BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

96 related articles for article (PubMed ID: 18413256)

  • 1. Biochemical and biological characterization of tumor-associated mutations of p110alpha.
    Denley A; Gymnopoulos M; Hart JR; Jiang H; Zhao L; Vogt PK
    Methods Enzymol; 2008; 438():291-305. PubMed ID: 18413256
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase.
    Avruch J; Hara K; Lin Y; Liu M; Long X; Ortiz-Vega S; Yonezawa K
    Oncogene; 2006 Oct; 25(48):6361-72. PubMed ID: 17041622
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Rheb activation of mTOR and S6K1 signaling.
    Hanrahan J; Blenis J
    Methods Enzymol; 2006; 407():542-55. PubMed ID: 16757352
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression.
    Fingar DC; Blenis J
    Oncogene; 2004 Apr; 23(18):3151-71. PubMed ID: 15094765
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Rheb promotes cell growth as a component of the insulin/TOR signalling network.
    Saucedo LJ; Gao X; Chiarelli DA; Li L; Pan D; Edgar BA
    Nat Cell Biol; 2003 Jun; 5(6):566-71. PubMed ID: 12766776
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Mutations in the catalytic subunit of class IA PI3K confer leukemogenic potential to hematopoietic cells.
    Horn S; Bergholz U; Jücker M; McCubrey JA; Trümper L; Stocking C; Bäsecke J
    Oncogene; 2008 Jul; 27(29):4096-106. PubMed ID: 18317450
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Novel role of the small GTPase Rheb: its implication in endocytic pathway independent of the activation of mammalian target of rapamycin.
    Saito K; Araki Y; Kontani K; Nishina H; Katada T
    J Biochem; 2005 Mar; 137(3):423-30. PubMed ID: 15809346
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Reduction in the requirement of oncogenic Ras signaling to activation of PI3K/AKT pathway during tumor maintenance.
    Lim KH; Counter CM
    Cancer Cell; 2005 Nov; 8(5):381-92. PubMed ID: 16286246
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Phosphoinositide 3-kinase: from viral oncoprotein to drug target.
    Vogt PK; Bader AG; Kang S
    Virology; 2006 Jan; 344(1):131-8. PubMed ID: 16364744
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Selective inhibition of growth of tuberous sclerosis complex 2 null cells by atorvastatin is associated with impaired Rheb and Rho GTPase function and reduced mTOR/S6 kinase activity.
    Finlay GA; Malhowski AJ; Liu Y; Fanburg BL; Kwiatkowski DJ; Toksoz D
    Cancer Res; 2007 Oct; 67(20):9878-86. PubMed ID: 17942919
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Rheb is an essential regulator of S6K in controlling cell growth in Drosophila.
    Stocker H; Radimerski T; Schindelholz B; Wittwer F; Belawat P; Daram P; Breuer S; Thomas G; Hafen E
    Nat Cell Biol; 2003 Jun; 5(6):559-65. PubMed ID: 12766775
    [TBL] [Abstract][Full Text] [Related]  

  • 12. NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations.
    Serra V; Markman B; Scaltriti M; Eichhorn PJ; Valero V; Guzman M; Botero ML; Llonch E; Atzori F; Di Cosimo S; Maira M; Garcia-Echeverria C; Parra JL; Arribas J; Baselga J
    Cancer Res; 2008 Oct; 68(19):8022-30. PubMed ID: 18829560
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Increased Rheb-TOR signaling enhances sensitivity of the whole organism to oxidative stress.
    Patel PH; Tamanoi F
    J Cell Sci; 2006 Oct; 119(Pt 20):4285-92. PubMed ID: 17038544
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Functional inhibition of PI3K by the betaGBP molecule suppresses Ras-MAPK signalling to block cell proliferation.
    Wells V; Downward J; Mallucci L
    Oncogene; 2007 Dec; 26(55):7709-14. PubMed ID: 17603562
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Cancer-specific mutations in phosphatidylinositol 3-kinase.
    Vogt PK; Kang S; Elsliger MA; Gymnopoulos M
    Trends Biochem Sci; 2007 Jul; 32(7):342-9. PubMed ID: 17561399
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Constitutively active Rheb induces oncogenic transformation.
    Jiang H; Vogt PK
    Oncogene; 2008 Sep; 27(43):5729-40. PubMed ID: 18521078
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Regulation of class IA PI3Ks: is there a role for monomeric PI3K subunits?
    Geering B; Cutillas PR; Vanhaesebroeck B
    Biochem Soc Trans; 2007 Apr; 35(Pt 2):199-203. PubMed ID: 17371237
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Oncogenic Ras, but not (V600E)B-RAF, protects from cholesterol depletion-induced apoptosis through the PI3K/AKT pathway in colorectal cancer cells.
    Calleros L; Sánchez-Hernández I; Baquero P; Toro MJ; Chiloeches A
    Carcinogenesis; 2009 Oct; 30(10):1670-7. PubMed ID: 19700418
    [TBL] [Abstract][Full Text] [Related]  

  • 19. PI3 kinases in cancer: from oncogene artifact to leading cancer target.
    Zhao JJ; Roberts TM
    Sci STKE; 2006 Dec; 2006(365):pe52. PubMed ID: 17164467
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Regulation of the small GTPase Rheb by amino acids.
    Roccio M; Bos JL; Zwartkruis FJ
    Oncogene; 2006 Feb; 25(5):657-64. PubMed ID: 16170341
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 5.