BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

84 related articles for article (PubMed ID: 18502756)

  • 1. Glu(332) in the Nicastrin ectodomain is essential for gamma-secretase complex maturation but not for its activity.
    Chávez-Gutiérrez L; Tolia A; Maes E; Li T; Wong PC; de Strooper B
    J Biol Chem; 2008 Jul; 283(29):20096-105. PubMed ID: 18502756
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Formation of Pmel17 amyloid is regulated by juxtamembrane metalloproteinase cleavage, and the resulting C-terminal fragment is a substrate for gamma-secretase.
    Kummer MP; Maruyama H; Huelsmann C; Baches S; Weggen S; Koo EH
    J Biol Chem; 2009 Jan; 284(4):2296-306. PubMed ID: 19047044
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The cryo-electron microscopy structure of γ-Secretase: towards complex assembly, substrate recognition and a catalytic mechanism.
    Kang Y; Melcher K; Xu HE
    Natl Sci Rev; 2015 Mar; 2(1):4-5. PubMed ID: 26090270
    [No Abstract]   [Full Text] [Related]  

  • 4. The γ-secretase complex: from structure to function.
    Zhang X; Li Y; Xu H; Zhang YW
    Front Cell Neurosci; 2014; 8():427. PubMed ID: 25565961
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Functional and topological analysis of Pen-2, the fourth subunit of the gamma-secretase complex.
    Bammens L; Chávez-Gutiérrez L; Tolia A; Zwijsen A; De Strooper B
    J Biol Chem; 2011 Apr; 286(14):12271-82. PubMed ID: 21296884
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Enzyme-substrate interface targeting by imidazole-based γ-secretase modulators activates γ-secretase and stabilizes its interaction with APP.
    Petit D; Hitzenberger M; Koch M; Lismont S; Zoltowska KM; Enzlein T; Hopf C; Zacharias M; Chávez-Gutiérrez L
    EMBO J; 2022 Nov; 41(21):e111084. PubMed ID: 36121025
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The Genomic Architecture of Hidradenitis Suppurativa-A Systematic Review.
    Pace NP; Mintoff D; Borg I
    Front Genet; 2022; 13():861241. PubMed ID: 35401657
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Revisiting APP secretases: an overview on the holistic effects of retinoic acid receptor stimulation in APP processing.
    Vitória JJM; Trigo D; da Cruz E Silva OAB
    Cell Mol Life Sci; 2022 Jan; 79(2):101. PubMed ID: 35089425
    [TBL] [Abstract][Full Text] [Related]  

  • 9. TrkA-mediated endocytosis of p75-CTF prevents cholinergic neuron death upon γ-secretase inhibition.
    Franco ML; García-Carpio I; Comaposada-Baró R; Escribano-Saiz JJ; Chávez-Gutiérrez L; Vilar M
    Life Sci Alliance; 2021 Apr; 4(4):. PubMed ID: 33536237
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Super-resolution microscopy reveals majorly mono- and dimeric presenilin1/γ-secretase at the cell surface.
    Escamilla-Ayala AA; Sannerud R; Mondin M; Poersch K; Vermeire W; Paparelli L; Berlage C; Koenig M; Chavez-Gutierrez L; Ulbrich MH; Munck S; Mizuno H; Annaert W
    Elife; 2020 Jul; 9():. PubMed ID: 32631487
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Making the final cut: pathogenic amyloid-β peptide generation by γ-secretase.
    Steiner H; Fukumori A; Tagami S; Okochi M
    Cell Stress; 2018 Oct; 2(11):292-310. PubMed ID: 31225454
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structure and Function of the γ-Secretase Complex.
    Wolfe MS
    Biochemistry; 2019 Jul; 58(27):2953-2966. PubMed ID: 31198028
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Extracellular interface between APP and Nicastrin regulates Aβ length and response to γ-secretase modulators.
    Petit D; Hitzenberger M; Lismont S; Zoltowska KM; Ryan NS; Mercken M; Bischoff F; Zacharias M; Chávez-Gutiérrez L
    EMBO J; 2019 Jun; 38(12):. PubMed ID: 31109937
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP.
    Wiseman FK; Pulford LJ; Barkus C; Liao F; Portelius E; Webb R; Chávez-Gutiérrez L; Cleverley K; Noy S; Sheppard O; Collins T; Powell C; Sarell CJ; Rickman M; Choong X; Tosh JL; Siganporia C; Whittaker HT; Stewart F; Szaruga M; ; Murphy MP; Blennow K; de Strooper B; Zetterberg H; Bannerman D; Holtzman DM; Tybulewicz VLJ; Fisher EMC;
    Brain; 2018 Aug; 141(8):2457-2474. PubMed ID: 29945247
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Allosteric Modulation of Intact γ-Secretase Structural Dynamics.
    Lee JY; Feng Z; Xie XQ; Bahar I
    Biophys J; 2017 Dec; 113(12):2634-2649. PubMed ID: 29262358
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Characterizing the structural ensemble of γ-secretase using a multiscale molecular dynamics approach.
    Aguayo-Ortiz R; Chávez-García C; Straub JE; Dominguez L
    Chem Sci; 2017 Aug; 8(8):5576-5584. PubMed ID: 28970936
    [TBL] [Abstract][Full Text] [Related]  

  • 17. High-efficient production and biophysical characterisation of nicastrin and its interaction with APPC100.
    Yu K; Yang G; Labahn J
    Sci Rep; 2017 Mar; 7():44297. PubMed ID: 28276527
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Pen-2 and Presenilin are Sufficient to Catalyze Notch Processing.
    Hu C; Xu J; Zeng L; Li T; Cui MZ; Xu X
    J Alzheimers Dis; 2017; 56(4):1263-1269. PubMed ID: 28234257
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Probing γ-secretase-substrate interactions at the single amino acid residue level.
    Chávez-Gutiérrez L; De Strooper B
    EMBO J; 2016 Aug; 35(15):1597-9. PubMed ID: 27370209
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Substrate recruitment of γ-secretase and mechanism of clinical presenilin mutations revealed by photoaffinity mapping.
    Fukumori A; Steiner H
    EMBO J; 2016 Aug; 35(15):1628-43. PubMed ID: 27220847
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 5.