142 related articles for article (PubMed ID: 18506361)
1. Induction of tumor cell apoptosis by a novel class of N-thiolated beta-lactam antibiotics with structural modifications at N1 and C3 of the lactam ring.
Frezza M; Garay J; Chen D; Cui C; Turos E; Dou QP
Int J Mol Med; 2008 Jun; 21(6):689-95. PubMed ID: 18506361
[TBL] [Abstract][Full Text] [Related]
2. Structure-activity relationships OF N-methylthiolated beta-lactam antibiotics with C3 substitutions and their selective induction of apoptosis in human cancer cells.
Kuhn DJ; Wang Y; Minic V; Coates C; Reddy GS; Daniel KG; Shim JY; Chen D; Landis-Piwowar KR; Miller FR; Turos E; Dou QP
Front Biosci; 2005 May; 10():1183-90. PubMed ID: 15769617
[TBL] [Abstract][Full Text] [Related]
3. Novel N-thiolated beta-lactam antibiotics selectively induce apoptosis in human tumor and transformed, but not normal or nontransformed, cells.
Kazi A; Hill R; Long TE; Kuhn DJ; Turos E; Dou QP
Biochem Pharmacol; 2004 Jan; 67(2):365-74. PubMed ID: 14698048
[TBL] [Abstract][Full Text] [Related]
4. Anti-tumor activity of N-thiolated beta-lactam antibiotics.
Chen D; Falsetti SC; Frezza M; Milacic V; Kazi A; Cui QC; Long TE; Turos E; Dou QP
Cancer Lett; 2008 Sep; 268(1):63-9. PubMed ID: 18468785
[TBL] [Abstract][Full Text] [Related]
5. A novel beta-lactam antibiotic activates tumor cell apoptotic program by inducing DNA damage.
Smith DM; Kazi A; Smith L; Long TE; Heldreth B; Turos E; Dou QP
Mol Pharmacol; 2002 Jun; 61(6):1348-58. PubMed ID: 12021396
[TBL] [Abstract][Full Text] [Related]
6. Beta-lactams and their potential use as novel anticancer chemotherapeutics drugs.
Kuhn D; Coates C; Daniel K; Chen D; Bhuiyan M; Kazi A; Turos E; Dou QP
Front Biosci; 2004 Sep; 9():2605-17. PubMed ID: 15358584
[TBL] [Abstract][Full Text] [Related]
7. β-Lactams as promising anticancer agents: Molecular hybrids, structure activity relationships and potential targets.
Fu DJ; Zhang YF; Chang AQ; Li J
Eur J Med Chem; 2020 Sep; 201():112510. PubMed ID: 32592915
[TBL] [Abstract][Full Text] [Related]
8. Structure-Activity Relationship Studies of β-Lactam-azide Analogues as Orally Active Antitumor Agents Targeting the Tubulin Colchicine Site.
Fu DJ; Fu L; Liu YC; Wang JW; Wang YQ; Han BK; Li XR; Zhang C; Li F; Song J; Zhao B; Mao RW; Zhao RH; Zhang SY; Zhang L; Zhang YB; Liu HM
Sci Rep; 2017 Oct; 7(1):12788. PubMed ID: 28986548
[TBL] [Abstract][Full Text] [Related]
9. Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral β-lactam bridged combretastatin A-4 analogues as potent antitumor agents.
Zhou P; Liang Y; Zhang H; Jiang H; Feng K; Xu P; Wang J; Wang X; Ding K; Luo C; Liu M; Wang Y
Eur J Med Chem; 2018 Jan; 144():817-842. PubMed ID: 29306206
[TBL] [Abstract][Full Text] [Related]
10. Beta-lactam type molecular scaffolds for antiproliferative activity: synthesis and cytotoxic effects in breast cancer cells.
Meegan MJ; Carr M; Knox AJ; Zisterer DM; Lloyd DG
J Enzyme Inhib Med Chem; 2008 Oct; 23(5):668-85. PubMed ID: 18821256
[TBL] [Abstract][Full Text] [Related]
11. Poly (ADP-ribose) polymerase inhibition enhances trastuzumab antitumour activity in HER2 overexpressing breast cancer.
