294 related articles for article (PubMed ID: 18454168)
21. A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning.
Shirey JK; Brady AE; Jones PJ; Davis AA; Bridges TM; Kennedy JP; Jadhav SB; Menon UN; Xiang Z; Watson ML; Christian EP; Doherty JJ; Quirk MC; Snyder DH; Lah JJ; Levey AI; Nicolle MM; Lindsley CW; Conn PJ
J Neurosci; 2009 Nov; 29(45):14271-86. PubMed ID: 19906975
[TBL] [Abstract][Full Text] [Related]
22. FRET-based detection of M1 muscarinic acetylcholine receptor activation by orthosteric and allosteric agonists.
Markovic D; Holdich J; Al-Sabah S; Mistry R; Krasel C; Mahaut-Smith MP; Challiss RA
PLoS One; 2012; 7(1):e29946. PubMed ID: 22272263
[TBL] [Abstract][Full Text] [Related]
23. Further exploration of M₁ allosteric agonists: subtle structural changes abolish M₁ allosteric agonism and result in pan-mAChR orthosteric antagonism.
Sheffler DJ; Sevel C; Le U; Lovell KM; Tarr JC; Carrington SJ; Cho HP; Digby GJ; Niswender CM; Conn PJ; Hopkins CR; Wood MR; Lindsley CW
Bioorg Med Chem Lett; 2013 Jan; 23(1):223-7. PubMed ID: 23200253
[TBL] [Abstract][Full Text] [Related]
24. Using cholinergic M1 receptor positive allosteric modulators to improve memory via enhancement of brain cholinergic communication.
Chambon C; Jatzke C; Wegener N; Gravius A; Danysz W
Eur J Pharmacol; 2012 Dec; 697(1-3):73-80. PubMed ID: 23085025
[TBL] [Abstract][Full Text] [Related]
25. Structural Features of Iperoxo-BQCA Muscarinic Acetylcholine Receptor Hybrid Ligands Determining Subtype Selectivity and Efficacy.
Wakeham MCL; Davie BJ; Chalmers DK; Christopoulos A; Capuano B; Valant C; Scammells PJ
ACS Chem Neurosci; 2022 Jan; 13(1):97-111. PubMed ID: 34905693
[TBL] [Abstract][Full Text] [Related]
26. Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity.
Marlo JE; Niswender CM; Days EL; Bridges TM; Xiang Y; Rodriguez AL; Shirey JK; Brady AE; Nalywajko T; Luo Q; Austin CA; Williams MB; Kim K; Williams R; Orton D; Brown HA; Lindsley CW; Weaver CD; Conn PJ
Mol Pharmacol; 2009 Mar; 75(3):577-88. PubMed ID: 19047481
[TBL] [Abstract][Full Text] [Related]
27. Probing the binding site of novel selective positive allosteric modulators at the M
Khajehali E; Valant C; Jörg M; Tobin AB; Conn PJ; Lindsley CW; Sexton PM; Scammells PJ; Christopoulos A
Biochem Pharmacol; 2018 Aug; 154():243-254. PubMed ID: 29777683
[TBL] [Abstract][Full Text] [Related]
28. Identification and pharmacological profile of SPP1, a potent, functionally selective and brain penetrant agonist at muscarinic M
Broad LM; Sanger HE; Mogg AJ; Colvin EM; Zwart R; Evans DA; Pasqui F; Sher E; Wishart GN; Barth VN; Felder CC; Goldsmith PJ
Br J Pharmacol; 2019 Jan; 176(1):110-126. PubMed ID: 30276808
[TBL] [Abstract][Full Text] [Related]
29. Evidence for Classical Cholinergic Toxicity Associated with Selective Activation of M1 Muscarinic Receptors.
Alt A; Pendri A; Bertekap RL; Li G; Benitex Y; Nophsker M; Rockwell KL; Burford NT; Sum CS; Chen J; Herbst JJ; Ferrante M; Hendricson A; Cvijic ME; Westphal RS; O'Connell J; Banks M; Zhang L; Gentles RG; Jenkins S; Loy J; Macor JE
J Pharmacol Exp Ther; 2016 Feb; 356(2):293-304. PubMed ID: 26582730
[TBL] [Abstract][Full Text] [Related]
