These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

175 related articles for article (PubMed ID: 18406216)

  • 1. TREX1 DNA exonuclease deficiency, accumulation of single stranded DNA and complex human genetic disorders.
    O'Driscoll M
    DNA Repair (Amst); 2008 Jun; 7(6):997-1003. PubMed ID: 18406216
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease.
    Yang YG; Lindahl T; Barnes DE
    Cell; 2007 Nov; 131(5):873-86. PubMed ID: 18045533
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The TREX1 exonuclease R114H mutation in Aicardi-Goutières syndrome and lupus reveals dimeric structure requirements for DNA degradation activity.
    Orebaugh CD; Fye JM; Harvey S; Hollis T; Perrino FW
    J Biol Chem; 2011 Nov; 286(46):40246-54. PubMed ID: 21937424
    [TBL] [Abstract][Full Text] [Related]  

  • 4. New roles for the major human 3'-5' exonuclease TREX1 in human disease.
    Kavanagh D; Spitzer D; Kothari PH; Shaikh A; Liszewski MK; Richards A; Atkinson JP
    Cell Cycle; 2008 Jun; 7(12):1718-25. PubMed ID: 18583934
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Biochemical properties of mammalian TREX1 and its association with DNA replication and inherited inflammatory disease.
    Lindahl T; Barnes DE; Yang YG; Robins P
    Biochem Soc Trans; 2009 Jun; 37(Pt 3):535-8. PubMed ID: 19442247
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Aicardi-Goutières syndrome protein TREX1 suppresses L1 and maintains genome integrity through exonuclease-independent ORF1p depletion.
    Li P; Du J; Goodier JL; Hou J; Kang J; Kazazian HH; Zhao K; Yu XF
    Nucleic Acids Res; 2017 May; 45(8):4619-4631. PubMed ID: 28334850
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease.
    Grieves JL; Fye JM; Harvey S; Grayson JM; Hollis T; Perrino FW
    Proc Natl Acad Sci U S A; 2015 Apr; 112(16):5117-22. PubMed ID: 25848017
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Expanding the phenotypic spectrum of lupus erythematosus in Aicardi-Goutières syndrome.
    Ramantani G; Kohlhase J; Hertzberg C; Innes AM; Engel K; Hunger S; Borozdin W; Mah JK; Ungerath K; Walkenhorst H; Richardt HH; Buckard J; Bevot A; Siegel C; von Stülpnagel C; Ikonomidou C; Thomas K; Proud V; Niemann F; Wieczorek D; Häusler M; Niggemann P; Baltaci V; Conrad K; Lebon P; Lee-Kirsch MA
    Arthritis Rheum; 2010 May; 62(5):1469-77. PubMed ID: 20131292
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Defects in DNA degradation revealed in crystal structures of TREX1 exonuclease mutations linked to autoimmune disease.
    Bailey SL; Harvey S; Perrino FW; Hollis T
    DNA Repair (Amst); 2012 Jan; 11(1):65-73. PubMed ID: 22071149
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases.
    Gao D; Li T; Li XD; Chen X; Li QZ; Wight-Carter M; Chen ZJ
    Proc Natl Acad Sci U S A; 2015 Oct; 112(42):E5699-705. PubMed ID: 26371324
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Dominant mutation of the TREX1 exonuclease gene in lupus and Aicardi-Goutieres syndrome.
    Fye JM; Orebaugh CD; Coffin SR; Hollis T; Perrino FW
    J Biol Chem; 2011 Sep; 286(37):32373-82. PubMed ID: 21808053
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Loss of Trex1 in Dendritic Cells Is Sufficient To Trigger Systemic Autoimmunity.
    Peschke K; Achleitner M; Frenzel K; Gerbaulet A; Ada SR; Zeller N; Lienenklaus S; Lesche M; Poulet C; Naumann R; Dahl A; Ravens U; Günther C; Müller W; Knobeloch KP; Prinz M; Roers A; Behrendt R
    J Immunol; 2016 Sep; 197(6):2157-66. PubMed ID: 27511730
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The TREX1 double-stranded DNA degradation activity is defective in dominant mutations associated with autoimmune disease.
    Lehtinen DA; Harvey S; Mulcahy MJ; Hollis T; Perrino FW
    J Biol Chem; 2008 Nov; 283(46):31649-56. PubMed ID: 18805785
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Dysregulation of the immune system in Aicardi-Goutières syndrome: another example in a TREX1-mutated patient.
    Olivieri I; Cattalini M; Tonduti D; La Piana R; Uggetti C; Galli J; Meini A; Tincani A; Moratto D; Fazzi E; Balottin U; Orcesi S
    Lupus; 2013 Sep; 22(10):1064-9. PubMed ID: 23918923
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Trex1 prevents cell-intrinsic initiation of autoimmunity.
    Stetson DB; Ko JS; Heidmann T; Medzhitov R
    Cell; 2008 Aug; 134(4):587-98. PubMed ID: 18724932
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partnering.
    de Silva U; Choudhury S; Bailey SL; Harvey S; Perrino FW; Hollis T
    J Biol Chem; 2007 Apr; 282(14):10537-43. PubMed ID: 17293595
    [TBL] [Abstract][Full Text] [Related]  

  • 17. cGAS activation causes lupus-like autoimmune disorders in a TREX1 mutant mouse model.
    Xiao N; Wei J; Xu S; Du H; Huang M; Zhang S; Ye W; Sun L; Chen Q
    J Autoimmun; 2019 Jun; 100():84-94. PubMed ID: 30872080
    [TBL] [Abstract][Full Text] [Related]  

  • 18. TREX1 As a Potential Therapeutic Target for Autoimmune and Inflammatory Diseases.
    Tao SS; Wu GC; Zhang Q; Zhang TP; Leng RX; Pan HF; Ye DQ
    Curr Pharm Des; 2019; 25(30):3239-3247. PubMed ID: 31475890
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The Arg-62 residues of the TREX1 exonuclease act across the dimer interface contributing to catalysis in the opposing protomers.
    Fye JM; Coffin SR; Orebaugh CD; Hollis T; Perrino FW
    J Biol Chem; 2014 Apr; 289(16):11556-11565. PubMed ID: 24616097
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Measuring TREX1 and TREX2 exonuclease activities.
    Hemphill WO; Perrino FW
    Methods Enzymol; 2019; 625():109-133. PubMed ID: 31455522
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.