BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

399 related articles for article (PubMed ID: 18420139)

  • 1. An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase.
    Deacon SW; Beeser A; Fukui JA; Rennefahrt UE; Myers C; Chernoff J; Peterson JR
    Chem Biol; 2008 Apr; 15(4):322-31. PubMed ID: 18420139
    [TBL] [Abstract][Full Text] [Related]  

  • 2. An allosteric kinase inhibitor binds the p21-activated kinase autoregulatory domain covalently.
    Viaud J; Peterson JR
    Mol Cancer Ther; 2009 Sep; 8(9):2559-65. PubMed ID: 19723886
    [TBL] [Abstract][Full Text] [Related]  

  • 3. PAK'n it in: identification of a selective PAK inhibitor.
    Bokoch GM
    Chem Biol; 2008 Apr; 15(4):305-6. PubMed ID: 18420134
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Small molecules that allosterically inhibit p21-activated kinase activity by binding to the regulatory p21-binding domain.
    Kim DJ; Choi CK; Lee CS; Park MH; Tian X; Kim ND; Lee KI; Choi JK; Ahn JH; Shin EY; Shin I; Kim EG
    Exp Mol Med; 2016 Apr; 48(4):e229. PubMed ID: 27126178
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Targeting p21-activated kinase 1 inhibits growth and metastasis via Raf1/MEK1/ERK signaling in esophageal squamous cell carcinoma cells.
    Chen L; Bi S; Hou J; Zhao Z; Wang C; Xie S
    Cell Commun Signal; 2019 Apr; 17(1):31. PubMed ID: 30971268
    [TBL] [Abstract][Full Text] [Related]  

  • 6. p21-activated kinase inhibitors.
    Rudolph J; Crawford JJ; Hoeflich KP; Chernoff J
    Enzymes; 2013; 34 Pt. B():157-80. PubMed ID: 25034104
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Inhibitors of p21-activated kinases (PAKs).
    Rudolph J; Crawford JJ; Hoeflich KP; Wang W
    J Med Chem; 2015 Jan; 58(1):111-29. PubMed ID: 25415869
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Group I PAK inhibitor IPA-3 induces cell death and affects cell adhesivity to fibronectin in human hematopoietic cells.
    Kuželová K; Grebeňová D; Holoubek A; Röselová P; Obr A
    PLoS One; 2014; 9(3):e92560. PubMed ID: 24664099
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Inhibition of p21-Activated Kinase 1 by IPA-3 Promotes Locomotor Recovery After Spinal Cord Injury in Mice.
    Ji X; Zhang Y; Zhang L; Chen H; Peng Y; Tang P
    Spine (Phila Pa 1976); 2016 Jun; 41(11):919-925. PubMed ID: 26863260
    [TBL] [Abstract][Full Text] [Related]  

  • 10. FRAX597, a small molecule inhibitor of the p21-activated kinases, inhibits tumorigenesis of neurofibromatosis type 2 (NF2)-associated Schwannomas.
    Licciulli S; Maksimoska J; Zhou C; Troutman S; Kota S; Liu Q; Duron S; Campbell D; Chernoff J; Field J; Marmorstein R; Kissil JL
    J Biol Chem; 2013 Oct; 288(40):29105-14. PubMed ID: 23960073
    [TBL] [Abstract][Full Text] [Related]  

  • 11. IPA-3 inhibits the growth of liver cancer cells by suppressing PAK1 and NF-κB activation.
    Wong LL; Lam IP; Wong TY; Lai WL; Liu HF; Yeung LL; Ching YP
    PLoS One; 2013; 8(7):e68843. PubMed ID: 23894351
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Thymoquinone-induced conformational changes of PAK1 interrupt prosurvival MEK-ERK signaling in colorectal cancer.
    El-Baba C; Mahadevan V; Fahlbusch FB; Mohan S S; Rau TT; Gali-Muhtasib H; Schneider-Stock R
    Mol Cancer; 2014 Aug; 13():201. PubMed ID: 25174975
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Targeting Phosphorylation of p21-activated Kinase 1 at Thr423 Induces Cell Cycle Arrest and Apoptosis in Cutaneous T-cell Lymphoma Cells.
    Wang Y; Li W; Zhang Q; Gu X; He X; Men Y; Zhang C
    Acta Derm Venereol; 2019 Oct; 99(11):1022-1028. PubMed ID: 31304555
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Inhibition of p21-activated kinase 1 by IPA-3 attenuates secondary injury after traumatic brain injury in mice.
    Ji X; Zhang W; Zhang L; Zhang L; Zhang Y; Tang P
    Brain Res; 2014 Oct; 1585():13-22. PubMed ID: 25148711
    [TBL] [Abstract][Full Text] [Related]  

  • 15. p21-activated kinase 1 activity is required for histone H3 Ser
    Zhang N; Li X; Liu X; Cao Y; Chen D; Liu X; Wang Q; Du J; Weng J; Ma W
    Reprod Fertil Dev; 2017 Jul; 29(7):1287-1296. PubMed ID: 27166635
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Effect of P21-activated kinase 1 (PAK-1) inhibition on cancer cell growth, migration, and invasion.
    Najahi-Missaoui W; Quach ND; Jenkins A; Dabke I; Somanath PR; Cummings BS
    Pharmacol Res Perspect; 2019 Oct; 7(5):e00518. PubMed ID: 31516713
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Inhibition of p21 activated kinase (PAK) reduces airway responsiveness in vivo and in vitro in murine and human airways.
    Hoover WC; Zhang W; Xue Z; Gao H; Chernoff J; Clapp DW; Gunst SJ; Tepper RS
    PLoS One; 2012; 7(8):e42601. PubMed ID: 22900031
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Anti-cancer effect of novel PAK1 inhibitor via induction of PUMA-mediated cell death and p21-mediated cell cycle arrest.
    Woo TG; Yoon MH; Hong SD; Choi J; Ha NC; Sun H; Park BJ
    Oncotarget; 2017 Apr; 8(14):23690-23701. PubMed ID: 28423593
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Toxicity and anti-angiogenicity evaluation of Pak1 inhibitor IPA-3 using zebrafish embryo model.
    Jagadeeshan S; Sagayaraj RV; Paneerselvan N; Ghouse SS; Malathi R
    Cell Biol Toxicol; 2017 Feb; 33(1):41-56. PubMed ID: 27581547
    [TBL] [Abstract][Full Text] [Related]  

  • 20. P21 activated kinase-1 mediates transforming growth factor β1-induced prostate cancer cell epithelial to mesenchymal transition.
    Al-Azayzih A; Gao F; Somanath PR
    Biochim Biophys Acta; 2015 May; 1853(5):1229-39. PubMed ID: 25746720
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 20.