These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

96 related articles for article (PubMed ID: 18508880)

  • 1. Covalent binding and tissue distribution/retention assessment of drugs associated with idiosyncratic drug toxicity.
    Takakusa H; Masumoto H; Yukinaga H; Makino C; Nakayama S; Okazaki O; Sudo K
    Drug Metab Dispos; 2008 Sep; 36(9):1770-9. PubMed ID: 18508880
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A zone classification system for risk assessment of idiosyncratic drug toxicity using daily dose and covalent binding.
    Nakayama S; Atsumi R; Takakusa H; Kobayashi Y; Kurihara A; Nagai Y; Nakai D; Okazaki O
    Drug Metab Dispos; 2009 Sep; 37(9):1970-7. PubMed ID: 19487250
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The role of leukocyte-generated reactive metabolites in the pathogenesis of idiosyncratic drug reactions.
    Uetrecht JP
    Drug Metab Rev; 1992; 24(3):299-366. PubMed ID: 1628536
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Prediction of in vivo potential for metabolic activation of drugs into chemically reactive intermediate: correlation of in vitro and in vivo generation of reactive intermediates and in vitro glutathione conjugate formation in rats and humans.
    Masubuchi N; Makino C; Murayama N
    Chem Res Toxicol; 2007 Mar; 20(3):455-64. PubMed ID: 17309281
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Cytochrome P450 11A1 bioactivation of a kinase inhibitor in rats: use of radioprofiling, modulation of metabolism, and adrenocortical cell lines to evaluate adrenal toxicity.
    Zhang D; Flint O; Wang L; Gupta A; Westhouse RA; Zhao W; Raghavan N; Caceres-Cortes J; Marathe P; Shen G; Zhang Y; Allentoff A; Josephs J; Gan J; Borzilleri R; Humphreys WG
    Chem Res Toxicol; 2012 Mar; 25(3):556-71. PubMed ID: 22295996
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Protein covalent binding of maxipost through a cytochrome P450-mediated ortho-quinone methide intermediate in rats.
    Zhang D; Ogan M; Gedamke R; Roongta V; Dai R; Zhu M; Rinehart JK; Klunk L; Mitroka J
    Drug Metab Dispos; 2003 Jul; 31(7):837-45. PubMed ID: 12814959
    [TBL] [Abstract][Full Text] [Related]  

  • 7. An integrated reactive metabolite evaluation approach to assess and reduce safety risk during drug discovery and development.
    Reese M; Sakatis M; Ambroso J; Harrell A; Yang E; Chen L; Taylor M; Baines I; Zhu L; Ayrton A; Clarke S
    Chem Biol Interact; 2011 Jun; 192(1-2):60-4. PubMed ID: 20970409
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Bioactivation of coumarin in rat olfactory mucosal microsomes: Detection of protein covalent binding and identification of reactive intermediates through analysis of glutathione adducts.
    Zhuo X; Zhao W; Zheng J; Humphreys WG; Shu YZ; Zhu M
    Chem Biol Interact; 2009 Oct; 181(2):227-35. PubMed ID: 19576871
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Retention mechanism of imidazoles in connective tissue. I. Binding to elastin.
    Ohta K; Yamaguchi JI; Akimoto M; Fukushima K; Suwa T; Awazu S
    Drug Metab Dispos; 1996 Dec; 24(12):1291-7. PubMed ID: 8971133
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The role of P-glycoprotein in the bioactivation of raloxifene.
    Chang JH; Kochansky CJ; Shou M
    Drug Metab Dispos; 2006 Dec; 34(12):2073-8. PubMed ID: 16959878
    [TBL] [Abstract][Full Text] [Related]  

  • 11. [The covalent binding of a potent beta-receptor blocker (B 24/76) on tissue proteins and collagen in the rat].
    Baumann A; Möritz KU
    Pharmazie; 1991 Sep; 46(9):655-7. PubMed ID: 1686806
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Role of benoxaprofen and flunoxaprofen acyl glucuronides in covalent binding to rat plasma and liver proteins in vivo.
    Dong JQ; Liu J; Smith PC
    Biochem Pharmacol; 2005 Sep; 70(6):937-48. PubMed ID: 16046212
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Ethyl methanesulfonate toxicity in Viracept--a comprehensive human risk assessment based on threshold data for genotoxicity.
    Müller L; Gocke E; Lavé T; Pfister T
    Toxicol Lett; 2009 Nov; 190(3):317-29. PubMed ID: 19443141
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Mechanism for covalent binding of rofecoxib to elastin of rat aorta.
    Oitate M; Hirota T; Takahashi M; Murai T; Miura S; Senoo A; Hosokawa T; Oonishi T; Ikeda T
    J Pharmacol Exp Ther; 2007 Mar; 320(3):1195-203. PubMed ID: 17164475
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Final report of the safety assessment of Alcohol Denat., including SD Alcohol 3-A, SD Alcohol 30, SD Alcohol 39, SD Alcohol 39-B, SD Alcohol 39-C, SD Alcohol 40, SD Alcohol 40-B, and SD Alcohol 40-C, and the denaturants, Quassin, Brucine Sulfate/Brucine, and Denatonium Benzoate.
    Cosmetic Ingredient Review Expert Panel
    Int J Toxicol; 2008; 27 Suppl 1():1-43. PubMed ID: 18569160
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Haloacetonitriles: metabolism and toxicity.
    Lipscomb JC; El-Demerdash E; Ahmed AE
    Rev Environ Contam Toxicol; 2009; 198():169-200. PubMed ID: 19253036
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Screening for reactive intermediates and toxicity assessment in drug discovery.
    Caldwell GW; Yan Z
    Curr Opin Drug Discov Devel; 2006 Jan; 9(1):47-60. PubMed ID: 16445117
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Subcellular distribution and metabolism studies of the potential myocardial imaging agent [99mTc(N)(DBODC)(PNP5)]+.
    Bolzati C; Cavazza-Ceccato M; Agostini S; Tokunaga S; Casara D; Bandoli G
    J Nucl Med; 2008 Aug; 49(8):1336-44. PubMed ID: 18632814
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Benchmarking in vitro covalent binding burden as a tool to assess potential toxicity caused by nonspecific covalent binding of covalent drugs.
    Dahal UP; Obach RS; Gilbert AM
    Chem Res Toxicol; 2013 Nov; 26(11):1739-45. PubMed ID: 24164572
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Biodistribution and plasma protein binding of zoledronic acid.
    Weiss HM; Pfaar U; Schweitzer A; Wiegand H; Skerjanec A; Schran H
    Drug Metab Dispos; 2008 Oct; 36(10):2043-9. PubMed ID: 18625688
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 5.