124 related articles for article (PubMed ID: 18407491)
21. Neighboring group participation Part 17 Stereoselective synthesis of some steroidal 2-oxazolidones, as novel potential inhibitors of 17alpha-hydroxylase-C(17,20)-lyase.
Ondré D; Wölfling J; Iványi Z; Schneider G; Tóth I; Szécsi M; Julesz J
Steroids; 2008 Dec; 73(14):1375-84. PubMed ID: 18652838
[TBL] [Abstract][Full Text] [Related]
22. Steroselective synthesis of some steroidal oxazolines, as novel potential inhibitors of 17alpha-hydroxylase-C17,20-lyase.
Ondré D; Wölfling J; Tóth I; Szécsi M; Julesz J; Schneider G
Steroids; 2009; 74(13-14):1025-32. PubMed ID: 19666042
[TBL] [Abstract][Full Text] [Related]
23. Molecular cloning and heterologous expression in E. coli of cytochrome P45017alpha. Comparison of structural and functional properties of substrate-specific cytochromes P450 from different species.
Gilep AA; Estabrook RW; Usanov SA
Biochemistry (Mosc); 2003 Jan; 68(1):86-98. PubMed ID: 12693981
[TBL] [Abstract][Full Text] [Related]
24. CYP17 inhibitors. Annulations of additional rings in methylene imidazole substituted biphenyls: synthesis, biological evaluation and molecular modelling.
Pinto-Bazurco Mendieta MA; Negri M; Hu Q; Hille UE; Jagusch C; Jahn-Hoffmann K; Müller-Vieira U; Schmidt D; Lauterbach T; Hartmann RW
Arch Pharm (Weinheim); 2008 Oct; 341(10):597-609. PubMed ID: 18720339
[TBL] [Abstract][Full Text] [Related]
25. Tetrahydronaphthalenes: influence of heterocyclic substituents on inhibition of steroid enzymes P450 arom and P450 17.
Wächter GA; Hartmann RW; Sergejew T; Grün GL; Ledergerber D
J Med Chem; 1996 Feb; 39(4):834-41. PubMed ID: 8632407
[TBL] [Abstract][Full Text] [Related]
26. 17alpha-hydroxylase/17,20-lyase (p450(17alpha)) inhibitors in the treatment of prostate cancer: a review.
Owen CP
Anticancer Agents Med Chem; 2009 Jul; 9(6):613-26. PubMed ID: 19601745
[TBL] [Abstract][Full Text] [Related]
27. Inhibition of p450 17 as a new strategy for the treatment of prostate cancer.
Leroux F
Curr Med Chem; 2005; 12(14):1623-9. PubMed ID: 16022662
[TBL] [Abstract][Full Text] [Related]
28. Some 1-[(benzofuran-2-yl)methyl]imidazoles as inhibitors of 17 alpha-hydroxylase: 17, 20-lyase (P450 17) and their specificity patterns.
Bahshwan SA; Owen CP; Nicholls PJ; Smith HJ; Ahmadi M
J Pharm Pharmacol; 1998 Oct; 50(10):1109-16. PubMed ID: 9821656
[TBL] [Abstract][Full Text] [Related]
29. A new class of nonsteroidal aromatase inhibitors: design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17 alpha-hydroxylase/C17,20-lyase.
Recanatini M; Bisi A; Cavalli A; Belluti F; Gobbi S; Rampa A; Valenti P; Palzer M; Palusczak A; Hartmann RW
J Med Chem; 2001 Mar; 44(5):672-80. PubMed ID: 11262078
[TBL] [Abstract][Full Text] [Related]
30. Inhibition of 17alpha-hydroxylase/C17,20-lyase (CYP17) from rat testis by green tea catechins and black tea theaflavins.
Kimura K; Itakura Y; Goto R; Tojima M; Egawa N; Yoshihama M
Biosci Biotechnol Biochem; 2007 Sep; 71(9):2325-8. PubMed ID: 17827674
[TBL] [Abstract][Full Text] [Related]
31. Synthesis and evaluation of pregnane derivatives as inhibitors of human testicular 17 alpha-hydroxylase/C17,20-lyase.
