These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

231 related articles for article (PubMed ID: 18490160)

  • 1. Discovery of N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide as an agonist of the alpha7 nicotinic acetylcholine receptor: in vitro and in vivo activity.
    Acker BA; Jacobsen EJ; Rogers BN; Wishka DG; Reitz SC; Piotrowski DW; Myers JK; Wolfe ML; Groppi VE; Thornburgh BA; Tinholt PM; Walters RR; Olson BA; Fitzgerald L; Staton BA; Raub TJ; Krause M; Li KS; Hoffmann WE; Hajos M; Hurst RS; Walker DP
    Bioorg Med Chem Lett; 2008 Jun; 18(12):3611-5. PubMed ID: 18490160
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the alpha7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: synthesis and structure--activity relationship.
    Wishka DG; Walker DP; Yates KM; Reitz SC; Jia S; Myers JK; Olson KL; Jacobsen EJ; Wolfe ML; Groppi VE; Hanchar AJ; Thornburgh BA; Cortes-Burgos LA; Wong EH; Staton BA; Raub TJ; Higdon NR; Wall TM; Hurst RS; Walters RR; Hoffmann WE; Hajos M; Franklin S; Carey G; Gold LH; Cook KK; Sands SB; Zhao SX; Soglia JR; Kalgutkar AS; Arneric SP; Rogers BN
    J Med Chem; 2006 Jul; 49(14):4425-36. PubMed ID: 16821801
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The selective alpha7 nicotinic acetylcholine receptor agonist PNU-282987 [N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide hydrochloride] enhances GABAergic synaptic activity in brain slices and restores auditory gating deficits in anesthetized rats.
    Hajós M; Hurst RS; Hoffmann WE; Krause M; Wall TM; Higdon NR; Groppi VE
    J Pharmacol Exp Ther; 2005 Mar; 312(3):1213-22. PubMed ID: 15523001
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The novel alpha7 nicotinic acetylcholine receptor agonist N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-[2-(methoxy)phenyl]-1-benzofuran-2-carboxamide improves working and recognition memory in rodents.
    Boess FG; De Vry J; Erb C; Flessner T; Hendrix M; Luithle J; Methfessel C; Riedl B; Schnizler K; van der Staay FJ; van Kampen M; Wiese WB; Koenig G
    J Pharmacol Exp Ther; 2007 May; 321(2):716-25. PubMed ID: 17308038
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Discovery of 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a novel alpha 7 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders in schizophrenia: synthesis, SAR development, and in vivo efficacy in cognition models.
    O'Donnell CJ; Rogers BN; Bronk BS; Bryce DK; Coe JW; Cook KK; Duplantier AJ; Evrard E; Hajós M; Hoffmann WE; Hurst RS; Maklad N; Mather RJ; McLean S; Nedza FM; O'Neill BT; Peng L; Qian W; Rottas MM; Sands SB; Schmidt AW; Shrikhande AV; Spracklin DK; Wong DF; Zhang A; Zhang L
    J Med Chem; 2010 Feb; 53(3):1222-37. PubMed ID: 20043678
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors.
    Bodnar AL; Cortes-Burgos LA; Cook KK; Dinh DM; Groppi VE; Hajos M; Higdon NR; Hoffmann WE; Hurst RS; Myers JK; Rogers BN; Wall TM; Wolfe ML; Wong E
    J Med Chem; 2005 Feb; 48(4):905-8. PubMed ID: 15715459
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Characterization of 2-[[4-fluoro-3-(trifluoromethyl)phenyl]amino]-4-(4-pyridinyl)-5-thiazolemethanol (JNJ-1930942), a novel positive allosteric modulator of the {alpha}7 nicotinic acetylcholine receptor.
    Dinklo T; Shaban H; Thuring JW; Lavreysen H; Stevens KE; Zheng L; Mackie C; Grantham C; Vandenberk I; Meulders G; Peeters L; Verachtert H; De Prins E; Lesage AS
    J Pharmacol Exp Ther; 2011 Feb; 336(2):560-74. PubMed ID: 21084390
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis and nicotinic receptor activity of chemical space analogues of N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide (PNU-282,987) and 1,4-diazabicyclo[3.2.2]nonane-4-carboxylic acid 4-bromophenyl ester (SSR180711).
    Bréthous L; Garcia-Delgado N; Schwartz J; Bertrand S; Bertrand D; Reymond JL
    J Med Chem; 2012 May; 55(10):4605-18. PubMed ID: 22591063
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Novel α3β4 nicotinic acetylcholine receptor-selective ligands. Discovery, structure-activity studies, and pharmacological evaluation.
    Zaveri N; Jiang F; Olsen C; Polgar W; Toll L
    J Med Chem; 2010 Nov; 53(22):8187-91. PubMed ID: 20979364
    [TBL] [Abstract][Full Text] [Related]  

