BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

553 related articles for article (PubMed ID: 18474425)

  • 1. IRAK-4 inhibitors. Part 1: a series of amides.
    Buckley GM; Gowers L; Higueruelo AP; Jenkins K; Mack SR; Morgan T; Parry DM; Pitt WR; Rausch O; Richard MD; Sabin V; Fraser JL
    Bioorg Med Chem Lett; 2008 Jun; 18(11):3211-4. PubMed ID: 18474425
    [TBL] [Abstract][Full Text] [Related]  

  • 2. IRAK-4 inhibitors. Part II: a structure-based assessment of imidazo[1,2-a]pyridine binding.
    Buckley GM; Ceska TA; Fraser JL; Gowers L; Groom CR; Higueruelo AP; Jenkins K; Mack SR; Morgan T; Parry DM; Pitt WR; Rausch O; Richard MD; Sabin V
    Bioorg Med Chem Lett; 2008 Jun; 18(11):3291-5. PubMed ID: 18482836
    [TBL] [Abstract][Full Text] [Related]  

  • 3. IRAK-4 inhibitors. Part III: a series of imidazo[1,2-a]pyridines.
    Buckley GM; Fosbeary R; Fraser JL; Gowers L; Higueruelo AP; James LA; Jenkins K; Mack SR; Morgan T; Parry DM; Pitt WR; Rausch O; Richard MD; Sabin V
    Bioorg Med Chem Lett; 2008 Jun; 18(12):3656-60. PubMed ID: 18501603
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Design, synthesis, and structure-activity relationship of indole-3-glyoxylamide libraries possessing highly potent activity in a cell line model of prion disease.
    Thompson MJ; Borsenberger V; Louth JC; Judd KE; Chen B
    J Med Chem; 2009 Dec; 52(23):7503-11. PubMed ID: 19842664
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Pyridine amides as potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.
    Wang H; Ruan Z; Li JJ; Simpkins LM; Smirk RA; Wu SC; Hutchins RD; Nirschl DS; Van Kirk K; Cooper CB; Sutton JC; Ma Z; Golla R; Seethala R; Salyan ME; Nayeem A; Krystek SR; Sheriff S; Camac DM; Morin PE; Carpenter B; Robl JA; Zahler R; Gordon DA; Hamann LG
    Bioorg Med Chem Lett; 2008 Jun; 18(11):3168-72. PubMed ID: 18485702
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Quantitative structure-activity relationship (QSAR) study of interleukin-1 receptor associated kinase 4 (IRAK-4) inhibitor activity by the genetic algorithm and multiple linear regression (GA-MLR) method.
    Pourbasheer E; Riahi S; Ganjali MR; Norouzi P
    J Enzyme Inhib Med Chem; 2010 Dec; 25(6):844-53. PubMed ID: 20429783
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Design and synthesis of 5,6-fused heterocyclic amides as Raf kinase inhibitors.
    Ramurthy S; Aikawa M; Amiri P; Costales A; Hashash A; Jansen JM; Lin S; Ma S; Renhowe PA; Shafer CM; Subramanian S; Sung L; Verhagen J
    Bioorg Med Chem Lett; 2011 Jun; 21(11):3286-9. PubMed ID: 21543226
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Dipyridyl amides: potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists.
    Bonnefous C; Vernier JM; Hutchinson JH; Chung J; Reyes-Manalo G; Kamenecka T
    Bioorg Med Chem Lett; 2005 Feb; 15(4):1197-200. PubMed ID: 15686941
    [TBL] [Abstract][Full Text] [Related]  