30. On the unique binding and activating properties of xanomeline at the M1 muscarinic acetylcholine receptor.
Christopoulos A; Pierce TL; Sorman JL; El-Fakahany EE
Mol Pharmacol; 1998 Jun; 53(6):1120-30. PubMed ID: 9614217
[TBL] [Abstract][Full Text] [Related]
31. Biased Profile of Xanomeline at the Recombinant Human M
McDonald JK; van der Westhuizen ET; Pham V; Thompson G; Felder CC; Paul SM; Thal DM; Christopoulos A; Valant C
ACS Chem Neurosci; 2022 Apr; 13(8):1206-1218. PubMed ID: 35380782
[TBL] [Abstract][Full Text] [Related]
32. Muscarinic agonist, (±)-quinuclidin-3-yl-(4-fluorophenethyl)(phenyl)carbamate: High affinity, but low subtype selectivity for human M
Lee NR; Gujarathi S; Bommagani S; Siripurapu K; Zheng G; Dwoskin LP
Bioorg Med Chem Lett; 2019 Feb; 29(3):471-476. PubMed ID: 30554957
[TBL] [Abstract][Full Text] [Related]
33. Striatal, Hippocampal, and Cortical Networks Are Differentially Responsive to the M4- and M1-Muscarinic Acetylcholine Receptor Mediated Effects of Xanomeline.
Thorn CA; Moon J; Bourbonais CA; Harms J; Edgerton JR; Stark E; Steyn SJ; Butter CR; Lazzaro JT; O'Connor RE; Popiolek M
ACS Chem Neurosci; 2019 Mar; 10(3):1753-1764. PubMed ID: 30480428
[TBL] [Abstract][Full Text] [Related]
34. Synthesis and pharmacological evaluation of dimeric muscarinic acetylcholine receptor agonists.
Christopoulos A; Grant MK; Ayoubzadeh N; Kim ON; Sauerberg P; Jeppesen L; El-Fakahany EE
J Pharmacol Exp Ther; 2001 Sep; 298(3):1260-8. PubMed ID: 11504829
[TBL] [Abstract][Full Text] [Related]
35. Broad analgesic activity of a novel, selective M1 agonist.
Wood MW; Martino G; Coupal M; Lindberg M; Schroeder P; Santhakumar V; Valiquette M; Sandin J; Widzowski D; Laird J
Neuropharmacology; 2017 Sep; 123():233-241. PubMed ID: 28623171
[TBL] [Abstract][Full Text] [Related]
36. Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models.
Digby GJ; Noetzel MJ; Bubser M; Utley TJ; Walker AG; Byun NE; Lebois EP; Xiang Z; Sheffler DJ; Cho HP; Davis AA; Nemirovsky NE; Mennenga SE; Camp BW; Bimonte-Nelson HA; Bode J; Italiano K; Morrison R; Daniels JS; Niswender CM; Olive MF; Lindsley CW; Jones CK; Conn PJ
J Neurosci; 2012 Jun; 32(25):8532-44. PubMed ID: 22723693
[TBL] [Abstract][Full Text] [Related]
37. Discovery and structure-activity relationships study of positive allosteric modulators of the M
Tanaka H; Negoro K; Koike T; Tsukamoto I; Yokoyama K; Maeda J; Inagaki Y; Shimoshige Y; Ino K; Ishizu K; Takahashi T
Bioorg Med Chem; 2020 Jul; 28(13):115531. PubMed ID: 32386953
[TBL] [Abstract][Full Text] [Related]
38. Regulation of muscarinic receptor expression by changes in mRNA stability.
Fraser CM; Lee NH
Life Sci; 1995; 56(11-12):899-906. PubMed ID: 10188791
[TBL] [Abstract][Full Text] [Related]
39. Characterization of a Novel M1 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator Radioligand, [3H]PT-1284.
Smith DL; Davoren JE; Edgerton JR; Lazzaro JT; Lee CW; Neal S; Zhang L; Grimwood S
Mol Pharmacol; 2016 Sep; 90(3):177-87. PubMed ID: 27382013
[TBL] [Abstract][Full Text] [Related]
40. 1-[3-(4-Butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77-LH-28-1) as a Model for the Rational Design of a Novel Class of Brain Penetrant Ligands with High Affinity and Selectivity for Dopamine D
Del Bello F; Bonifazi A; Giorgioni G; Cifani C; Micioni Di Bonaventura MV; Petrelli R; Piergentili A; Fontana S; Mammoli V; Yano H; Matucci R; Vistoli G; Quaglia W
J Med Chem; 2018 Apr; 61(8):3712-3725. PubMed ID: 29589445
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]
