210 related articles for article (PubMed ID: 18496885)
1. Enzymatic stability of 2'-ethylcarbonate-linked paclitaxel in serum and conversion to paclitaxel by rabbit liver carboxylesterase for use in prodrug/enzyme therapy.
Tanino T; Nawa A; Miki Y; Iwaki M
Biopharm Drug Dispos; 2008 Jul; 29(5):259-69. PubMed ID: 18496885
[TBL] [Abstract][Full Text] [Related]
2. Enhanced cytotoxicity with a novel system combining the paclitaxel-2'-ethylcarbonate prodrug and an HSV amplicon with an attenuated replication-competent virus, HF10 as a helper virus.
Ishida D; Nawa A; Tanino T; Goshima F; Luo CH; Iwaki M; Kajiyama H; Shibata K; Yamamoto E; Ino K; Tsurumi T; Nishiyama Y; Kikkawa F
Cancer Lett; 2010 Feb; 288(1):17-27. PubMed ID: 19604626
[TBL] [Abstract][Full Text] [Related]
3. Paclitaxel-2'-Ethylcarbonate prodrug can circumvent P-glycoprotein-mediated cellular efflux to increase drug cytotoxicity.
Tanino T; Nawa A; Kondo E; Kikkawa F; Daikoku T; Tsurumi T; Luo C; Nishiyama Y; Takayanagi Y; Nishimori K; Ichida S; Wada T; Miki Y; Iwaki M
Pharm Res; 2007 Mar; 24(3):555-65. PubMed ID: 17245652
[TBL] [Abstract][Full Text] [Related]
4. Utility of the carboxylesterase inhibitor bis-para-nitrophenylphosphate (BNPP) in the plasma unbound fraction determination for a hydrolytically unstable amide derivative and agonist of the TGR5 receptor.
Eng H; Niosi M; McDonald TS; Wolford A; Chen Y; Simila ST; Bauman JN; Warmus J; Kalgutkar AS
Xenobiotica; 2010 Jun; 40(6):369-80. PubMed ID: 20297923
[TBL] [Abstract][Full Text] [Related]
5. The role of rat serum carboxylesterase in the activation of paclitaxel and camptothecin prodrugs.
Senter PD; Marquardt H; Thomas BA; Hammock BD; Frank IS; Svensson HP
Cancer Res; 1996 Apr; 56(7):1471-4. PubMed ID: 8603386
[TBL] [Abstract][Full Text] [Related]
6. Gene directed enzyme prodrug therapy for ovarian cancer: could GDEPT become a promising treatment against ovarian cancer?
Nawa A; Tanino T; Luo C; Iwaki M; Kajiyama H; Shibata K; Yamamoto E; Ino K; Nishiyama Y; Kikkawa F
Anticancer Agents Med Chem; 2008 Feb; 8(2):232-9. PubMed ID: 18288924
[TBL] [Abstract][Full Text] [Related]
7. Enhanced paclitaxel bioavailability after oral coadministration of paclitaxel prodrug with naringin to rats.
Choi JS; Shin SC
Int J Pharm; 2005 Mar; 292(1-2):149-56. PubMed ID: 15725561
[TBL] [Abstract][Full Text] [Related]
8. Isolation and pharmacological characterization of microsomal human liver flumazenil carboxylesterase.
Kleingeist B; Böcker R; Geisslinger G; Brugger R
J Pharm Pharm Sci; 1998; 1(1):38-46. PubMed ID: 10942971
[TBL] [Abstract][Full Text] [Related]
9. Contribution of carboxylesterase in hamster to the intestinal first-pass loss and low bioavailability of ethyl piperate, an effective lipid-lowering drug candidate.
Lu Y; Bao N; Borjihan G; Ma Y; Hu M; Yu C; Li S; Jia J; Yang D; Wang Y
Drug Metab Dispos; 2011 May; 39(5):796-802. PubMed ID: 21346005
[TBL] [Abstract][Full Text] [Related]
10. Organic anion transporting polypeptide 2-mediated uptake of paclitaxel and 2'-ethylcarbonate-linked paclitaxel in freshly isolated rat hepatocytes.
