BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

198 related articles for article (PubMed ID: 18493582)

  • 1. Kinetics and ligand-binding preferences of Mycobacterium tuberculosis thymidylate synthases, ThyA and ThyX.
    Hunter JH; Gujjar R; Pang CK; Rathod PK
    PLoS One; 2008 May; 3(5):e2237. PubMed ID: 18493582
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Mycobacterium tuberculosis thymidylate synthase gene thyX is essential and potentially bifunctional, while thyA deletion confers resistance to p-aminosalicylic acid.
    Fivian-Hughes AS; Houghton J; Davis EO
    Microbiology (Reading); 2012 Feb; 158(Pt 2):308-318. PubMed ID: 22034487
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Discovery of an acyclic nucleoside phosphonate that inhibits Mycobacterium tuberculosis ThyX based on the binding mode of a 5-alkynyl substrate analogue.
    Parchina A; Froeyen M; Margamuljana L; Rozenski J; De Jonghe S; Briers Y; Lavigne R; Herdewijn P; Lescrinier E
    ChemMedChem; 2013 Aug; 8(8):1373-83. PubMed ID: 23836539
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Discovery of a new Mycobacterium tuberculosis thymidylate synthase X inhibitor with a unique inhibition profile.
    Abu El Asrar R; Margamuljana L; Klaassen H; Nijs M; Marchand A; Chaltin P; Myllykallio H; Becker HF; De Jonghe S; Herdewijn P; Lescrinier E
    Biochem Pharmacol; 2017 Jul; 135():69-78. PubMed ID: 28359706
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis and evaluation of C-5 modified 2'-deoxyuridine monophosphates as inhibitors of M. tuberculosis thymidylate synthase.
    Alexandrova LA; Chekhov VO; Shmalenyuk ER; Kochetkov SN; El-Asrar RA; Herdewijn P
    Bioorg Med Chem; 2015 Nov; 23(22):7131-7. PubMed ID: 26482569
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Functional analysis of the Mycobacterium tuberculosis FAD-dependent thymidylate synthase, ThyX, reveals new amino acid residues contributing to an extended ThyX motif.
    Ulmer JE; Boum Y; Thouvenel CD; Myllykallio H; Sibley CH
    J Bacteriol; 2008 Mar; 190(6):2056-64. PubMed ID: 18192395
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Thymidylate synthases of Mycoplasma mycoides subsp. mycoides SC and Ureaplasma parvum are flavin-dependent.
    Wehelie R; Eriksson S; Bölske G; Wang L
    Vet Microbiol; 2010 Oct; 145(3-4):265-72. PubMed ID: 20413228
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis and evaluation of 6-aza-2'-deoxyuridine monophosphate analogs as inhibitors of thymidylate synthases, and as substrates or inhibitors of thymidine monophosphate kinase in Mycobacterium tuberculosis.
    Kögler M; Busson R; De Jonghe S; Rozenski J; Van Belle K; Louat T; Munier-Lehmann H; Herdewijn P
    Chem Biodivers; 2012 Mar; 9(3):536-56. PubMed ID: 22422522
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Virtual Screening and X-ray Crystallography Identify Non-Substrate Analog Inhibitors of Flavin-Dependent Thymidylate Synthase.
    Luciani R; Saxena P; Surade S; Santucci M; Venturelli A; Borsari C; Marverti G; Ponterini G; Ferrari S; Blundell TL; Costi MP
    J Med Chem; 2016 Oct; 59(19):9269-9275. PubMed ID: 27589670
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis and evaluation of 5-substituted 2'-deoxyuridine monophosphate analogues as inhibitors of flavin-dependent thymidylate synthase in Mycobacterium tuberculosis.
    Kögler M; Vanderhoydonck B; De Jonghe S; Rozenski J; Van Belle K; Herman J; Louat T; Parchina A; Sibley C; Lescrinier E; Herdewijn P
    J Med Chem; 2011 Jul; 54(13):4847-62. PubMed ID: 21657202
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Functional analysis of FAD-dependent thymidylate synthase ThyX from Paramecium bursaria Chlorella virus-1.
    Graziani S; Xia Y; Gurnon JR; Van Etten JL; Leduc D; Skouloubris S; Myllykallio H; Liebl U
    J Biol Chem; 2004 Dec; 279(52):54340-7. PubMed ID: 15471872
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Predictive modeling targets thymidylate synthase ThyX in Mycobacterium tuberculosis.
    Djaout K; Singh V; Boum Y; Katawera V; Becker HF; Bush NG; Hearnshaw SJ; Pritchard JE; Bourbon P; Madrid PB; Maxwell A; Mizrahi V; Myllykallio H; Ekins S
    Sci Rep; 2016 Jun; 6():27792. PubMed ID: 27283217
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structure of the Mycobacterium tuberculosis flavin dependent thymidylate synthase (MtbThyX) at 2.0A resolution.
    Sampathkumar P; Turley S; Ulmer JE; Rhie HG; Sibley CH; Hol WG
    J Mol Biol; 2005 Oct; 352(5):1091-104. PubMed ID: 16139296
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Mechanistic and structural basis for inhibition of thymidylate synthase ThyX.
    Basta T; Boum Y; Briffotaux J; Becker HF; Lamarre-Jouenne I; Lambry JC; Skouloubris S; Liebl U; Graille M; van Tilbeurgh H; Myllykallio H
    Open Biol; 2012 Oct; 2(10):120120. PubMed ID: 23155486
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The gene encoding the alternative thymidylate synthase ThyX is regulated by sigma factor SigB in Corynebacterium glutamicum ATCC 13032.
    Cho S; Yang S; Rhie H
    FEMS Microbiol Lett; 2012 Mar; 328(2):157-65. PubMed ID: 22224900
    [TBL] [Abstract][Full Text] [Related]  

  • 16. An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene.
    Koehn EM; Fleischmann T; Conrad JA; Palfey BA; Lesley SA; Mathews II; Kohen A
    Nature; 2009 Apr; 458(7240):919-23. PubMed ID: 19370033
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Flavin-dependent thymidylate synthase ThyX activity: implications for the folate cycle in bacteria.
    Leduc D; Escartin F; Nijhout HF; Reed MC; Liebl U; Skouloubris S; Myllykallio H
    J Bacteriol; 2007 Dec; 189(23):8537-45. PubMed ID: 17890305
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Functional evidence for active site location of tetrameric thymidylate synthase X at the interphase of three monomers.
    Leduc D; Graziani S; Lipowski G; Marchand C; Le Maréchal P; Liebl U; Myllykallio H
    Proc Natl Acad Sci U S A; 2004 May; 101(19):7252-7. PubMed ID: 15123820
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Flavin-dependent thymidylate synthase: a novel pathway towards thymine.
    Koehn EM; Kohen A
    Arch Biochem Biophys; 2010 Jan; 493(1):96-102. PubMed ID: 19643076
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Direct observation of the participation of flavin in product formation by thyX-encoded thymidylate synthase.
    Gattis SG; Palfey BA
    J Am Chem Soc; 2005 Jan; 127(3):832-3. PubMed ID: 15656610
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.