BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

212 related articles for article (PubMed ID: 18459168)

  • 1. Structure, physiological role, and specific inhibitors of human thymidine kinase 2 (TK2): present and future.
    Pérez-Pérez MJ; Priego EM; Hernández AI; Familiar O; Camarasa MJ; Negri A; Gago F; Balzarini J
    Med Res Rev; 2008 Sep; 28(5):797-820. PubMed ID: 18459168
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Recent advances in thymidine kinase 2 (TK2) inhibitors and new perspectives for potential applications.
    Priego EM; Karlsson A; Gago F; Camarasa MJ; Balzarini J; Pérez-Pérez MJ
    Curr Pharm Des; 2012; 18(20):2981-94. PubMed ID: 22571666
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Mitochondrial thymidine kinase inhibitors.
    Pérez-Pérez MJ; Hernández AI; Priego EM; Rodríguez-Barrios F; Gago F; Camarasa MJ; Balzarini J
    Curr Top Med Chem; 2005; 5(13):1205-19. PubMed ID: 16305527
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The kinetic effects on thymidine kinase 2 by enzyme-bound dTTP may explain the mitochondrial side effects of antiviral thymidine analogs.
    Wang L; Sun R; Eriksson S
    Antimicrob Agents Chemother; 2011 Jun; 55(6):2552-8. PubMed ID: 21444706
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Zidovudine induces downregulation of mitochondrial deoxynucleoside kinases: implications for mitochondrial toxicity of antiviral nucleoside analogs.
    Sun R; Eriksson S; Wang L
    Antimicrob Agents Chemother; 2014 Nov; 58(11):6758-66. PubMed ID: 25182642
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Long term expression of Drosophila melanogaster nucleoside kinase in thymidine kinase 2-deficient mice with no lethal effects caused by nucleotide pool imbalances.
    Krishnan S; Paredes JA; Zhou X; Kuiper RV; Hultenby K; Curbo S; Karlsson A
    J Biol Chem; 2014 Nov; 289(47):32835-44. PubMed ID: 25296759
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Bioavailability and cytosolic kinases modulate response to deoxynucleoside therapy in TK2 deficiency.
    Lopez-Gomez C; Hewan H; Sierra C; Akman HO; Sanchez-Quintero MJ; Juanola-Falgarona M; Tadesse S; Tanji K; Konofagou EE; Hirano M
    EBioMedicine; 2019 Aug; 46():356-367. PubMed ID: 31383553
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Targeted impairment of thymidine kinase 2 expression in cells induces mitochondrial DNA depletion and reveals molecular mechanisms of compensation of mitochondrial respiratory activity.
    Villarroya J; Lara MC; Dorado B; Garrido M; García-Arumí E; Meseguer A; Hirano M; Vilà MR
    Biochem Biophys Res Commun; 2011 Apr; 407(2):333-8. PubMed ID: 21382338
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Kinetic properties of mutant human thymidine kinase 2 suggest a mechanism for mitochondrial DNA depletion myopathy.
    Wang L; Saada A; Eriksson S
    J Biol Chem; 2003 Feb; 278(9):6963-8. PubMed ID: 12493767
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Thymidine kinase 2 enzyme kinetics elucidate the mechanism of thymidine-induced mitochondrial DNA depletion.
    Sun R; Wang L
    Biochemistry; 2014 Oct; 53(39):6142-50. PubMed ID: 25215937
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Targeted transgenic overexpression of mitochondrial thymidine kinase (TK2) alters mitochondrial DNA (mtDNA) and mitochondrial polypeptide abundance: transgenic TK2, mtDNA, and antiretrovirals.
    Hosseini SH; Kohler JJ; Haase CP; Tioleco N; Stuart T; Keebaugh E; Ludaway T; Russ R; Green E; Long R; Wang L; Eriksson S; Lewis W
    Am J Pathol; 2007 Mar; 170(3):865-74. PubMed ID: 17322372
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Tissue specific distribution of pyrimidine deoxynucleoside salvage enzymes shed light on the mechanism of mitochondrial DNA depletion.
    Wang L; Eriksson S
    Nucleosides Nucleotides Nucleic Acids; 2010 Jun; 29(4-6):400-3. PubMed ID: 20544526
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Thymidine kinase 2 mutations in autosomal recessive progressive external ophthalmoplegia with multiple mitochondrial DNA deletions.
    Tyynismaa H; Sun R; Ahola-Erkkilä S; Almusa H; Pöyhönen R; Korpela M; Honkaniemi J; Isohanni P; Paetau A; Wang L; Suomalainen A
    Hum Mol Genet; 2012 Jan; 21(1):66-75. PubMed ID: 21937588
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Basic biochemical characterization of cytosolic enzymes in thymidine nucleotide synthesis in adult rat tissues: implications for tissue specific mitochondrial DNA depletion and deoxynucleoside-based therapy for TK2-deficiency.
    Wang L; Sun R; Eriksson S
    BMC Mol Cell Biol; 2020 Apr; 21(1):33. PubMed ID: 32345222
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Murine cardiac mtDNA: effects of transgenic manipulation of nucleoside phosphorylation.
    Kohler JJ; Hosseini SH; Cucoranu I; Hoying-Brandt A; Green E; Johnson D; Wittich B; Srivastava J; Ivey K; Fields E; Russ R; Raper CM; Santoianni R; Lewis W
    Lab Invest; 2009 Feb; 89(2):122-30. PubMed ID: 19079325
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Identification and characterization of mitochondrial factors modulating thymidine kinase 2 activity.
    Sun R; Eriksson S; Wang L
    Nucleosides Nucleotides Nucleic Acids; 2010 Jun; 29(4-6):382-5. PubMed ID: 20544523
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Deoxyribonucleoside kinases in mitochondrial DNA depletion.
    Saada-Reisch A
    Nucleosides Nucleotides Nucleic Acids; 2004 Oct; 23(8-9):1205-15. PubMed ID: 15571232
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Cloning and characterization of full-length mouse thymidine kinase 2: the N-terminal sequence directs import of the precursor protein into mitochondria.
    Wang L; Eriksson S
    Biochem J; 2000 Oct; 351 Pt 2(Pt 2):469-76. PubMed ID: 11023833
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synergistic Deoxynucleoside and Gene Therapies for Thymidine Kinase 2 Deficiency.
    Lopez-Gomez C; Sanchez-Quintero MJ; Lee EJ; Kleiner G; Tadesse S; Xie J; Akman HO; Gao G; Hirano M
    Ann Neurol; 2021 Oct; 90(4):640-652. PubMed ID: 34338329
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Mutant mitochondrial thymidine kinase in mitochondrial DNA depletion myopathy.
    Saada A; Shaag A; Mandel H; Nevo Y; Eriksson S; Elpeleg O
    Nat Genet; 2001 Nov; 29(3):342-4. PubMed ID: 11687801
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.