133 related articles for article (PubMed ID: 18502788)
1. Mutation analysis in UGT1A9 suggests a relationship between substrate and catalytic residues in UDP-glucuronosyltransferases.
Patana AS; Kurkela M; Finel M; Goldman A
Protein Eng Des Sel; 2008 Sep; 21(9):537-43. PubMed ID: 18502788
[TBL] [Abstract][Full Text] [Related]
2. The human UDP-glucuronosyltransferase: identification of key residues within the nucleotide-sugar binding site.
Patana AS; Kurkela M; Goldman A; Finel M
Mol Pharmacol; 2007 Sep; 72(3):604-11. PubMed ID: 17578897
[TBL] [Abstract][Full Text] [Related]
3. Influence of N-terminal domain histidine and proline residues on the substrate selectivities of human UDP-glucuronosyltransferase 1A1, 1A6, 1A9, 2B7, and 2B10.
Kerdpin O; Mackenzie PI; Bowalgaha K; Finel M; Miners JO
Drug Metab Dispos; 2009 Sep; 37(9):1948-55. PubMed ID: 19487247
[TBL] [Abstract][Full Text] [Related]
4. How many and which amino acids are responsible for the large activity differences between the highly homologous UDP-glucuronosyltransferases (UGT) 1A9 and UGT1A10?
Itäaho K; Laakkonen L; Finel M
Drug Metab Dispos; 2010 Apr; 38(4):687-96. PubMed ID: 20089735
[TBL] [Abstract][Full Text] [Related]
5. Identification of aspartic acid and histidine residues mediating the reaction mechanism and the substrate specificity of the human UDP-glucuronosyltransferases 1A.
Li D; Fournel-Gigleux S; Barré L; Mulliert G; Netter P; Magdalou J; Ouzzine M
J Biol Chem; 2007 Dec; 282(50):36514-24. PubMed ID: 17956868
[TBL] [Abstract][Full Text] [Related]
6. Structural and functional studies of UDP-glucuronosyltransferases.
Radominska-Pandya A; Czernik PJ; Little JM; Battaglia E; Mackenzie PI
Drug Metab Rev; 1999 Nov; 31(4):817-99. PubMed ID: 10575553
[TBL] [Abstract][Full Text] [Related]
7. Key amino acid residues responsible for the differences in substrate specificity of human UDP-glucuronosyltransferase (UGT)1A9 and UGT1A8.
Fujiwara R; Nakajima M; Yamanaka H; Yokoi T
Drug Metab Dispos; 2009 Jan; 37(1):41-6. PubMed ID: 18832479
[TBL] [Abstract][Full Text] [Related]
8. Effects of amino acid substitutions at positions 33 and 37 on UDP-glucuronosyltransferase 1A9 (UGT1A9) activity and substrate selectivity.
Korprasertthaworn P; Rowland A; Lewis BC; Mackenzie PI; Yoovathaworn K; Miners JO
Biochem Pharmacol; 2012 Dec; 84(11):1511-21. PubMed ID: 22981363
[TBL] [Abstract][Full Text] [Related]
9. Phylogenetic and mutational analyses reveal key residues for UDP-glucuronic acid binding and activity of beta1,3-glucuronosyltransferase I (GlcAT-I).
Fondeur-Gelinotte M; Lattard V; Oriol R; Mollicone R; Jacquinet JC; Mulliert G; Gulberti S; Netter P; Magdalou J; Ouzzine M; Fournel-Gigleux S
Protein Sci; 2006 Jul; 15(7):1667-78. PubMed ID: 16815917
[TBL] [Abstract][Full Text] [Related]
10. The configuration of the 17-hydroxy group variably influences the glucuronidation of beta-estradiol and epiestradiol by human UDP-glucuronosyltransferases.
