213 related articles for article (PubMed ID: 18458130)
1. Chemical target validation studies of aminopeptidase in malaria parasites using alpha-aminoalkylphosphonate and phosphonopeptide inhibitors.
Cunningham E; Drag M; Kafarski P; Bell A
Antimicrob Agents Chemother; 2008 Sep; 52(9):3221-8. PubMed ID: 18458130
[TBL] [Abstract][Full Text] [Related]
2. Aminopeptidases of malaria parasites: new targets for chemotherapy.
Trenholme KR; Brown CL; Skinner-Adams TS; Stack C; Lowther J; To J; Robinson MW; Donnelly SM; Dalton JP; Gardiner DL
Infect Disord Drug Targets; 2010 Jun; 10(3):217-25. PubMed ID: 20334618
[TBL] [Abstract][Full Text] [Related]
3. Overexpression of leucyl aminopeptidase in Plasmodium falciparum parasites. Target for the antimalarial activity of bestatin.
Gardiner DL; Trenholme KR; Skinner-Adams TS; Stack CM; Dalton JP
J Biol Chem; 2006 Jan; 281(3):1741-5. PubMed ID: 16286469
[TBL] [Abstract][Full Text] [Related]
4. Selective inhibition of PfA-M1, over PfA-M17, by an amino-benzosuberone derivative blocks malaria parasites development in vitro and in vivo.
Bounaadja L; Schmitt M; Albrecht S; Mouray E; Tarnus C; Florent I
Malar J; 2017 Sep; 16(1):382. PubMed ID: 28934959
[TBL] [Abstract][Full Text] [Related]
5. Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions.
Drinkwater N; Vinh NB; Mistry SN; Bamert RS; Ruggeri C; Holleran JP; Loganathan S; Paiardini A; Charman SA; Powell AK; Avery VM; McGowan S; Scammells PJ
Eur J Med Chem; 2016 Mar; 110():43-64. PubMed ID: 26807544
[TBL] [Abstract][Full Text] [Related]
6. Genetic and chemical validation of
Edgar RCS; Siddiqui G; Hjerrild K; Malcolm TR; Vinh NB; Webb CT; Holmes C; MacRaild CA; Chernih HC; Suen WW; Counihan NA; Creek DJ; Scammells PJ; McGowan S; de Koning-Ward TF
Elife; 2022 Sep; 11():. PubMed ID: 36097817
[TBL] [Abstract][Full Text] [Related]
7. Screening and In Vitro Evaluation of Potential Plasmodium falciparum Leucyl Aminopeptidase Inhibitors.
Chaudhary M; Singh V; Anvikar AR; Sahi S
Curr Comput Aided Drug Des; 2016; 12(4):282-293. PubMed ID: 27449897
[TBL] [Abstract][Full Text] [Related]
8. Modelling of human leucyl aminopeptidases for in silico off target binding analysis of potential Plasmodium falciparum leucine aminopeptidase (PfA-M17) specific inhibitors.
Sahi S; Raj U; Chaudhary M; Nain V
Recent Pat Endocr Metab Immune Drug Discov; 2014; 8(3):191-201. PubMed ID: 25269653
[TBL] [Abstract][Full Text] [Related]
9. Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases.
Harbut MB; Velmourougane G; Dalal S; Reiss G; Whisstock JC; Onder O; Brisson D; McGowan S; Klemba M; Greenbaum DC
Proc Natl Acad Sci U S A; 2011 Aug; 108(34):E526-34. PubMed ID: 21844374
[TBL] [Abstract][Full Text] [Related]
10. Plasmodium falciparum neutral aminopeptidases: new targets for anti-malarials.
Skinner-Adams TS; Stack CM; Trenholme KR; Brown CL; Grembecka J; Lowther J; Mucha A; Drag M; Kafarski P; McGowan S; Whisstock JC; Gardiner DL; Dalton JP
Trends Biochem Sci; 2010 Jan; 35(1):53-61. PubMed ID: 19796954
[TBL] [Abstract][Full Text] [Related]
11. Biochemical and cellular characterisation of the Plasmodium falciparum M1 alanyl aminopeptidase (PfM1AAP) and M17 leucyl aminopeptidase (PfM17LAP).
