163 related articles for article (PubMed ID: 18421157)
1. Structural insights into the similar modes of Nrf2 transcription factor recognition by the cytoplasmic repressor Keap1.
Padmanabhan B; Tong KI; Kobayashi A; Yamamoto M; Yokoyama S
J Synchrotron Radiat; 2008 May; 15(Pt 3):273-6. PubMed ID: 18421157
[TBL] [Abstract][Full Text] [Related]
2. Structural analysis of the complex of Keap1 with a prothymosin alpha peptide.
Padmanabhan B; Nakamura Y; Yokoyama S
Acta Crystallogr Sect F Struct Biol Cryst Commun; 2008 Apr; 64(Pt 4):233-8. PubMed ID: 18391415
[TBL] [Abstract][Full Text] [Related]
3. Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model.
Tong KI; Katoh Y; Kusunoki H; Itoh K; Tanaka T; Yamamoto M
Mol Cell Biol; 2006 Apr; 26(8):2887-900. PubMed ID: 16581765
[TBL] [Abstract][Full Text] [Related]
4. Different electrostatic potentials define ETGE and DLG motifs as hinge and latch in oxidative stress response.
Tong KI; Padmanabhan B; Kobayashi A; Shang C; Hirotsu Y; Yokoyama S; Yamamoto M
Mol Cell Biol; 2007 Nov; 27(21):7511-21. PubMed ID: 17785452
[TBL] [Abstract][Full Text] [Related]
5. Structural insights into the multiple binding modes of Dimethyl Fumarate (DMF) and its analogs to the Kelch domain of Keap1.
Unni S; Deshmukh P; Krishnappa G; Kommu P; Padmanabhan B
FEBS J; 2021 Mar; 288(5):1599-1613. PubMed ID: 32672401
[TBL] [Abstract][Full Text] [Related]
6. Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex.
McMahon M; Thomas N; Itoh K; Yamamoto M; Hayes JD
J Biol Chem; 2006 Aug; 281(34):24756-68. PubMed ID: 16790436
[TBL] [Abstract][Full Text] [Related]
7. Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome.
Katoh Y; Iida K; Kang MI; Kobayashi A; Mizukami M; Tong KI; McMahon M; Hayes JD; Itoh K; Yamamoto M
Arch Biochem Biophys; 2005 Jan; 433(2):342-50. PubMed ID: 15581590
[TBL] [Abstract][Full Text] [Related]
8. Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains.
Ogura T; Tong KI; Mio K; Maruyama Y; Kurokawa H; Sato C; Yamamoto M
Proc Natl Acad Sci U S A; 2010 Feb; 107(7):2842-7. PubMed ID: 20133743
[TBL] [Abstract][Full Text] [Related]
9. Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer.
Padmanabhan B; Tong KI; Ohta T; Nakamura Y; Scharlock M; Ohtsuji M; Kang MI; Kobayashi A; Yokoyama S; Yamamoto M
Mol Cell; 2006 Mar; 21(5):689-700. PubMed ID: 16507366
[TBL] [Abstract][Full Text] [Related]
10. Kelch-like ECH-associated protein 1 (KEAP1) differentially regulates nuclear factor erythroid-2-related factors 1 and 2 (NRF1 and NRF2).
Tian W; Rojo de la Vega M; Schmidlin CJ; Ooi A; Zhang DD
J Biol Chem; 2018 Feb; 293(6):2029-2040. PubMed ID: 29255090
[TBL] [Abstract][Full Text] [Related]
11. Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex.
Baird L; Llères D; Swift S; Dinkova-Kostova AT
Proc Natl Acad Sci U S A; 2013 Sep; 110(38):15259-64. PubMed ID: 23986495
[TBL] [Abstract][Full Text] [Related]
12. ¹H, ¹⁵N and ¹³C backbone resonance assignments of the Kelch domain of mouse Keap1.
Cino E; Fan J; Yang D; Choy WY
Biomol NMR Assign; 2013 Oct; 7(2):149-53. PubMed ID: 22688683
[TBL] [Abstract][Full Text] [Related]
13. p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription.
Jain A; Lamark T; Sjøttem E; Larsen KB; Awuh JA; Øvervatn A; McMahon M; Hayes JD; Johansen T
J Biol Chem; 2010 Jul; 285(29):22576-91. PubMed ID: 20452972
[TBL] [Abstract][Full Text] [Related]
14. Negative regulation of the Nrf1 transcription factor by its N-terminal domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulum.
Zhang Y; Crouch DH; Yamamoto M; Hayes JD
Biochem J; 2006 Nov; 399(3):373-85. PubMed ID: 16872277
[TBL] [Abstract][Full Text] [Related]
15. Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes.
Kang MI; Kobayashi A; Wakabayashi N; Kim SG; Yamamoto M
Proc Natl Acad Sci U S A; 2004 Feb; 101(7):2046-51. PubMed ID: 14764898
[TBL] [Abstract][Full Text] [Related]
16. Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron.
McMahon M; Thomas N; Itoh K; Yamamoto M; Hayes JD
J Biol Chem; 2004 Jul; 279(30):31556-67. PubMed ID: 15143058
[TBL] [Abstract][Full Text] [Related]
17. Purification, crystallization and preliminary X-ray diffraction analysis of the Kelch-like motif region of mouse Keap1.
Padmanabhan B; Scharlock M; Tong KI; Nakamura Y; Kang MI; Kobayashi A; Matsumoto T; Tanaka A; Yamamoto M; Yokoyama S
Acta Crystallogr Sect F Struct Biol Cryst Commun; 2005 Jan; 61(Pt 1):153-5. PubMed ID: 16508120
[TBL] [Abstract][Full Text] [Related]
18. Kinetic, thermodynamic, and structural characterizations of the association between Nrf2-DLGex degron and Keap1.
Fukutomi T; Takagi K; Mizushima T; Ohuchi N; Yamamoto M
Mol Cell Biol; 2014 Mar; 34(5):832-46. PubMed ID: 24366543
[TBL] [Abstract][Full Text] [Related]
19. Peptide inhibitors of the Keap1-Nrf2 protein-protein interaction.
Hancock R; Bertrand HC; Tsujita T; Naz S; El-Bakry A; Laoruchupong J; Hayes JD; Wells G
Free Radic Biol Med; 2012 Jan; 52(2):444-51. PubMed ID: 22107959
[TBL] [Abstract][Full Text] [Related]
20. Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling.
Lo SC; Li X; Henzl MT; Beamer LJ; Hannink M
EMBO J; 2006 Aug; 25(15):3605-17. PubMed ID: 16888629
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]