BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

209 related articles for article (PubMed ID: 18442981)

  • 1. Tubocapsenolide A, a novel withanolide, inhibits proliferation and induces apoptosis in MDA-MB-231 cells by thiol oxidation of heat shock proteins.
    Chen WY; Chang FR; Huang ZY; Chen JH; Wu YC; Wu CC
    J Biol Chem; 2008 Jun; 283(25):17184-93. PubMed ID: 18442981
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Withanolides-induced breast cancer cell death is correlated with their ability to inhibit heat protein 90.
    Wang HC; Tsai YL; Wu YC; Chang FR; Liu MH; Chen WY; Wu CC
    PLoS One; 2012; 7(5):e37764. PubMed ID: 22701533
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Dual targeting of HSC70 and HSP72 inhibits HSP90 function and induces tumor-specific apoptosis.
    Powers MV; Clarke PA; Workman P
    Cancer Cell; 2008 Sep; 14(3):250-62. PubMed ID: 18772114
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells.
    Massey AJ; Williamson DS; Browne H; Murray JB; Dokurno P; Shaw T; Macias AT; Daniels Z; Geoffroy S; Dopson M; Lavan P; Matassova N; Francis GL; Graham CJ; Parsons R; Wang Y; Padfield A; Comer M; Drysdale MJ; Wood M
    Cancer Chemother Pharmacol; 2010 Aug; 66(3):535-45. PubMed ID: 20012863
    [TBL] [Abstract][Full Text] [Related]  

  • 5. CAIR-1/BAG-3 abrogates heat shock protein-70 chaperone complex-mediated protein degradation: accumulation of poly-ubiquitinated Hsp90 client proteins.
    Doong H; Rizzo K; Fang S; Kulpa V; Weissman AM; Kohn EC
    J Biol Chem; 2003 Aug; 278(31):28490-500. PubMed ID: 12750378
    [TBL] [Abstract][Full Text] [Related]  

  • 6. X-linked inhibitor of apoptosis protein (XIAP) is a client of heat shock protein 70 (Hsp70) and a biomarker of its inhibition.
    Cesa LC; Shao H; Srinivasan SR; Tse E; Jain C; Zuiderweg ERP; Southworth DR; Mapp AK; Gestwicki JE
    J Biol Chem; 2018 Feb; 293(7):2370-2380. PubMed ID: 29255093
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Y-632 inhibits heat shock protein 90 (Hsp90) function by disrupting the interaction between Hsp90 and Hsp70/Hsp90 organizing protein, and exerts antitumor activity in vitro and in vivo.
    Wang W; Liu Y; Zhao Z; Xie C; Xu Y; Hu Y; Quan H; Lou L
    Cancer Sci; 2016 Jun; 107(6):782-90. PubMed ID: 27002306
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structure-activity relationship (SAR) of withanolides to inhibit Hsp90 for its activity in pancreatic cancer cells.
    Gu M; Yu Y; Gunaherath GM; Gunatilaka AA; Li D; Sun D
    Invest New Drugs; 2014 Feb; 32(1):68-74. PubMed ID: 23887853
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Tubocapsenolide A targets C-terminal cysteine residues of HSP90 to exert the anti-tumor effect.
    Zhu D; Li S; Chen C; Wang S; Zhu J; Kong L; Luo J
    Pharmacol Res; 2021 Apr; 166():105523. PubMed ID: 33667688
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Withaferin A targets heat shock protein 90 in pancreatic cancer cells.
    Yu Y; Hamza A; Zhang T; Gu M; Zou P; Newman B; Li Y; Gunatilaka AA; Zhan CG; Sun D
    Biochem Pharmacol; 2010 Feb; 79(4):542-51. PubMed ID: 19769945
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Oxidative inhibition of Hsp90 disrupts the super-chaperone complex and attenuates pancreatic adenocarcinoma in vitro and in vivo.
    Sarkar S; Dutta D; Samanta SK; Bhattacharya K; Pal BC; Li J; Datta K; Mandal C; Mandal C
    Int J Cancer; 2013 Feb; 132(3):695-706. PubMed ID: 22729780
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Death by chaperone: HSP90, HSP70 or both?
    Powers MV; Clarke PA; Workman P
    Cell Cycle; 2009 Feb; 8(4):518-26. PubMed ID: 19197160
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Effects of HIV protease inhibitor ritonavir on Akt-regulated cell proliferation in breast cancer.
    Srirangam A; Mitra R; Wang M; Gorski JC; Badve S; Baldridge L; Hamilton J; Kishimoto H; Hawes J; Li L; Orschell CM; Srour EF; Blum JS; Donner D; Sledge GW; Nakshatri H; Potter DA
    Clin Cancer Res; 2006 Mar; 12(6):1883-96. PubMed ID: 16551874
    [TBL] [Abstract][Full Text] [Related]  

  • 14. C0818, a novel curcumin derivative, induces ROS-dependent cytotoxicity in human hepatocellular carcinoma cells in vitro via disruption of Hsp90 function.
    Abdelmoaty AAA; Zhang P; Lin W; Fan YJ; Ye SN; Xu JH
    Acta Pharmacol Sin; 2022 Feb; 43(2):446-456. PubMed ID: 33824458
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Inhibition of heat shock protein 90 function by 17-allylamino-17-demethoxy-geldanamycin in Hodgkin's lymphoma cells down-regulates Akt kinase, dephosphorylates extracellular signal-regulated kinase, and induces cell cycle arrest and cell death.
    Georgakis GV; Li Y; Rassidakis GZ; Martinez-Valdez H; Medeiros LJ; Younes A
    Clin Cancer Res; 2006 Jan; 12(2):584-90. PubMed ID: 16428504
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The flavonoid TL-2-8 induces cell death and immature mitophagy in breast cancer cells via abrogating the function of the AHA1/Hsp90 complex.
    Liu HJ; Jiang XX; Guo YZ; Sun FH; Kou XH; Bao Y; Zhang ZQ; Lin ZH; Ding TB; Jiang L; Lei XS; Yang YH
    Acta Pharmacol Sin; 2017 Oct; 38(10):1381-1393. PubMed ID: 28504248
    [TBL] [Abstract][Full Text] [Related]  

  • 17. C-terminal phosphorylation of Hsp70 and Hsp90 regulates alternate binding to co-chaperones CHIP and HOP to determine cellular protein folding/degradation balances.
    Muller P; Ruckova E; Halada P; Coates PJ; Hrstka R; Lane DP; Vojtesek B
    Oncogene; 2013 Jun; 32(25):3101-10. PubMed ID: 22824801
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Both the N- and C-terminal chaperone sites of Hsp90 participate in protein refolding.
    Minami M; Nakamura M; Emori Y; Minami Y
    Eur J Biochem; 2001 Apr; 268(8):2520-4. PubMed ID: 11298772
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Anticancer activity of methylene blue via inhibition of heat shock protein 70.
    Sanchala D; Bhatt LK; Pethe P; Shelat R; Kulkarni YA
    Biomed Pharmacother; 2018 Nov; 107():1037-1045. PubMed ID: 30257315
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Valproic acid inhibits proliferation of HER2-expressing breast cancer cells by inducing cell cycle arrest and apoptosis through Hsp70 acetylation.
    Mawatari T; Ninomiya I; Inokuchi M; Harada S; Hayashi H; Oyama K; Makino I; Nakagawara H; Miyashita T; Tajima H; Takamura H; Fushida S; Ohta T
    Int J Oncol; 2015 Dec; 47(6):2073-81. PubMed ID: 26497673
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.