83 related articles for article (PubMed ID: 18479927)
1. Synthesis and activity on rat aorta rings and rat pancreatic beta-cells of ring-opened analogues of benzopyran-type potassium channel activators.
Khelili S; Florence X; Bouhadja M; Abdelaziz S; Mechouch N; Mohamed Y; de Tullio P; Lebrun P; Pirotte B
Bioorg Med Chem; 2008 Jun; 16(11):6124-30. PubMed ID: 18479927
[TBL] [Abstract][Full Text] [Related]
2. Influence of the alkylsulfonylamino substituent located at the 6-position of 2,2-dimethylchromans structurally related to cromakalim: from potassium channel openers to calcium entry blockers?
Florence X; Desvaux V; Goffin E; de Tullio P; Pirotte B; Lebrun P
Eur J Med Chem; 2014 Jun; 80():36-46. PubMed ID: 24763361
[TBL] [Abstract][Full Text] [Related]
3. Design, synthesis, and pharmacological evaluation of R/S-3,4-dihydro-2,2-dimethyl- 6-halo-4-(phenylaminocarbonylamino)-2H-1-benzopyrans: toward tissue-selective pancreatic beta-cell KATP channel openers structurally related to (+/-)-cromakalim.
Sebille S; Gall D; de Tullio P; Florence X; Lebrun P; Pirotte B
J Med Chem; 2006 Jul; 49(15):4690-7. PubMed ID: 16854075
[TBL] [Abstract][Full Text] [Related]
4. New R/S-3,4-dihydro-2,2-dimethyl-6-halo-4-(phenylaminothiocarbonylamino)-2H-1-benzopyrans structurally related to (+/-)-cromakalim as tissue-selective pancreatic beta-cell K(ATP) channel openers.
Sebille S; de Tullio P; Florence X; Becker B; Antoine MH; Michaux C; Wouters J; Pirotte B; Lebrun P
Bioorg Med Chem; 2008 May; 16(10):5704-19. PubMed ID: 18406154
[TBL] [Abstract][Full Text] [Related]
5. New R/S-3,4-dihydro-2,2-dimethyl-2H-1-benzopyrans as K(ATP) channel openers: modulation of the 4-position.
Florence X; Sebille S; Tullio Pd; Lebrun P; Pirotte B
Bioorg Med Chem; 2009 Nov; 17(22):7723-31. PubMed ID: 19822435
[TBL] [Abstract][Full Text] [Related]
6. Modulation of the 6-position of benzopyran derivatives and inhibitory effects on the insulin releasing process.
Florence X; Dilly S; de Tullio P; Pirotte B; Lebrun P
Bioorg Med Chem; 2011 Jul; 19(13):3919-28. PubMed ID: 21664825
[TBL] [Abstract][Full Text] [Related]
7. 4,6-Disubstituted 2,2-dimethylchromans structurally related to the K(ATP) channel opener cromakalim: design, synthesis, and effect on insulin release and vascular tone.
Sebille S; de Tullio P; Becker B; Antoine MH; Boverie S; Pirotte B; Lebrun P
J Med Chem; 2005 Jan; 48(2):614-21. PubMed ID: 15658874
[TBL] [Abstract][Full Text] [Related]
8. 4-Phenylureido/thioureido-substituted 2,2-dimethylchroman analogs of cromakalim bearing a bulky 'carbamate' moiety at the 6-position as potent inhibitors of glucose-sensitive insulin secretion.
Pirotte B; Florence X; Goffin E; Medeiros MB; de Tullio P; Lebrun P
Eur J Med Chem; 2016 Oct; 121():338-351. PubMed ID: 27267004
[TBL] [Abstract][Full Text] [Related]
9. Synthesis and pharmacological evaluation of some N-arylsulfonyl-N-methyl-N'-(2,2-dimethyl-2H-1-benzopyran-4-yl)ureas structurally related to cromakalim.
Khelili S; Lebrun P; de Tullio P; Pirotte B
Bioorg Med Chem; 2006 May; 14(10):3530-4. PubMed ID: 16455262
[TBL] [Abstract][Full Text] [Related]
10. Synthesis and pharmacological activity of N-(2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl)-4H-1,2,4-benzothiadiazine-3-carboxamides 1,1-dioxides on rat uterus, rat aorta and rat pancreatic β-cells.