García-Parra J; Dalmases A; Morancho B; Arpí O; Menendez S; Sabbaghi M; Zazo S; Chamizo C; Madoz J; Eroles P; Servitja S; Tusquets I; Yelamos J; Lluch A; Arribas J; Rojo F; Rovira A; Albanell J
Eur J Cancer; 2014 Oct; 50(15):2725-34. PubMed ID: 25128455
[TBL] [Abstract][Full Text] [Related]
12. Optically active 1,3,4,4-tetrasubstituted β-lactams: synthesis and evaluation as tumor cell growth inhibitors.
Pérez-Faginas P; Aranda MT; García-López MT; Francesch A; Cuevas C; González-Muñiz R
Eur J Med Chem; 2011 Oct; 46(10):5108-19. PubMed ID: 21885166
[TBL] [Abstract][Full Text] [Related]
13. Effective targeting of triple-negative breast cancer cells by PF-4942847, a novel oral inhibitor of Hsp 90.
Mehta PP; Whalen P; Baxi SM; Kung PP; Yamazaki S; Yin MJ
Clin Cancer Res; 2011 Aug; 17(16):5432-42. PubMed ID: 21715568
[TBL] [Abstract][Full Text] [Related]
14. Poly (ADP-ribose) polymerases inhibitor, Zj6413, as a potential therapeutic agent against breast cancer.
Zhou Q; Ji M; Zhou J; Jin J; Xue N; Chen J; Xu B; Chen X
Biochem Pharmacol; 2016 May; 107():29-40. PubMed ID: 26920250
[TBL] [Abstract][Full Text] [Related]
15. Targeting on poly(ADP-ribose) polymerase activity with DNA-damaging hybrid lactam-steroid alkylators in wild-type and BRCA1-mutated ovarian cancer cells.
Trafalis DT; Polonifi A; Dalezis P; Nikoleousakos N; Katsamakas S; Sarli V
Chem Biol Drug Des; 2017 Nov; 90(5):854-866. PubMed ID: 28432813
[TBL] [Abstract][Full Text] [Related]
16. N-Methylthio beta-lactam antibacterials: effects of the C3/C4 ring substituents on anti-MRSA activity.
Turos E; Coates C; Shim JY; Wang Y; Leslie JM; Long TE; Reddy GS; Ortiz A; Culbreath M; Dickey S; Lim DV; Alonso E; Gonzalez J
Bioorg Med Chem; 2005 Dec; 13(23):6289-308. PubMed ID: 16185880
[TBL] [Abstract][Full Text] [Related]
17. C4-Phenylthio β-lactams: Effect of the chirality of the β-lactam ring on antimicrobial activity.
Kuskovsky R; Lloyd D; Arora K; Plotkin BJ; Green JM; Boshoff HI; Barry C; Deschamps J; Konaklieva MI
Bioorg Med Chem; 2019 Oct; 27(20):115050. PubMed ID: 31474471
[TBL] [Abstract][Full Text] [Related]
18. Synthesis, Cytotoxicity and Antimicrobial Evaluation of New Coumarin-Tagged β-Lactam Triazole Hybrid.
Dhawan S; Awolade P; Kisten P; Cele N; Pillay AS; Saha S; Kaur M; Jonnalagadda SB; Singh P
Chem Biodivers; 2020 Jan; 17(1):e1900462. PubMed ID: 31788939
[TBL] [Abstract][Full Text] [Related]
19. Novel (±)-
Jurin M; Stepanić V; Bojanić K; Vadlja D; Kontrec D; Dražić T; Roje M
Acta Pharm; 2024 Mar; 74(1):37-59. PubMed ID: 38554382
[TBL] [Abstract][Full Text] [Related]
20. The vascular targeting agent combretastatin-A4 and a novel cis-Restricted {beta}-Lactam Analogue, CA-432, induce apoptosis in human chronic myeloid leukemia cells and ex vivo patient samples including those displaying multidrug resistance.
Greene LM; Nathwani SM; Bright SA; Fayne D; Croke A; Gagliardi M; McElligott AM; O'Connor L; Carr M; Keely NO; O'Boyle NM; Carroll P; Sarkadi B; Conneally E; Lloyd DG; Lawler M; Meegan MJ; Zisterer DM
J Pharmacol Exp Ther; 2010 Nov; 335(2):302-13. PubMed ID: 20699436
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