Mathew R; Wunderlich J; Thivierge K; Cwiklinski K; Dumont C; Tilley L; Rohrbach P; Dalton JP
Sci Rep; 2021 Feb; 11(1):2854. PubMed ID: 33536500
[TBL] [Abstract][Full Text] [Related]
12. Mapping the substrate specificity of the Plasmodium M1 and M17 aminopeptidases.
Malcolm TR; Swiderska KW; Hayes BK; Webb CT; Drag M; Drinkwater N; McGowan S
Biochem J; 2021 Jul; 478(13):2697-2713. PubMed ID: 34133730
[TBL] [Abstract][Full Text] [Related]
13. Identification of Potent and Selective Inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PfM18AAP) of Human Malaria via High-Throughput Screening.
Spicer T; Fernandez-Vega V; Chase P; Scampavia L; To J; Dalton JP; Da Silva FL; Skinner-Adams TS; Gardiner DL; Trenholme KR; Brown CL; Ghosh P; Porubsky P; Wang JL; Whipple DA; Schoenen FJ; Hodder P
J Biomol Screen; 2014 Aug; 19(7):1107-15. PubMed ID: 24619116
[TBL] [Abstract][Full Text] [Related]
14. Parasite Metalo-aminopeptidases as Targets in Human Infectious Diseases.
Aguado ME; Izquierdo M; González-Matos M; Varela AC; Méndez Y; Del Rivero MA; Rivera DG; González-Bacerio J
Curr Drug Targets; 2023; 24(5):416-461. PubMed ID: 36825701
[TBL] [Abstract][Full Text] [Related]
15. Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases.
McGowan S; Oellig CA; Birru WA; Caradoc-Davies TT; Stack CM; Lowther J; Skinner-Adams T; Mucha A; Kafarski P; Grembecka J; Trenholme KR; Buckle AM; Gardiner DL; Dalton JP; Whisstock JC
Proc Natl Acad Sci U S A; 2010 Feb; 107(6):2449-54. PubMed ID: 20133789
[TBL] [Abstract][Full Text] [Related]
16. Two-pronged attack: dual inhibition of Plasmodium falciparum M1 and M17 metalloaminopeptidases by a novel series of hydroxamic acid-based inhibitors.
Mistry SN; Drinkwater N; Ruggeri C; Sivaraman KK; Loganathan S; Fletcher S; Drag M; Paiardini A; Avery VM; Scammells PJ; McGowan S
J Med Chem; 2014 Nov; 57(21):9168-83. PubMed ID: 25299353
[TBL] [Abstract][Full Text] [Related]
17. Identification and Validation of a Potent Dual Inhibitor of the P. falciparum M1 and M17 Aminopeptidases Using Virtual Screening.
Ruggeri C; Drinkwater N; Sivaraman KK; Bamert RS; McGowan S; Paiardini A
PLoS One; 2015; 10(9):e0138957. PubMed ID: 26406322
[TBL] [Abstract][Full Text] [Related]
18. Characterization of the Plasmodium falciparum M17 leucyl aminopeptidase. A protease involved in amino acid regulation with potential for antimalarial drug development.
Stack CM; Lowther J; Cunningham E; Donnelly S; Gardiner DL; Trenholme KR; Skinner-Adams TS; Teuscher F; Grembecka J; Mucha A; Kafarski P; Lua L; Bell A; Dalton JP
J Biol Chem; 2007 Jan; 282(3):2069-80. PubMed ID: 17107951
[TBL] [Abstract][Full Text] [Related]
19. Roles for two aminopeptidases in vacuolar hemoglobin catabolism in Plasmodium falciparum.
Dalal S; Klemba M
J Biol Chem; 2007 Dec; 282(49):35978-87. PubMed ID: 17895246
[TBL] [Abstract][Full Text] [Related]
20. The aminopeptidase inhibitor CHR-2863 is an orally bioavailable inhibitor of murine malaria.
Skinner-Adams TS; Peatey CL; Anderson K; Trenholme KR; Krige D; Brown CL; Stack C; Nsangou DM; Mathews RT; Thivierge K; Dalton JP; Gardiner DL
Antimicrob Agents Chemother; 2012 Jun; 56(6):3244-9. PubMed ID: 22450967
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