Khelili S; Kihal N; Yekhlef M; de Tullio P; Lebrun P; Pirotte B
Eur J Med Chem; 2012 Aug; 54():873-8. PubMed ID: 22647221
[TBL] [Abstract][Full Text] [Related]
11. Potassium channel activators based on the benzopyran substructure: synthesis and activity of the C-8 substituent.
Thompson R; Doggrell S; Hoberg JO
Bioorg Med Chem; 2003 Apr; 11(8):1663-8. PubMed ID: 12659752
[TBL] [Abstract][Full Text] [Related]
12. Design, synthesis and biological evaluation of novel ring-opened cromakalim analogues with relaxant effects on vascular and respiratory smooth muscles and as stimulators of elastin synthesis.
Bouhedja M; Peres B; Fhayli W; Ghandour Z; Boumendjel A; Faury G; Khelili S
Eur J Med Chem; 2018 Jan; 144():774-796. PubMed ID: 29291445
[TBL] [Abstract][Full Text] [Related]
13. The synthesis and biological evaluation of a range of novel functionalized benzopyrans as potential potassium channel activators.
Tyrrell E; Tesfa KH; Greenwood I; Mann A
Bioorg Med Chem Lett; 2008 Feb; 18(3):1237-40. PubMed ID: 18191566
[TBL] [Abstract][Full Text] [Related]
14. Toward tissue-selective pancreatic B-cells KATP channel openers belonging to 3-alkylamino-7-halo-4H-1,2,4-benzothiadiazine 1,1-dioxides.
de Tullio P; Becker B; Boverie S; Dabrowski M; Wahl P; Antoine MH; Somers F; Sebille S; Ouedraogo R; Hansen JB; Lebrun P; Pirotte B
J Med Chem; 2003 Jul; 46(15):3342-53. PubMed ID: 12852765
[TBL] [Abstract][Full Text] [Related]
15. Arylcyanoguanidines as activators of Kir6.2/SUR1K ATP channels and inhibitors of insulin release.
Tagmose TM; Schou SC; Mogensen JP; Nielsen FE; Arkhammar PO; Wahl P; Hansen BS; Worsaae A; Boonen HC; Antoine MH; Lebrun P; Hansen JB
J Med Chem; 2004 Jun; 47(12):3202-11. PubMed ID: 15163199
[TBL] [Abstract][Full Text] [Related]
16. Cardioselective antiischemic ATP-sensitive potassium channel openers. 2. Structure-activity studies on benzopyranylcyanoguanidines: modification of the benzopyran ring.
Atwal KS; Grover GJ; Ferrara FN; Ahmed SZ; Sleph PG; Dzwonczyk S; Normandin DE
J Med Chem; 1995 May; 38(11):1966-73. PubMed ID: 7783128
[TBL] [Abstract][Full Text] [Related]
17. Synthesis and biological activity of spirocyclic benzopyran imidazolone potassium channel openers.
Gadwood RC; Kamdar BV; Dubray LA; Wolfe ML; Smith MP; Watt W; Mizsak SA; Groppi VE
J Med Chem; 1993 May; 36(10):1480-7. PubMed ID: 8496916
[TBL] [Abstract][Full Text] [Related]
18. Design and synthesis of new potassium channel activators derived from the ring opening of diazoxide: study of their vasodilatory effect, stimulation of elastin synthesis and inhibitory effect on insulin release.
Bouider N; Fhayli W; Ghandour Z; Boyer M; Harrouche K; Florence X; Pirotte B; Lebrun P; Faury G; Khelili S
Bioorg Med Chem; 2015 Apr; 23(8):1735-46. PubMed ID: 25773016
[TBL] [Abstract][Full Text] [Related]
19. Impact of the nature of the substituent at the 3-position of 4H-1,2,4-benzothiadiazine 1,1-dioxides on their opening activity toward ATP-sensitive potassium channels.
Pirotte B; de Tullio P; Boverie S; Michaux C; Lebrun P
J Med Chem; 2011 May; 54(9):3188-99. PubMed ID: 21428460
[TBL] [Abstract][Full Text] [Related]
20. Synthesis and antihypertensive activity of 4-(diazabicyclo[4.1.0]-heptenyloxy)benzopyran derivatives and their analogues.
Horino H; Mimura T; Kagechika K; Ohta M; Kubo H; Kitagawa M
Chem Pharm Bull (Tokyo); 1998 Apr; 46(4):602-9. PubMed ID: 9579035
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