Tanino T; Nawa A; Nakao M; Noda M; Fujiwara S; Iwaki M
J Pharm Pharmacol; 2009 Aug; 61(8):1029-35. PubMed ID: 19703346
[TBL] [Abstract][Full Text] [Related]
11. In vitro deacetylation studies with isomeric acetamidobiphenyls using selective carboxylesterase inhibitors.
Sertkaya NN; Gorrod JW
Anticancer Res; 1988; 8(6):1345-50. PubMed ID: 3218967
[TBL] [Abstract][Full Text] [Related]
12. Hydrolytic metabolism of pyrethroids by human and other mammalian carboxylesterases.
Ross MK; Borazjani A; Edwards CC; Potter PM
Biochem Pharmacol; 2006 Feb; 71(5):657-69. PubMed ID: 16387282
[TBL] [Abstract][Full Text] [Related]
13. Development of a novel system for estimating human intestinal absorption using Caco-2 cells in the absence of esterase activity.
Ohura K; Sakamoto H; Ninomiya S; Imai T
Drug Metab Dispos; 2010 Feb; 38(2):323-31. PubMed ID: 19923255
[TBL] [Abstract][Full Text] [Related]
14. Species differences in the in vitro metabolism of deltamethrin and esfenvalerate: differential oxidative and hydrolytic metabolism by humans and rats.
Godin SJ; Scollon EJ; Hughes MF; Potter PM; DeVito MJ; Ross MK
Drug Metab Dispos; 2006 Oct; 34(10):1764-71. PubMed ID: 16855054
[TBL] [Abstract][Full Text] [Related]
15. Conclusive identification of the oxybutynin-hydrolyzing enzyme in human liver.
Sato Y; Miyashita A; Iwatsubo T; Usui T
Drug Metab Dispos; 2012 May; 40(5):902-6. PubMed ID: 22293119
[TBL] [Abstract][Full Text] [Related]
16. The in vitro metabolism of a pyrethroid insecticide, permethrin, and its hydrolysis products in rats.
Nakamura Y; Sugihara K; Sone T; Isobe M; Ohta S; Kitamura S
Toxicology; 2007 Jun; 235(3):176-84. PubMed ID: 17451859
[TBL] [Abstract][Full Text] [Related]
17. Characterization of esterases involved in the stereoselective hydrolysis of ester-type prodrugs of propranolol in rat liver and plasma.
Yoshigae Y; Imai T; Taketani M; Otagiri M
Chirality; 1999; 11(1):10-3. PubMed ID: 9914648
[TBL] [Abstract][Full Text] [Related]
18. Dexamethasone-induced methylprednisolone hemisuccinate hydrolase: its identification as a member of the rat carboxylesterase 2 family and its unique existence in plasma.
Furihata T; Hosokawa M; Fujii A; Derbel M; Satoh T; Chiba K
Biochem Pharmacol; 2005 Apr; 69(8):1287-97. PubMed ID: 15794950
[TBL] [Abstract][Full Text] [Related]
19. Evidence for the involvement of a pulmonary first-pass effect via carboxylesterase in the disposition of a propranolol ester derivative after intravenous administration.
Imai T; Yoshigae Y; Hosokawa M; Chiba K; Otagiri M
J Pharmacol Exp Ther; 2003 Dec; 307(3):1234-42. PubMed ID: 14534358
[TBL] [Abstract][Full Text] [Related]
20. Involvement of human blood arylesterases and liver microsomal carboxylesterases in nafamostat hydrolysis.
Yamaori S; Fujiyama N; Kushihara M; Funahashi T; Kimura T; Yamamoto I; Sone T; Isobe M; Ohshima T; Matsumura K; Oda M; Watanabe K
Drug Metab Pharmacokinet; 2006 Apr; 21(2):147-55. PubMed ID: 16702735
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]