  • 10. In vitro pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107.
    Malysz J; Anderson DJ; Grønlien JH; Ji J; Bunnelle WH; Håkerud M; Thorin-Hagene K; Ween H; Helfrich R; Hu M; Gubbins E; Gopalakrishnan S; Puttfarcken PS; Briggs CA; Li J; Meyer MD; Dyhring T; Ahring PK; Nielsen EØ; Peters D; Timmermann DB; Gopalakrishnan M
    J Pharmacol Exp Ther; 2010 Sep; 334(3):863-74. PubMed ID: 20504915
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis of two fluoro analogues of the nicotinic acetylcholine receptor agonist UB-165.
    Sutherland A; Gallagher T; Sharples CG; Wonnacott S
    J Org Chem; 2003 Mar; 68(6):2475-8. PubMed ID: 12636420
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Importance of M2-M3 loop in governing properties of genistein at the α7 nicotinic acetylcholine receptor inferred from α7/5-HT3A chimera.
    Grønlien JH; Ween H; Thorin-Hagene K; Cassar S; Li J; Briggs CA; Gopalakrishnan M; Malysz J
    Eur J Pharmacol; 2010 Nov; 647(1-3):37-47. PubMed ID: 20816816
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis and pharmacological characterization of exo-2-(2'-chloro-5-pyridinyl)-7-(endo and exo)-aminobicyclo[2.2.1]heptanes as novel epibatidine analogues.
    Carroll FI; Brieaddy LE; Navarro HA; Damaj MI; Martin BR
    J Med Chem; 2005 Nov; 48(23):7491-5. PubMed ID: 16279810
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Discovery of the alpha7 nicotinic acetylcholine receptor agonists. (R)-3'-(5-Chlorothiophen-2-yl)spiro-1-azabicyclo[2.2.2]octane-3,5'-[1',3']oxazolidin-2'-one as a novel, potent, selective, and orally bioavailable ligand.
    Tatsumi R; Fujio M; Satoh H; Katayama J; Takanashi S; Hashimoto K; Tanaka H
    J Med Chem; 2005 Apr; 48(7):2678-86. PubMed ID: 15801858
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Epibatidine structure-activity relationships.
    Carroll FI
    Bioorg Med Chem Lett; 2004 Apr; 14(8):1889-96. PubMed ID: 15050621
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Brainstem cholinergic pathways diminish cardiovascular and neuroinflammatory actions of endotoxemia in rats: Role of NFκB/α7/α4β2AChRs signaling.
    Sallam MY; El-Gowilly SM; Fouda MA; Abd-Alhaseeb MM; El-Mas MM
    Neuropharmacology; 2019 Oct; 157():107683. PubMed ID: 31247270
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Pharmacological and behavioral profile of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-6-chinolincarboxamide (EVP-5141), a novel α7 nicotinic acetylcholine receptor agonist/serotonin 5-HT3 receptor antagonist.
    Boess FG; de Vry J; Erb C; Flessner T; Hendrix M; Luithle J; Methfessel C; Schnizler K; van der Staay FJ; van Kampen M; Wiese WB; König G
    Psychopharmacology (Berl); 2013 May; 227(1):1-17. PubMed ID: 23241647
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Distinct profiles of alpha7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes.
    Grønlien JH; Håkerud M; Ween H; Thorin-Hagene K; Briggs CA; Gopalakrishnan M; Malysz J
    Mol Pharmacol; 2007 Sep; 72(3):715-24. PubMed ID: 17565004
    [TBL] [Abstract][Full Text] [Related]  

  • 19. (+)-3-[2-(Benzo[b]thiophen-2-yl)-2-oxoethyl]-1-azabicyclo[2.2.2]octane as potent agonists for the alpha7 nicotinic acetylcholine receptor.
    Tatsumi R; Seio K; Fujio M; Katayama J; Horikawa T; Hashimoto K; Tanaka H
    Bioorg Med Chem Lett; 2004 Jul; 14(14):3781-4. PubMed ID: 15203161
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Alpha-7 nicotinic acetylcholine receptor agonists selectively activate limbic regions of the rat forebrain: an effect similar to antipsychotics.
    Hansen HH; Timmermann DB; Peters D; Walters C; Damaj MI; Mikkelsen JD
    J Neurosci Res; 2007 Jun; 85(8):1810-8. PubMed ID: 17455307
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.