Li JS; Li Y; Son C; Brodie AM
J Med Chem; 1996 Oct; 39(21):4335-9. PubMed ID: 8863811
[TBL] [Abstract][Full Text] [Related]
32. Differential inhibition of 17alpha-hydroxylase and 17,20-lyase activities by three novel missense CYP17 mutations identified in patients with P450c17 deficiency.
Van Den Akker EL; Koper JW; Boehmer AL; Themmen AP; Verhoef-Post M; Timmerman MA; Otten BJ; Drop SL; De Jong FH
J Clin Endocrinol Metab; 2002 Dec; 87(12):5714-21. PubMed ID: 12466376
[TBL] [Abstract][Full Text] [Related]
33. Novel steroidal pyrimidyl inhibitors of P450 17 (17 alpha-hydroxylase/C17-20-lyase).
Haidar S; Ehmer PB; Hartmann RW
Arch Pharm (Weinheim); 2001 Dec; 334(12):373-4. PubMed ID: 11852531
[No Abstract] [Full Text] [Related]
34. YM116, 2-(1H-imidazol-4-ylmethyl)-9H-carbazole, decreases adrenal androgen synthesis by inhibiting C17-20 lyase activity in NCI-H295 human adrenocortical carcinoma cells.
Ideyama Y; Kudoh M; Tanimoto K; Susaki Y; Nanya T; Nakahara T; Ishikawa H; Fujikura T; Akaza H; Shikama H
Jpn J Pharmacol; 1999 Feb; 79(2):213-20. PubMed ID: 10202857
[TBL] [Abstract][Full Text] [Related]
35. C16 and C17 substituted derivatives of pregnenolone and progesterone as inhibitors of 17alpha-hydroxylase-C17, 20-lyase: synthesis and biological evaluation.
Haidar S; Hartmann RW
Arch Pharm (Weinheim); 2002; 335(11-12):526-34. PubMed ID: 12596217
[TBL] [Abstract][Full Text] [Related]
36. P450c17 mutations R347H and R358Q selectively disrupt 17,20-lyase activity by disrupting interactions with P450 oxidoreductase and cytochrome b5.
Geller DH; Auchus RJ; Miller WL
Mol Endocrinol; 1999 Jan; 13(1):167-75. PubMed ID: 9892022
[TBL] [Abstract][Full Text] [Related]
37. Novel P450(17alpha) inhibitors: 17-(2'-oxazolyl)- and 17-(2'-thiazolyl)-androstene derivatives.
Zhu N; Ling Y; Lei X; Handratta V; Brodie AM
Steroids; 2003 Sep; 68(7-8):603-11. PubMed ID: 12957665
[TBL] [Abstract][Full Text] [Related]
38. The 16,17-double bond is needed for irreversible inhibition of human cytochrome p45017alpha by abiraterone (17-(3-pyridyl)androsta-5, 16-dien-3beta-ol) and related steroidal inhibitors.
Jarman M; Barrie SE; Llera JM
J Med Chem; 1998 Dec; 41(27):5375-81. PubMed ID: 9876107
[TBL] [Abstract][Full Text] [Related]
39. Molecular modeling of human P450c17 (17alpha-hydroxylase/17,20-lyase): insights into reaction mechanisms and effects of mutations.
Auchus RJ; Miller WL
Mol Endocrinol; 1999 Jul; 13(7):1169-82. PubMed ID: 10406467
[TBL] [Abstract][Full Text] [Related]
40. Design, synthesis, and biological evaluation of imidazolyl derivatives of 4,7-disubstituted coumarins as aromatase inhibitors selective over 17-α-hydroxylase/C17-20 lyase.
Stefanachi A; Favia AD; Nicolotti O; Leonetti F; Pisani L; Catto M; Zimmer C; Hartmann RW; Carotti A
J Med Chem; 2011 Mar; 54(6):1613-25. PubMed ID: 21341743
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]
