BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

359 related articles for article (PubMed ID: 18473723)

  • 1. Tyrosyl-DNA phosphodiesterase as a target for anticancer therapy.
    Dexheimer TS; Antony S; Marchand C; Pommier Y
    Anticancer Agents Med Chem; 2008 May; 8(4):381-9. PubMed ID: 18473723
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Tyrosyl-DNA phosphodiesterase (Tdp1) (3'-phosphotyrosyl DNA phosphodiesterase).
    Raymond AC; Burgin AB
    Methods Enzymol; 2006; 409():511-24. PubMed ID: 16793421
    [TBL] [Abstract][Full Text] [Related]  

  • 3. 4-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesulfonate) (NSC 88915) and related novel steroid derivatives as tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors.
    Dexheimer TS; Gediya LK; Stephen AG; Weidlich I; Antony S; Marchand C; Interthal H; Nicklaus M; Fisher RJ; Njar VC; Pommier Y
    J Med Chem; 2009 Nov; 52(22):7122-31. PubMed ID: 19883083
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Synthesis of Methoxy-, Methylenedioxy-, Hydroxy-, and Halo-Substituted Benzophenanthridinone Derivatives as DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Inhibitors and Their Biological Activity for Drug-Resistant Cancer.
    Hu DX; Tang WL; Zhang Y; Yang H; Wang W; Agama K; Pommier Y; An LK
    J Med Chem; 2021 Jun; 64(11):7617-7629. PubMed ID: 34008967
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Discovery, Synthesis, and Evaluation of Oxynitidine Derivatives as Dual Inhibitors of DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1), and Potential Antitumor Agents.
    Zhang XR; Wang HW; Tang WL; Zhang Y; Yang H; Hu DX; Ravji A; Marchand C; Kiselev E; Ofori-Atta K; Agama K; Pommier Y; An LK
    J Med Chem; 2018 Nov; 61(22):9908-9930. PubMed ID: 30336023
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) inhibitors.
    Huang SN; Pommier Y; Marchand C
    Expert Opin Ther Pat; 2011 Sep; 21(9):1285-92. PubMed ID: 21843105
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis and biological evaluation of indenoisoquinolines that inhibit both tyrosyl-DNA phosphodiesterase I (Tdp1) and topoisomerase I (Top1).
    Conda-Sheridan M; Reddy PV; Morrell A; Cobb BT; Marchand C; Agama K; Chergui A; Renaud A; Stephen AG; Bindu LK; Pommier Y; Cushman M
    J Med Chem; 2013 Jan; 56(1):182-200. PubMed ID: 23259865
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Tyrosyl-DNA phosphodiesterase 2 (TDP2) repairs topoisomerase 1 DNA-protein crosslinks and 3'-blocking lesions in the absence of tyrosyl-DNA phosphodiesterase 1 (TDP1).
    Tsuda M; Kitamasu K; Kumagai C; Sugiyama K; Nakano T; Ide H
    DNA Repair (Amst); 2020; 91-92():102849. PubMed ID: 32460231
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Natural Products and Their Derivatives as Inhibitors of the DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1.
    Zakharenko AL; Luzina OA; Chepanova AA; Dyrkheeva NS; Salakhutdinov NF; Lavrik OI
    Int J Mol Sci; 2023 Mar; 24(6):. PubMed ID: 36982848
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Tyrosyl-DNA phosphodiesterase 1 targeting for modulation of camptothecin-based treatment.
    Beretta GL; Cossa G; Gatti L; Zunino F; Perego P
    Curr Med Chem; 2010; 17(15):1500-8. PubMed ID: 20166932
    [TBL] [Abstract][Full Text] [Related]  

  • 11. SCAN1 mutant Tdp1 accumulates the enzyme--DNA intermediate and causes camptothecin hypersensitivity.
    Interthal H; Chen HJ; Kehl-Fie TE; Zotzmann J; Leppard JB; Champoux JJ
    EMBO J; 2005 Jun; 24(12):2224-33. PubMed ID: 15920477
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs DNA damage induced by topoisomerases I and II and base alkylation in vertebrate cells.
    Murai J; Huang SY; Das BB; Dexheimer TS; Takeda S; Pommier Y
    J Biol Chem; 2012 Apr; 287(16):12848-57. PubMed ID: 22375014
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Dual DNA topoisomerase 1 and tyrosyl-DNA phosphodiesterase 1 inhibition for improved anticancer activity.
    Zakharenko A; Dyrkheeva N; Lavrik O
    Med Res Rev; 2019 Jul; 39(4):1427-1441. PubMed ID: 31004352
    [TBL] [Abstract][Full Text] [Related]  

  • 14. 5-Arylidenethioxothiazolidinones as inhibitors of tyrosyl-DNA phosphodiesterase I.
    Sirivolu VR; Vernekar SK; Marchand C; Naumova A; Chergui A; Renaud A; Stephen AG; Chen F; Sham YY; Pommier Y; Wang Z
    J Med Chem; 2012 Oct; 55(20):8671-84. PubMed ID: 23006064
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Tyrosyl-DNA phosphodiesterase I resolves both naturally and chemically induced DNA adducts and its potential as a therapeutic target.
    Comeaux EQ; van Waardenburg RC
    Drug Metab Rev; 2014 Nov; 46(4):494-507. PubMed ID: 25327705
    [TBL] [Abstract][Full Text] [Related]  

  • 16. [Tyrosyl-DNA Phosphodiesterase 1 Is a New Player in Repair of Apurinic/Apyrimidinic Sites].
    Rechkunova NI; Lebedeva NA; Lavrik OI
    Bioorg Khim; 2015; 41(5):531-8. PubMed ID: 26762090
    [TBL] [Abstract][Full Text] [Related]  

  • 17. TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1.
    Zeng Z; Sharma A; Ju L; Murai J; Umans L; Vermeire L; Pommier Y; Takeda S; Huylebroeck D; Caldecott KW; El-Khamisy SF
    Nucleic Acids Res; 2012 Sep; 40(17):8371-80. PubMed ID: 22740648
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Role of tyrosyl-DNA phosphodiesterase (TDP1) in mitochondria.
    Das BB; Dexheimer TS; Maddali K; Pommier Y
    Proc Natl Acad Sci U S A; 2010 Nov; 107(46):19790-5. PubMed ID: 21041670
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis and evaluation of aryliden- and hetarylidenfuranone derivatives of usnic acid as highly potent Tdp1 inhibitors.
    Zakharova O; Luzina O; Zakharenko A; Sokolov D; Filimonov A; Dyrkheeva N; Chepanova A; Ilina E; Ilyina A; Klabenkova K; Chelobanov B; Stetsenko D; Zafar A; Eurtivong C; Reynisson J; Volcho K; Salakhutdinov N; Lavrik O
    Bioorg Med Chem; 2018 Aug; 26(15):4470-4480. PubMed ID: 30076000
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Inhibition of human tyrosyl-DNA phosphodiesterase by aminoglycoside antibiotics and ribosome inhibitors.
    Liao Z; Thibaut L; Jobson A; Pommier Y
    Mol Pharmacol; 2006 Jul; 70(1):366-72. PubMed ID: 16618796
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 18.