BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

206 related articles for article (PubMed ID: 18439432)

  • 1. Studies with leucine, beta-hydroxybutyrate and ATP citrate lyase-deficient beta cells support the acetoacetate pathway of insulin secretion.
    Macdonald MJ; Hasan NM; Longacre MJ
    Biochim Biophys Acta; 2008; 1780(7-8):966-72. PubMed ID: 18439432
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Feasibility of pathways for transfer of acyl groups from mitochondria to the cytosol to form short chain acyl-CoAs in the pancreatic beta cell.
    MacDonald MJ; Smith AD; Hasan NM; Sabat G; Fahien LA
    J Biol Chem; 2007 Oct; 282(42):30596-606. PubMed ID: 17724028
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Acetoacetate and beta-hydroxybutyrate in combination with other metabolites release insulin from INS-1 cells and provide clues about pathways in insulin secretion.
    MacDonald MJ; Longacre MJ; Stoker SW; Brown LJ; Hasan NM; Kendrick MA
    Am J Physiol Cell Physiol; 2008 Feb; 294(2):C442-50. PubMed ID: 18160486
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Differences between human and rodent pancreatic islets: low pyruvate carboxylase, atp citrate lyase, and pyruvate carboxylation and high glucose-stimulated acetoacetate in human pancreatic islets.
    MacDonald MJ; Longacre MJ; Stoker SW; Kendrick M; Thonpho A; Brown LJ; Hasan NM; Jitrapakdee S; Fukao T; Hanson MS; Fernandez LA; Odorico J
    J Biol Chem; 2011 May; 286(21):18383-96. PubMed ID: 21454710
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Knockdown of ATP citrate lyase in pancreatic beta cells does not inhibit insulin secretion or glucose flux and implicates the acetoacetate pathway in insulin secretion.
    El Azzouny M; Longacre MJ; Ansari IH; Kennedy RT; Burant CF; MacDonald MJ
    Mol Metab; 2016 Oct; 5(10):980-987. PubMed ID: 27689010
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Acute metabolic amplification of insulin secretion in mouse islets is mediated by mitochondrial export of metabolites, but not by mitochondrial energy generation.
    Panten U; Willenborg M; Schumacher K; Hamada A; Ghaly H; Rustenbeck I
    Metabolism; 2013 Oct; 62(10):1375-86. PubMed ID: 23790612
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Activation of the KATP channel-independent signaling pathway by the nonhydrolyzable analog of leucine, BCH.
    Liu YJ; Cheng H; Drought H; MacDonald MJ; Sharp GW; Straub SG
    Am J Physiol Endocrinol Metab; 2003 Aug; 285(2):E380-9. PubMed ID: 12709398
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Insulin secretion profiles are modified by overexpression of glutamate dehydrogenase in pancreatic islets.
    Carobbio S; Ishihara H; Fernandez-Pascual S; Bartley C; Martin-Del-Rio R; Maechler P
    Diabetologia; 2004 Feb; 47(2):266-76. PubMed ID: 14689183
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Anaplerosis from glucose, alpha-ketoisocaproate, and pyruvate in pancreatic islets, INS-1 cells and liver mitochondria.
    MacDonald MJ; Stoker SW; Hasan NM
    Mol Cell Biochem; 2008 Jun; 313(1-2):195-202. PubMed ID: 18414997
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Lower succinyl-CoA:3-ketoacid-CoA transferase (SCOT) and ATP citrate lyase in pancreatic islets of a rat model of type 2 diabetes: knockdown of SCOT inhibits insulin release in rat insulinoma cells.
    Hasan NM; Longacre MJ; Seed Ahmed M; Kendrick MA; Gu H; Ostenson CG; Fukao T; MacDonald MJ
    Arch Biochem Biophys; 2010 Jul; 499(1-2):62-8. PubMed ID: 20460097
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Glucose regulation of glutaminolysis and its role in insulin secretion.
    Gao ZY; Li G; Najafi H; Wolf BA; Matschinsky FM
    Diabetes; 1999 Aug; 48(8):1535-42. PubMed ID: 10426370
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Synergistic potent insulin release by combinations of weak secretagogues in pancreatic islets and INS-1 cells.
    MacDonald MJ
    J Biol Chem; 2007 Mar; 282(9):6043-52. PubMed ID: 17210580
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Differential sensitivity to beta-cell secretagogues in cultured rat pancreatic islets exposed to human interleukin-1 beta.
    Eizirik DL; Sandler S; Hallberg A; Bendtzen K; Sener A; Malaisse WJ
    Endocrinology; 1989 Aug; 125(2):752-9. PubMed ID: 2666106
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The stimulus-secretion coupling of amino acid-induced insulin release. XII. Contrasting effects of L-leucine and a nonmetabolized analog upon islet metabolism and insulin secretion.
    Sener A; Malaisse-Lagae F; Malaisse WJ
    Horm Metab Res; 1982 Sep; 14(9):459-63. PubMed ID: 6128292
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Decreased pancreatic islet response to L-leucine in the spontaneously diabetic GK rat: enzymatic, metabolic and secretory data.
    Giroix MH; Saulnier C; Portha B
    Diabetologia; 1999 Aug; 42(8):965-77. PubMed ID: 10491757
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Glucose regulates leucine-induced insulin release and the expression of the branched chain ketoacid dehydrogenase E1 alpha subunit gene in pancreatic islets.
    MacDonald MJ; McKenzie DI; Kaysen JH; Walker TM; Moran SM; Fahien LA; Towle HC
    J Biol Chem; 1991 Jan; 266(2):1335-40. PubMed ID: 1985951
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Glutaminolysis and insulin secretion: from bedside to bench and back.
    Kelly A; Li C; Gao Z; Stanley CA; Matschinsky FM
    Diabetes; 2002 Dec; 51 Suppl 3():S421-6. PubMed ID: 12475785
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The stimulus-secretion coupling of amino acid-induced insulin release. Metabolic response of pancreatic islets of L-glutamine and L-leucine.
    Malaisse WJ; Sener A; Malaisse-Lagae F; Welsh M; Matthews DE; Bier DM; Hellerström C
    J Biol Chem; 1982 Aug; 257(15):8731-7. PubMed ID: 7047526
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Regulation of glucose- and mitochondrial fuel-induced insulin secretion by a cytosolic protein histidine phosphatase in pancreatic beta-cells.
    Kamath V; Kyathanahalli CN; Jayaram B; Syed I; Olson LK; Ludwig K; Klumpp S; Krieglstein J; Kowluru A
    Am J Physiol Endocrinol Metab; 2010 Aug; 299(2):E276-86. PubMed ID: 20501872
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Stimulation of pancreatic islet metabolism and insulin release by a nonmetabolizable amino acid.
    Sener A; Malaisse-Lagae F; Malaisse WJ
    Proc Natl Acad Sci U S A; 1981 Sep; 78(9):5460-4. PubMed ID: 6117857
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.