BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

210 related articles for article (PubMed ID: 18448432)

  • 1. Identification of a new motif required for the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I (Klenow fragment): the RRRY motif is necessary for the binding of single-stranded DNA substrate and the template strand of the mismatched duplex.
    Kukreti P; Singh K; Ketkar A; Modak MJ
    J Biol Chem; 2008 Jun; 283(26):17979-90. PubMed ID: 18448432
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Contribution of polar residues of the J-helix in the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I (Klenow fragment): Q677 regulates the removal of terminal mismatch.
    Singh K; Modak MJ
    Biochemistry; 2005 Jun; 44(22):8101-10. PubMed ID: 15924429
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Primer-terminus stabilization at the 3'-5' exonuclease active site of phi29 DNA polymerase. Involvement of two amino acid residues highly conserved in proofreading DNA polymerases.
    de Vega M; Lazaro JM; Salas M; Blanco L
    EMBO J; 1996 Mar; 15(5):1182-92. PubMed ID: 8605889
    [TBL] [Abstract][Full Text] [Related]  

  • 4. 3'-5' exonuclease of Klenow fragment: role of amino acid residues within the single-stranded DNA binding region in exonucleolysis and duplex DNA melting.
    Lam WC; Thompson EH; Potapova O; Sun XC; Joyce CM; Millar DP
    Biochemistry; 2002 Mar; 41(12):3943-51. PubMed ID: 11900537
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Interaction of Escherichia coli DNA polymerase I with azidoDNA and fluorescent DNA probes: identification of protein-DNA contacts.
    Catalano CE; Allen DJ; Benkovic SJ
    Biochemistry; 1990 Apr; 29(15):3612-21. PubMed ID: 2187527
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Presence of 18-A long hydrogen bond track in the active site of Escherichia coli DNA polymerase I (Klenow fragment). Its requirement in the stabilization of enzyme-template-primer complex.
    Singh K; Modak MJ
    J Biol Chem; 2003 Mar; 278(13):11289-302. PubMed ID: 12522214
    [TBL] [Abstract][Full Text] [Related]  

  • 7. DNA substrate structural requirements for the exonuclease and polymerase activities of procaryotic and phage DNA polymerases.
    Cowart M; Gibson KJ; Allen DJ; Benkovic SJ
    Biochemistry; 1989 Mar; 28(5):1975-83. PubMed ID: 2541768
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Determinants of DNA mismatch recognition within the polymerase domain of the Klenow fragment.
    Thompson EH; Bailey MF; van der Schans EJ; Joyce CM; Millar DP
    Biochemistry; 2002 Jan; 41(3):713-22. PubMed ID: 11790092
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Recognition of sequence-directed DNA structure by the Klenow fragment of DNA polymerase I.
    Carver TE; Millar DP
    Biochemistry; 1998 Feb; 37(7):1898-904. PubMed ID: 9485315
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Functional consequences and exonuclease kinetic parameters of point mutations in bacteriophage T4 DNA polymerase.
    Abdus Sattar AK; Lin TC; Jones C; Konigsberg WH
    Biochemistry; 1996 Dec; 35(51):16621-9. PubMed ID: 8987997
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Local conformations and competitive binding affinities of single- and double-stranded primer-template DNA at the polymerization and editing active sites of DNA polymerases.
    Datta K; Johnson NP; LiCata VJ; von Hippel PH
    J Biol Chem; 2009 Jun; 284(25):17180-17193. PubMed ID: 19411253
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Effects of mutations on the partitioning of DNA substrates between the polymerase and 3'-5' exonuclease sites of DNA polymerase I (Klenow fragment).
    Lam WC; Van der Schans EJ; Joyce CM; Millar DP
    Biochemistry; 1998 Feb; 37(6):1513-22. PubMed ID: 9484221
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structure of DNA polymerase I Klenow fragment bound to duplex DNA.
    Beese LS; Derbyshire V; Steitz TA
    Science; 1993 Apr; 260(5106):352-5. PubMed ID: 8469987
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Phage phi 29 DNA polymerase residues involved in the proper stabilisation of the primer-terminus at the 3'-5' exonuclease active site.
    de Vega M; Lázaro JM; Salas M
    J Mol Biol; 2000 Nov; 304(1):1-9. PubMed ID: 11071805
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Exonuclease-polymerase active site partitioning of primer-template DNA strands and equilibrium Mg2+ binding properties of bacteriophage T4 DNA polymerase.
    Beechem JM; Otto MR; Bloom LB; Eritja R; Reha-Krantz LJ; Goodman MF
    Biochemistry; 1998 Jul; 37(28):10144-55. PubMed ID: 9665720
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Mutations in the spacer region of Drosophila mitochondrial DNA polymerase affect DNA binding, processivity, and the balance between Pol and Exo function.
    Luo N; Kaguni LS
    J Biol Chem; 2005 Jan; 280(4):2491-7. PubMed ID: 15537632
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Functional importance of bacteriophage phi29 DNA polymerase residue Tyr148 in primer-terminus stabilisation at the 3'-5' exonuclease active site.
    Pérez-Arnaiz P; Lázaro JM; Salas M; de Vega M
    J Mol Biol; 2009 Sep; 391(5):797-807. PubMed ID: 19576228
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Dimerization of the Klenow fragment of Escherichia coli DNA polymerase I is linked to its mode of DNA binding.
    Bailey MF; Van der Schans EJ; Millar DP
    Biochemistry; 2007 Jul; 46(27):8085-99. PubMed ID: 17567151
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Site-directed mutagenesis at the Exo III motif of phi 29 DNA polymerase; overlapping structural domains for the 3'-5' exonuclease and strand-displacement activities.
    Soengas MS; Esteban JA; Lázaro JM; Bernad A; Blasco MA; Salas M; Blanco L
    EMBO J; 1992 Nov; 11(11):4227-37. PubMed ID: 1396603
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structure of an open conformation of T7 DNA polymerase reveals novel structural features regulating primer-template stabilization at the polymerization active site.
    Juarez-Quintero V; Peralta-Castro A; Benítez Cardoza CG; Ellenberger T; Brieba LG
    Biochem J; 2021 Jul; 478(13):2665-2679. PubMed ID: 34160020
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.