These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

163 related articles for article (PubMed ID: 18421145)

  • 1. Fragment approaches in structure-based drug discovery.
    Hubbard RE
    J Synchrotron Radiat; 2008 May; 15(Pt 3):227-30. PubMed ID: 18421145
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Novel isoquinolone PDK1 inhibitors discovered through fragment-based lead discovery.
    Johnson MC; Hu Q; Lingardo L; Ferre RA; Greasley S; Yan J; Kath J; Chen P; Ermolieff J; Alton G
    J Comput Aided Mol Des; 2011 Jul; 25(7):689-98. PubMed ID: 21779981
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Fragment-based drug discovery applied to Hsp90. Discovery of two lead series with high ligand efficiency.
    Murray CW; Carr MG; Callaghan O; Chessari G; Congreve M; Cowan S; Coyle JE; Downham R; Figueroa E; Frederickson M; Graham B; McMenamin R; O'Brien MA; Patel S; Phillips TR; Williams G; Woodhead AJ; Woolford AJ
    J Med Chem; 2010 Aug; 53(16):5942-55. PubMed ID: 20718493
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Optimal strategies for virtual screening of induced-fit and flexible target in the 2015 D3R Grand Challenge.
    Ye Z; Baumgartner MP; Wingert BM; Camacho CJ
    J Comput Aided Mol Des; 2016 Sep; 30(9):695-706. PubMed ID: 27573981
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The SeeDs approach: integrating fragments into drug discovery.
    Hubbard RE; Davis B; Chen I; Drysdale MJ
    Curr Top Med Chem; 2007; 7(16):1568-81. PubMed ID: 17979768
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Fragment-based lead discovery to identify novel inhibitors that target the ATP binding site of pyruvate dehydrogenase kinases.
    Akaki T; Bessho Y; Ito T; Fujioka S; Ubukata M; Mori G; Yamanaka K; Orita T; Doi S; Iwanaga T; Ikegashira K; Hantani Y; Nakanishi I; Adachi T
    Bioorg Med Chem; 2021 Aug; 44():116283. PubMed ID: 34274549
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Improved pose and affinity predictions using different protocols tailored on the basis of data availability.
    Prathipati P; Nagao C; Ahmad S; Mizuguchi K
    J Comput Aided Mol Des; 2016 Sep; 30(9):817-828. PubMed ID: 27714493
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Prospective evaluation of shape similarity based pose prediction method in D3R Grand Challenge 2015.
    Kumar A; Zhang KY
    J Comput Aided Mol Des; 2016 Sep; 30(9):685-693. PubMed ID: 27484214
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Establish an automated flow injection ESI-MS method for the screening of fragment based libraries: Application to Hsp90.
    Riccardi Sirtori F; Caronni D; Colombo M; Dalvit C; Paolucci M; Regazzoni L; Visco C; Fogliatto G
    Eur J Pharm Sci; 2015 Aug; 76():83-94. PubMed ID: 25952103
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Fragment-based screening by protein crystallography: successes and pitfalls.
    Chilingaryan Z; Yin Z; Oakley AJ
    Int J Mol Sci; 2012 Oct; 13(10):12857-79. PubMed ID: 23202926
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Hsp90 inhibitors and drugs from fragment and virtual screening.
    Roughley S; Wright L; Brough P; Massey A; Hubbard RE
    Top Curr Chem; 2012; 317():61-82. PubMed ID: 21647838
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Improving binding mode and binding affinity predictions of docking by ligand-based search of protein conformations: evaluation in D3R grand challenge 2015.
    Xu X; Yan C; Zou X
    J Comput Aided Mol Des; 2017 Aug; 31(8):689-699. PubMed ID: 28668990
    [TBL] [Abstract][Full Text] [Related]  

  • 13. In silico fragment-based drug discovery: setup and validation of a fragment-to-lead computational protocol using S4MPLE.
    Hoffer L; Renaud JP; Horvath D
    J Chem Inf Model; 2013 Apr; 53(4):836-51. PubMed ID: 23537132
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Fragment-based hit discovery and structure-based optimization of aminotriazoloquinazolines as novel Hsp90 inhibitors.
    Casale E; Amboldi N; Brasca MG; Caronni D; Colombo N; Dalvit C; Felder ER; Fogliatto G; Galvani A; Isacchi A; Polucci P; Riceputi L; Sola F; Visco C; Zuccotto F; Casuscelli F
    Bioorg Med Chem; 2014 Aug; 22(15):4135-50. PubMed ID: 24980703
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Discovery and design of novel HSP90 inhibitors using multiple fragment-based design strategies.
    Huth JR; Park C; Petros AM; Kunzer AR; Wendt MD; Wang X; Lynch CL; Mack JC; Swift KM; Judge RA; Chen J; Richardson PL; Jin S; Tahir SK; Matayoshi ED; Dorwin SA; Ladror US; Severin JM; Walter KA; Bartley DM; Fesik SW; Elmore SW; Hajduk PJ
    Chem Biol Drug Des; 2007 Jul; 70(1):1-12. PubMed ID: 17630989
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Selection of fragments for kinase inhibitor design: decoration is key.
    Czodrowski P; Hölzemann G; Barnickel G; Greiner H; Musil D
    J Med Chem; 2015 Jan; 58(1):457-65. PubMed ID: 25437144
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Experiences in fragment-based drug discovery.
    Murray CW; Verdonk ML; Rees DC
    Trends Pharmacol Sci; 2012 May; 33(5):224-32. PubMed ID: 22459076
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Development of Computational Approaches with a Fragment-Based Drug Design Strategy: In Silico Hsp90 Inhibitors Discovery.
    León R; Soto-Delgado J; Montero E; Vargas M
    Int J Mol Sci; 2021 Dec; 22(24):. PubMed ID: 34948022
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Fragment-based approaches to the discovery of kinase inhibitors.
    Mortenson PN; Berdini V; O'Reilly M
    Methods Enzymol; 2014; 548():69-92. PubMed ID: 25399642
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery.
    Erlanson DA; Arndt JW; Cancilla MT; Cao K; Elling RA; English N; Friedman J; Hansen SK; Hession C; Joseph I; Kumaravel G; Lee WC; Lind KE; McDowell RS; Miatkowski K; Nguyen C; Nguyen TB; Park S; Pathan N; Penny DM; Romanowski MJ; Scott D; Silvian L; Simmons RL; Tangonan BT; Yang W; Sun L
    Bioorg Med Chem Lett; 2011 May; 21(10):3078-83. PubMed ID: 21459573
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.