Itäaho K; Mackenzie PI; Ikushiro S; Miners JO; Finel M
Drug Metab Dispos; 2008 Nov; 36(11):2307-15. PubMed ID: 18719240
[TBL] [Abstract][Full Text] [Related]
11. The first aspartic acid of the DQxD motif for human UDP-glucuronosyltransferase 1A10 interacts with UDP-glucuronic acid during catalysis.
Xiong Y; Patana AS; Miley MJ; Zielinska AK; Bratton SM; Miller GP; Goldman A; Finel M; Redinbo MR; Radominska-Pandya A
Drug Metab Dispos; 2008 Mar; 36(3):517-22. PubMed ID: 18048489
[TBL] [Abstract][Full Text] [Related]
12. The donor substrate specificity of the human beta 1,3-glucuronosyltransferase I toward UDP-glucuronic acid is determined by two crucial histidine and arginine residues.
Ouzzine M; Gulberti S; Levoin N; Netter P; Magdalou J; Fournel-Gigleux S
J Biol Chem; 2002 Jul; 277(28):25439-45. PubMed ID: 11986319
[TBL] [Abstract][Full Text] [Related]
13. Nicotine glucuronidation and the human UDP-glucuronosyltransferase UGT2B10.
Kaivosaari S; Toivonen P; Hesse LM; Koskinen M; Court MH; Finel M
Mol Pharmacol; 2007 Sep; 72(3):761-8. PubMed ID: 17576790
[TBL] [Abstract][Full Text] [Related]
14. An active and water-soluble truncation mutant of the human UDP-glucuronosyltransferase 1A9.
Kurkela M; Mörsky S; Hirvonen J; Kostiainen R; Finel M
Mol Pharmacol; 2004 Apr; 65(4):826-31. PubMed ID: 15044611
[TBL] [Abstract][Full Text] [Related]
15. Catalytic key amino acids and UDP-sugar donor specificity of a plant glucuronosyltransferase, UGT94B1: molecular modeling substantiated by site-specific mutagenesis and biochemical analyses.
Osmani SA; Bak S; Imberty A; Olsen CE; Møller BL
Plant Physiol; 2008 Nov; 148(3):1295-308. PubMed ID: 18829982
[TBL] [Abstract][Full Text] [Related]
16. Insights on membrane topology and structure/function of UDP-glucuronosyltransferases.
Magdalou J; Fournel-Gigleux S; Ouzzine M
Drug Metab Rev; 2010 Feb; 42(1):159-66. PubMed ID: 19807219
[TBL] [Abstract][Full Text] [Related]
17. Photoaffinity labeling studies of the human recombinant UDP-glucuronosyltransferase, UGT1*6, with 5-azido-UDP-glucuronic acid.
Battaglia E; Nowell S; Drake RR; Magdalou J; Fournel-Gigleux S; Senay C; Radominska A
Drug Metab Dispos; 1997 Apr; 25(4):406-11. PubMed ID: 9107538
[TBL] [Abstract][Full Text] [Related]
18. UDP-glucuronic acid binds first and the aglycone substrate binds second to form a ternary complex in UGT1A9-catalyzed reactions, in both the presence and absence of bovine serum albumin.
Manevski N; Yli-Kauhaluoma J; Finel M
Drug Metab Dispos; 2012 Nov; 40(11):2192-203. PubMed ID: 22912433
[TBL] [Abstract][Full Text] [Related]
19. Critical roles of residues 36 and 40 in the phenol and tertiary amine aglycone substrate selectivities of UDP-glucuronosyltransferases 1A3 and 1A4.
Kubota T; Lewis BC; Elliot DJ; Mackenzie PI; Miners JO
Mol Pharmacol; 2007 Oct; 72(4):1054-62. PubMed ID: 17636046
[TBL] [Abstract][Full Text] [Related]
20. N-Glycosylation plays a role in protein folding of human UGT1A9.
Nakajima M; Koga T; Sakai H; Yamanaka H; Fujiwara R; Yokoi T
Biochem Pharmacol; 2010 Apr; 79(8):1165-72. PubMed ID: 19951703
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
