These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
156 related articles for article (PubMed ID: 18476739)
1. Understanding microscopic binding of human microsomal prostaglandin E synthase-1 with substrates and inhibitors by molecular modeling and dynamics simulation. Hamza A; Abdulhameed MD; Zhan CG J Phys Chem B; 2008 Jun; 112(24):7320-9. PubMed ID: 18476739 [TBL] [Abstract][Full Text] [Related]
2. Understanding microscopic binding of human microsomal prostaglandin E synthase-1 (mPGES-1) trimer with substrate PGH2 and cofactor GSH: insights from computational alanine scanning and site-directed mutagenesis. Hamza A; Tong M; AbdulHameed MD; Liu J; Goren AC; Tai HH; Zhan CG J Phys Chem B; 2010 Apr; 114(16):5605-16. PubMed ID: 20369883 [TBL] [Abstract][Full Text] [Related]
3. Structural and functional characterization of human microsomal prostaglandin E synthase-1 by computational modeling and site-directed mutagenesis. Huang X; Yan W; Gao D; Tong M; Tai HH; Zhan CG Bioorg Med Chem; 2006 May; 14(10):3553-62. PubMed ID: 16439136 [TBL] [Abstract][Full Text] [Related]
4. Murine mPGES-1 3D structure elucidation and inhibitors binding mode predictions by homology modeling and site-directed mutagenesis. Corso G; Coletta I; Ombrato R J Chem Inf Model; 2013 Jul; 53(7):1804-17. PubMed ID: 23789712 [TBL] [Abstract][Full Text] [Related]
5. Homo-timeric structural model of human microsomal prostaglandin E synthase-1 and characterization of its substrate/inhibitor binding interactions. Xing L; Kurumbail RG; Frazier RB; Davies MS; Fujiwara H; Weinberg RA; Gierse JK; Caspers N; Carter JS; McDonald JJ; Moore WM; Vazquez ML J Comput Aided Mol Des; 2009 Jan; 23(1):13-24. PubMed ID: 18777160 [TBL] [Abstract][Full Text] [Related]
6. Human microsomal prostaglandin E synthase-1 (mPGES-1) binding with inhibitors and the quantitative structure-activity correlation. AbdulHameed MD; Hamza A; Liu J; Huang X; Zhan CG J Chem Inf Model; 2008 Jan; 48(1):179-85. PubMed ID: 18052142 [TBL] [Abstract][Full Text] [Related]
7. PGH2 degradation pathway catalyzed by GSH-heme complex bound microsomal prostaglandin E2 synthase type 2: the first example of a dual-function enzyme. Yamada T; Takusagawa F Biochemistry; 2007 Jul; 46(28):8414-24. PubMed ID: 17585783 [TBL] [Abstract][Full Text] [Related]
8. Molecular docking and competitive binding study discovered different binding modes of microsomal prostaglandin E synthase-1 inhibitors. He S; Lai L J Chem Inf Model; 2011 Dec; 51(12):3254-61. PubMed ID: 22077876 [TBL] [Abstract][Full Text] [Related]
9. Crystal Structures of mPGES-1 Inhibitor Complexes Form a Basis for the Rational Design of Potent Analgesic and Anti-Inflammatory Therapeutics. Luz JG; Antonysamy S; Kuklish SL; Condon B; Lee MR; Allison D; Yu XP; Chandrasekhar S; Backer R; Zhang A; Russell M; Chang SS; Harvey A; Sloan AV; Fisher MJ J Med Chem; 2015 Jun; 58(11):4727-37. PubMed ID: 25961169 [TBL] [Abstract][Full Text] [Related]
10. Novel human mPGES-1 inhibitors identified through structure-based virtual screening. Hamza A; Zhao X; Tong M; Tai HH; Zhan CG Bioorg Med Chem; 2011 Oct; 19(20):6077-86. PubMed ID: 21920764 [TBL] [Abstract][Full Text] [Related]
