access.
Fritz TA; Liu L; Finer-Moore JS; Stroud RM
Biochemistry; 2002 Jun; 41(22):7021-9. PubMed ID: 12033935
[TBL] [Abstract][Full Text] [Related]
6. Properties of a defined mutant of Escherichia coli thymidylate synthase.
Maley GF; Maley F
J Biol Chem; 1988 Jun; 263(16):7620-7. PubMed ID: 3286637
[TBL] [Abstract][Full Text] [Related]
7. Drug-resistant variants of Escherichia coli thymidylate synthase: effects of substitutions at Pro-254.
Fantz C; Shaw D; Jennings W; Forsthoefel A; Kitchens M; Phan J; Minor W; Lebioda L; Berger FG; Spencer HT
Mol Pharmacol; 2000 Feb; 57(2):359-66. PubMed ID: 10648646
[TBL] [Abstract][Full Text] [Related]
8. Promotion of purine nucleotide binding to thymidylate synthase by a potent folate analogue inhibitor, 1843U89.
Weichsel A; Montfort WR; Cieśla J; Maley F
Proc Natl Acad Sci U S A; 1995 Apr; 92(8):3493-7. PubMed ID: 7724588
[TBL] [Abstract][Full Text] [Related]
9. D221 in thymidylate synthase controls conformation change, and thereby opening of the imidazolidine.
Sage CR; Michelitsch MD; Stout TJ; Biermann D; Nissen R; Finer-Moore J; Stroud RM
Biochemistry; 1998 Sep; 37(39):13893-901. PubMed ID: 9753479
[TBL] [Abstract][Full Text] [Related]
10. The complex of the anti-cancer therapeutic, BW1843U89, with thymidylate synthase at 2.0 A resolution: implications for a new mode of inhibition.
Stout TJ; Stroud RM
Structure; 1996 Jan; 4(1):67-77. PubMed ID: 8805515
[TBL] [Abstract][Full Text] [Related]
11. Role of the conserved tryptophan 82 of Lactobacillus casei thymidylate synthase.
Kealey JT; Eckstein J; Santi DV
Chem Biol; 1995 Sep; 2(9):609-14. PubMed ID: 9383465
[TBL] [Abstract][Full Text] [Related]
12. The separate effects of E60Q in Lactobacillus casei thymidylate synthase delineate between mechanisms for formation of intermediates in catalysis.
Birdsall DL; Huang W; Santi DV; Stroud RM; Finer-Moore J
Protein Eng; 1998 Mar; 11(3):171-83. PubMed ID: 9613841
[TBL] [Abstract][Full Text] [Related]
13. The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261.
Newby Z; Lee TT; Morse RJ; Liu Y; Liu L; Venkatraman P; Santi DV; Finer-Moore JS; Stroud RM
Biochemistry; 2006 Jun; 45(24):7415-28. PubMed ID: 16768437
[TBL] [Abstract][Full Text] [Related]
14. Catalytic cysteine of thymidylate synthase is activated upon substrate binding.
Phan J; Mahdavian E; Nivens MC; Minor W; Berger S; Spencer HT; Dunlap RB; Lebioda L
Biochemistry; 2000 Jun; 39(23):6969-78. PubMed ID: 10841779
[TBL] [Abstract][Full Text] [Related]
15. Entropy in bi-substrate enzymes: proposed role of an alternate site in chaperoning substrate into, and products out of, thymidylate synthase.
Birdsall DL; Finer-Moore J; Stroud RM
J Mol Biol; 1996 Jan; 255(3):522-35. PubMed ID: 8568895
[TBL] [Abstract][Full Text] [Related]
16. Crystal structure of a deletion mutant of human thymidylate synthase Delta (7-29) and its ternary complex with Tomudex and dUMP.
Almog R; Waddling CA; Maley F; Maley GF; Van Roey P
Protein Sci; 2001 May; 10(5):988-96. PubMed ID: 11316879
[TBL] [Abstract][Full Text] [Related]
17. Effect of halogen substitutions on dUMP to stability of thymidylate synthase/dUMP/mTHF ternary complex using molecular dynamics simulation.
Kaiyawet N; Rungrotmongkol T; Hannongbua S
J Chem Inf Model; 2013 Jun; 53(6):1315-23. PubMed ID: 23705822
[TBL] [Abstract][Full Text] [Related]
18. Cofactor triggers the conformational change in thymidylate synthase: implications for an ordered binding mechanism.
Kamb A; Finer-Moore JS; Stroud RM
Biochemistry; 1992 Dec; 31(51):12876-84. PubMed ID: 1281428
[TBL] [Abstract][Full Text] [Related]
19. An essential role for water in an enzyme reaction mechanism: the crystal structure of the thymidylate synthase mutant E58Q.
Sage CR; Rutenber EE; Stout TJ; Stroud RM
Biochemistry; 1996 Dec; 35(50):16270-81. PubMed ID: 8973201
[TBL] [Abstract][Full Text] [Related]
20. Kinetic studies on drug-resistant variants of Escherichia coli thymidylate synthase: functional effects of amino acid substitutions at residue 4.
Mahdavian E; Spencer HT; Dunlap RB
Arch Biochem Biophys; 1999 Aug; 368(2):257-64. PubMed ID: 10441376
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
