118 related articles for article (PubMed ID: 18474896)
1. Evaluation of fluorescence- and mass spectrometry-based CYP inhibition assays for use in drug discovery.
Bell L; Bickford S; Nguyen PH; Wang J; He T; Zhang B; Friche Y; Zimmerlin A; Urban L; Bojanic D
J Biomol Screen; 2008 Jun; 13(5):343-53. PubMed ID: 18474896
[TBL] [Abstract][Full Text] [Related]
2. Use of stable isotope labeled probes to facilitate liquid chromatography/mass spectrometry based high-throughput screening of time-dependent CYP inhibitors.
Dasgupta M; Tang W; Caldwell GW; Yan Z
Rapid Commun Mass Spectrom; 2010 Aug; 24(15):2177-85. PubMed ID: 20583325
[TBL] [Abstract][Full Text] [Related]
3. Development of a high-throughput online solid-phase extraction/tandem mass spectrometry method for cytochrome P450 inhibition screening.
Lim KB; Ozbal CC; Kassel DB
J Biomol Screen; 2010 Apr; 15(4):447-52. PubMed ID: 20208033
[TBL] [Abstract][Full Text] [Related]
4. High-throughput cytochrome P450 inhibition assays using laser diode thermal desorption-atmospheric pressure chemical ionization-tandem mass spectrometry.
Wu J; Hughes CS; Picard P; Letarte S; Gaudreault M; Lévesque JF; Nicoll-Griffith DA; Bateman KP
Anal Chem; 2007 Jun; 79(12):4657-65. PubMed ID: 17497828
[TBL] [Abstract][Full Text] [Related]
5. In vitro drug interactions of cytochrome p450: an evaluation of fluorogenic to conventional substrates.
Cohen LH; Remley MJ; Raunig D; Vaz AD
Drug Metab Dispos; 2003 Aug; 31(8):1005-15. PubMed ID: 12867489
[TBL] [Abstract][Full Text] [Related]
6. Comparison of cytochrome P450 inhibition assays for drug discovery using human liver microsomes with LC-MS, rhCYP450 isozymes with fluorescence, and double cocktail with LC-MS.
Di L; Kerns EH; Li SQ; Carter GT
Int J Pharm; 2007 Apr; 335(1-2):1-11. PubMed ID: 17137735
[TBL] [Abstract][Full Text] [Related]
7. Analytical approaches to determine cytochrome P450 inhibitory potential of new chemical entities in drug discovery.
Smith D; Sadagopan N; Zientek M; Reddy A; Cohen L
J Chromatogr B Analyt Technol Biomed Life Sci; 2007 May; 850(1-2):455-63. PubMed ID: 17270503
[TBL] [Abstract][Full Text] [Related]
8. Validated method for rapid inhibition screening of six cytochrome P450 enzymes by liquid chromatography-tandem mass spectrometry.
Li X; Chen X; Li Q; Wang L; Zhong D
J Chromatogr B Analyt Technol Biomed Life Sci; 2007 Jun; 852(1-2):128-37. PubMed ID: 17267297
[TBL] [Abstract][Full Text] [Related]
9. High-throughput, 384-well, LC-MS/MS CYP inhibition assay using automation, cassette-analysis technique, and streamlined data analysis.
Halladay JS; Delarosa EM; Tran D; Wang L; Wong S; Khojasteh SC
Drug Metab Lett; 2011 Aug; 5(3):220-30. PubMed ID: 21867481
[TBL] [Abstract][Full Text] [Related]
10. Evaluation of laser diode thermal desorption (LDTD) coupled with tandem mass spectrometry (MS/MS) for support of in vitro drug discovery assays: increasing scope, robustness and throughput of the LDTD technique for use with chemically diverse compound libraries.
Beattie I; Smith A; Weston DJ; White P; Szwandt S; Sealey L
J Pharm Biomed Anal; 2012 Feb; 59():18-28. PubMed ID: 22071442
[TBL] [Abstract][Full Text] [Related]
11. Simultaneous determination of multiple CYP inhibition constants using a cocktail-probe approach.
Zientek M; Youdim K
Methods Mol Biol; 2013; 987():11-23. PubMed ID: 23475664
[TBL] [Abstract][Full Text] [Related]
12. High-throughput cytochrome p450 inhibition assays by ultrafast gradient liquid chromatography with tandem mass spectrometry using monolithic columns.
Peng SX; Barbone AG; Ritchie DM
Rapid Commun Mass Spectrom; 2003; 17(6):509-18. PubMed ID: 12621611
[TBL] [Abstract][Full Text] [Related]
13. Utility of a column-switching LC/MS/MS method in cytochrome P450 inhibition assays using human liver microsomes.
Behera D; Pattem R; Kumar MS; Gudi GS
Drug Metabol Drug Interact; 2013; 28(3):177-85. PubMed ID: 23729559
[TBL] [Abstract][Full Text] [Related]
14. A novel incubation direct injection LC/MS/MS technique for in vitro drug metabolism screening studies involving the CYP 2D6 and the CYP 3A4 isozymes.
Bhoopathy S; Xin B; Unger SE; Karnes HT
J Pharm Biomed Anal; 2005 Apr; 37(4):739-49. PubMed ID: 15797796
[TBL] [Abstract][Full Text] [Related]
15. Simultaneous determination of tolbutamide, omeprazole, midazolam and dextromethorphan in human plasma by LC-MS/MS--a high throughput approach to evaluate drug-drug interactions.
Zhang W; Han F; Guo P; Zhao H; Lin ZJ; Huang MQ; Bertelsen K; Weng N
J Chromatogr B Analyt Technol Biomed Life Sci; 2010 May; 878(15-16):1169-77. PubMed ID: 20378422
[TBL] [Abstract][Full Text] [Related]
16. Automated high throughput ADME assays for metabolic stability and cytochrome P450 inhibition profiling of combinatorial libraries.
Jenkins KM; Angeles R; Quintos MT; Xu R; Kassel DB; Rourick RA
J Pharm Biomed Anal; 2004 Mar; 34(5):989-1004. PubMed ID: 15019033
[TBL] [Abstract][Full Text] [Related]
17. High-throughput cytochrome P450 (CYP) inhibition screening via cassette probe-dosing strategy. I. Development of direct injection/on-line guard cartridge extraction/tandem mass spectrometry for the simultaneous detection of CYP probe substrates and their metabolites.
Bu HZ; Magis L; Knuth K; Teitelbaum P
Rapid Commun Mass Spectrom; 2000; 14(17):1619-24. PubMed ID: 10960916
[TBL] [Abstract][Full Text] [Related]
18. Quantitative protein determination for CYP induction via LC-MS/MS.
Williamson BL; Purkayastha S; Hunter CL; Nuwaysir L; Hill J; Easterwood L; Hill J
Proteomics; 2011 Jan; 11(1):33-41. PubMed ID: 21182192
[TBL] [Abstract][Full Text] [Related]
19. Application of higher throughput screening (HTS) inhibition assays to evaluate the interaction of antiparasitic drugs with cytochrome P450s.
Bapiro TE; Egnell AC; Hasler JA; Masimirembwa CM
Drug Metab Dispos; 2001 Jan; 29(1):30-5. PubMed ID: 11124226
[TBL] [Abstract][Full Text] [Related]
20. Cytochrome P450 inhibition using recombinant proteins and mass spectrometry/multiple reaction monitoring technology in a cassette incubation.
Weaver R; Graham KS; Beattie IG; Riley RJ
Drug Metab Dispos; 2003 Jul; 31(7):955-66. PubMed ID: 12814974
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