  • 9. A practical synthesis of Rho-Kinase inhibitor Y-27632 and fluoro derivatives and their evaluation in human pluripotent stem cells.
    Paleček J; Zweigerdt R; Olmer R; Martin U; Kirschning A; Dräger G
    Org Biomol Chem; 2011 Aug; 9(15):5503-10. PubMed ID: 21677986
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Development of potent inhibitors of pyocyanin production in Pseudomonas aeruginosa.
    Miller LC; O'Loughlin CT; Zhang Z; Siryaporn A; Silpe JE; Bassler BL; Semmelhack MF
    J Med Chem; 2015 Feb; 58(3):1298-306. PubMed ID: 25597392
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis and evaluation of 4-(1-aminoalkyl)-N-(4-pyridyl)cyclohexanecarboxamides as Rho kinase inhibitors and neurite outgrowth promoters.
    Gingras K; Avedissian H; Thouin E; Boulanger V; Essagian C; McKerracher L; Lubell WD
    Bioorg Med Chem Lett; 2004 Oct; 14(19):4931-4. PubMed ID: 15341954
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Design and synthesis of 6,6-fused heterocyclic amides as raf kinase inhibitors.
    Ramurthy S; Costales A; Jansen JM; Levine B; Renhowe PA; Shafer CM; Subramanian S
    Bioorg Med Chem Lett; 2012 Feb; 22(4):1678-81. PubMed ID: 22264479
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Design and synthesis of novel amide AKT1 inhibitors with selectivity over CDK2.
    Ashton KS; St Jean DJ; Poon SF; Lee MR; Allen JG; Zhang S; Lofgren JA; Zhang X; Fotsch C; Hungate R
    Bioorg Med Chem Lett; 2011 Sep; 21(18):5191-6. PubMed ID: 21824779
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Structure-based optimization of potent 4- and 6-azaindole-3-carboxamides as renin inhibitors.
    Scheiper B; Matter H; Steinhagen H; Böcskei Z; Fleury V; McCort G
    Bioorg Med Chem Lett; 2011 Sep; 21(18):5480-6. PubMed ID: 21840218
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Design and campaign synthesis of pyridine-based histone deacetylase inhibitors.
    Andrews DM; Gibson KM; Graham MA; Matusiak ZS; Roberts CA; Stokes ES; Brady MC; Chresta CM
    Bioorg Med Chem Lett; 2008 Apr; 18(8):2525-9. PubMed ID: 18378451
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis and biological evaluation of a chitobiose-based peptide N-glycanase inhibitor library.
    Witte MD; Horst D; Wiertz EJ; van der Marel GA; Overkleeft HS
    J Org Chem; 2009 Jan; 74(2):605-16. PubMed ID: 19072094
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Design and synthesis of 3,7-diarylimidazopyridines as inhibitors of the VEGF-receptor KDR.
    Wu Z; Fraley ME; Bilodeau MT; Kaufman ML; Tasber ES; Balitza AE; Hartman GD; Coll KE; Rickert K; Shipman J; Shi B; Sepp-Lorenzino L; Thomas KA
    Bioorg Med Chem Lett; 2004 Feb; 14(4):909-12. PubMed ID: 15012992
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Aminoimidazo[1,2-a]pyridines as a new structural class of cyclin-dependent kinase inhibitors. Part 1: Design, synthesis, and biological evaluation.
    Jaramillo C; de Diego JE; Hamdouchi C; Collins E; Keyser H; Sánchez-Martínez C; del Prado M; Norman B; Brooks HB; Watkins SA; Spencer CD; Dempsey JA; Anderson BD; Campbell RM; Leggett T; Patel B; Schultz RM; Espinosa J; Vieth M; Zhang F; Timm DE
    Bioorg Med Chem Lett; 2004 Dec; 14(24):6095-9. PubMed ID: 15546737
    [TBL] [Abstract][Full Text] [Related]  

  • 19. "Click" synthesis of small-molecule inhibitors targeting caspases.
    Ng SL; Yang PY; Chen KY; Srinivasan R; Yao SQ
    Org Biomol Chem; 2008 Mar; 6(5):844-7. PubMed ID: 18292873
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors.
    Han Y; Giroux A; Colucci J; Bayly CI; Mckay DJ; Roy S; Xanthoudakis S; Vaillancourt J; Rasper DM; Tam J; Tawa P; Nicholson DW; Zamboni RJ
    Bioorg Med Chem Lett; 2005 Feb; 15(4):1173-80. PubMed ID: 15686936
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 28.