11. Fragment-based discovery of novel and selective mPGES-1 inhibitors Part 1: identification of sulfonamido-1,2,3-triazole-4,5-dicarboxylic acid. Lee K; Pham VC; Choi MJ; Kim KJ; Lee KT; Han SG; Yu YG; Lee JY Bioorg Med Chem Lett; 2013 Jan; 23(1):75-80. PubMed ID: 23218602 [TBL] [Abstract][Full Text] [Related]
12. Mutation of a critical arginine in microsomal prostaglandin E synthase-1 shifts the isomerase activity to a reductase activity that converts prostaglandin H2 into prostaglandin F2alpha. Hammarberg T; Hamberg M; Wetterholm A; Hansson H; Samuelsson B; Haeggstro M JZ J Biol Chem; 2009 Jan; 284(1):301-305. PubMed ID: 18984580 [TBL] [Abstract][Full Text] [Related]
13. Microsomal prostaglandin E synthase-1 exhibits one-third-of-the-sites reactivity. He S; Wu Y; Yu D; Lai L Biochem J; 2011 Nov; 440(1):13-21. PubMed ID: 21797823 [TBL] [Abstract][Full Text] [Related]
14. Exploration of the dihydropyrimidine scaffold for the development of new potential anti-inflammatory agents blocking prostaglandin E₂ synthase-1 enzyme (mPGES-1). Lauro G; Strocchia M; Terracciano S; Bruno I; Fischer K; Pergola C; Werz O; Riccio R; Bifulco G Eur J Med Chem; 2014 Jun; 80():407-15. PubMed ID: 24794772 [TBL] [Abstract][Full Text] [Related]
15. Discovery of highly potent microsomal prostaglandin e2 synthase 1 inhibitors using the active conformation structural model and virtual screen. He S; Li C; Liu Y; Lai L J Med Chem; 2013 Apr; 56(8):3296-309. PubMed ID: 23527738 [TBL] [Abstract][Full Text] [Related]
16. Insights into the structure activity relationship of mPGES-1 inhibitors: Hints for better inhibitor design. Gupta A; Aparoy P Int J Biol Macromol; 2016 Jul; 88():624-32. PubMed ID: 27012893 [TBL] [Abstract][Full Text] [Related]
17. Structure of the extracellular glutathione S-transferase OvGST1 from the human pathogenic parasite Onchocerca volvulus. Perbandt M; Höppner J; Burmeister C; Lüersen K; Betzel C; Liebau E J Mol Biol; 2008 Mar; 377(2):501-11. PubMed ID: 18258257 [TBL] [Abstract][Full Text] [Related]
18. Synthesis and biological evaluation of substituted benzoxazoles as inhibitors of mPGES-1: use of a conformation-based hypothesis to facilitate compound design. Walker DP; Arhancet GB; Lu HF; Heasley SE; Metz S; Kablaoui NM; Franco FM; Hanau CE; Scholten JA; Springer JR; Fobian YM; Carter JS; Xing L; Yang S; Shaffer AF; Jerome GM; Baratta MT; Moore WM; Vazquez ML Bioorg Med Chem Lett; 2013 Feb; 23(4):1120-6. PubMed ID: 23298810 [TBL] [Abstract][Full Text] [Related]
19. A Multi-step Virtual Screening Protocol for the Identification of Novel Non-acidic Microsomal Prostaglandin E Shekfeh S; Çalışkan B; Fischer K; Yalçın T; Garscha U; Werz O; Banoglu E ChemMedChem; 2019 Jan; 14(2):273-281. PubMed ID: 30537167 [TBL] [Abstract][Full Text] [Related]
20. Identification of key residues determining species differences in inhibitor binding of microsomal prostaglandin E synthase-1. Pawelzik SC; Uda NR; Spahiu L; Jegerschöld C; Stenberg P; Hebert H; Morgenstern R; Jakobsson PJ J Biol Chem; 2010 Sep; 285(38):29254-61. PubMed ID: 20605783 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]