These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

132 related articles for article (PubMed ID: 1846000)

  • 1. The regulatory role of known tyrosine autophosphorylation sites of the insulin receptor kinase domain. An assessment by replacement with neutral and negatively charged amino acids.
    Zhang B; Tavaré JM; Ellis L; Roth RA
    J Biol Chem; 1991 Jan; 266(2):990-6. PubMed ID: 1846000
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Insulin receptor kinase domain autophosphorylation regulates receptor enzymatic function.
    Wilden PA; Kahn CR; Siddle K; White MF
    J Biol Chem; 1992 Aug; 267(23):16660-8. PubMed ID: 1322912
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Enhanced insulin-induced mitogenesis and mitogen-activated protein kinase activities in mutant insulin receptors with substitution of two COOH-terminal tyrosine autophosphorylation sites by phenylalanine.
    Ando A; Momomura K; Tobe K; Yamamoto-Honda R; Sakura H; Tamori Y; Kaburagi Y; Koshio O; Akanuma Y; Yazaki Y
    J Biol Chem; 1992 Jun; 267(18):12788-96. PubMed ID: 1618780
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Analysis of the order of autophosphorylation of human insulin receptor tyrosines 1158, 1162 and 1163.
    Dickens M; Tavaré JM
    Biochem Biophys Res Commun; 1992 Jul; 186(1):244-50. PubMed ID: 1321605
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Assessment of the in situ tyrosine kinase activity of mutant insulin receptors lacking tyrosine autophosphorylation sites 1162 and 1163.
    Yonezawa K; Roth RA
    Mol Endocrinol; 1991 Feb; 5(2):194-200. PubMed ID: 1710030
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Insulin-stimulated serine and threonine phosphorylation of the human insulin receptor. An assessment of the role of serines 1305/1306 and threonine 1348 by their replacement with neutral or negatively charged amino acids.
    Tavaré JM; Zhang B; Ellis L; Roth RA
    J Biol Chem; 1991 Nov; 266(32):21804-9. PubMed ID: 1939203
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Substrate phosphorylation catalyzed by the insulin receptor tyrosine kinase. Kinetic correlation to autophosphorylation of specific sites in the beta subunit.
    Flores-Riveros JR; Sibley E; Kastelic T; Lane MD
    J Biol Chem; 1989 Dec; 264(36):21557-72. PubMed ID: 2557333
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Monoclonal antibodies mimic insulin activation of ribosomal protein S6 kinase without activation of insulin receptor tyrosine kinase. Studies in cells transfected with normal and mutant human insulin receptors.
    Sung CK; Maddux BA; Hawley DM; Goldfine ID
    J Biol Chem; 1989 Nov; 264(32):18951-9. PubMed ID: 2553727
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Analysis of insulin receptor phosphorylation sites in intact rat liver cells by two-dimensional phosphopeptide mapping. Predominance of the tris-phosphorylated form of the kinase domain after stimulation by insulin.
    Issad T; Tavaré JM; Denton RM
    Biochem J; 1991 Apr; 275 ( Pt 1)(Pt 1):15-21. PubMed ID: 1708233
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Kinase inhibition by a phosphorylated peptide corresponding to the major insulin receptor autophosphorylation domain.
    Chavanieu A; Calas B; Vaglio P; Grigorescu F
    Eur J Biochem; 1992 Sep; 208(2):367-73. PubMed ID: 1381676
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose.
    Ellis L; Clauser E; Morgan DO; Edery M; Roth RA; Rutter WJ
    Cell; 1986 Jun; 45(5):721-32. PubMed ID: 3518947
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Two-dimensional phosphopeptide analysis of the autophosphorylation cascade of a soluble insulin receptor tyrosine kinase. The tyrosines phosphorylated are typical of those observed following phosphorylation of the heterotetrameric insulin receptor in intact cells.
    Tavaré JM; Clack B; Ellis L
    J Biol Chem; 1991 Jan; 266(3):1390-5. PubMed ID: 1703148
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Relationship of site-specific beta subunit tyrosine autophosphorylation to insulin activation of the insulin receptor (tyrosine) protein kinase activity.
    Tornqvist HE; Avruch J
    J Biol Chem; 1988 Apr; 263(10):4593-601. PubMed ID: 2832399
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The role of insulin receptor kinase domain autophosphorylation in receptor-mediated activities. Analysis with insulin and anti-receptor antibodies.
    Wilden PA; Siddle K; Haring E; Backer JM; White MF; Kahn CR
    J Biol Chem; 1992 Jul; 267(19):13719-27. PubMed ID: 1320027
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Monoclonal antibody to the human insulin receptor, but not insulin, stimulates S6 kinase via human insulin receptors mutated at three major tyrosine autophosphorylation sites.
    Sung CK
    J Cell Biochem; 1992 Mar; 48(3):324-35. PubMed ID: 1328257
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity.
    Argetsinger LS; Kouadio JL; Steen H; Stensballe A; Jensen ON; Carter-Su C
    Mol Cell Biol; 2004 Jun; 24(11):4955-67. PubMed ID: 15143187
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Tumorigenic and mitogenic capacities are reduced in transfected fibroblasts expressing mutant insulin-like growth factor (IGF)-I receptors. The role of tyrosine residues 1250, 1251, and 1316 in the carboxy-terminus of the IGF-I receptor.
    Blakesley VA; Kalebic T; Helman LJ; Stannard B; Faria TN; Roberts CT; LeRoith D
    Endocrinology; 1996 Feb; 137(2):410-7. PubMed ID: 8593783
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Mutation of the two carboxyl-terminal tyrosines in the insulin receptor results in enhanced activation of mitogen-activated protein kinase.
    Pang L; Milarski KL; Ohmichi M; Takata Y; Olefsky JM; Saltiel AR
    J Biol Chem; 1994 Apr; 269(14):10604-8. PubMed ID: 8144649
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Multiple autophosphorylation sites of the epidermal growth factor receptor are essential for receptor kinase activity and internalization. Contrasting significance of tyrosine 992 in the native and truncated receptors.
    Sorkin A; Helin K; Waters CM; Carpenter G; Beguinot L
    J Biol Chem; 1992 Apr; 267(12):8672-8. PubMed ID: 1314835
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Kinetic properties of the insulin receptor tyrosine protein kinase: activation through an insulin-stimulated tyrosine-specific, intramolecular autophosphorylation.
    Kwok YC; Nemenoff RA; Powers AC; Avruch J
    Arch Biochem Biophys; 1986 Jan; 244(1):102-13. PubMed ID: 3004334
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.