BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

291 related articles for article (PubMed ID: 18520051)

  • 1. Effects of phosphorylation of immunomodulatory agent FTY720 (fingolimod) on antiproliferative activity against breast and colon cancer cells.
    Nagaoka Y; Otsuki K; Fujita T; Uesato S
    Biol Pharm Bull; 2008 Jun; 31(6):1177-81. PubMed ID: 18520051
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Functional characterization of sphingosine 1-phosphate receptor agonist in human endothelial cells.
    Butler J; Lana D; Round O; LaMontagne K
    Prostaglandins Other Lipid Mediat; 2004 Jan; 73(1-2):29-45. PubMed ID: 15165029
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability.
    Sanchez T; Estrada-Hernandez T; Paik JH; Wu MT; Venkataraman K; Brinkmann V; Claffey K; Hla T
    J Biol Chem; 2003 Nov; 278(47):47281-90. PubMed ID: 12954648
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The immunomodulator FTY720 and its phosphorylated derivative activate the Smad signalling cascade and upregulate connective tissue growth factor and collagen type IV expression in renal mesangial cells.
    Xin C; Ren S; Eberhardt W; Pfeilschifter J; Huwiler A
    Br J Pharmacol; 2006 Jan; 147(2):164-74. PubMed ID: 16299553
    [TBL] [Abstract][Full Text] [Related]  

  • 5. FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells.
    Tonelli F; Lim KG; Loveridge C; Long J; Pitson SM; Tigyi G; Bittman R; Pyne S; Pyne NJ
    Cell Signal; 2010 Oct; 22(10):1536-42. PubMed ID: 20570726
    [TBL] [Abstract][Full Text] [Related]  

  • 6. FTY720 analogues as sphingosine kinase 1 inhibitors: enzyme inhibition kinetics, allosterism, proteasomal degradation, and actin rearrangement in MCF-7 breast cancer cells.
    Lim KG; Tonelli F; Li Z; Lu X; Bittman R; Pyne S; Pyne NJ
    J Biol Chem; 2011 May; 286(21):18633-40. PubMed ID: 21464128
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Molecular targets of FTY720 (fingolimod).
    Pitman MR; Woodcock JM; Lopez AF; Pitson SM
    Curr Mol Med; 2012 Dec; 12(10):1207-19. PubMed ID: 22834825
    [TBL] [Abstract][Full Text] [Related]  

  • 8. (R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells.
    Lim KG; Sun C; Bittman R; Pyne NJ; Pyne S
    Cell Signal; 2011 Oct; 23(10):1590-5. PubMed ID: 21620961
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2.
    Paugh SW; Payne SG; Barbour SE; Milstien S; Spiegel S
    FEBS Lett; 2003 Nov; 554(1-2):189-93. PubMed ID: 14596938
    [TBL] [Abstract][Full Text] [Related]  

  • 10. FTY720 (fingolimod) sensitizes prostate cancer cells to radiotherapy by inhibition of sphingosine kinase-1.
    Pchejetski D; Bohler T; Brizuela L; Sauer L; Doumerc N; Golzio M; Salunkhe V; Teissié J; Malavaud B; Waxman J; Cuvillier O
    Cancer Res; 2010 Nov; 70(21):8651-61. PubMed ID: 20959468
    [TBL] [Abstract][Full Text] [Related]  

  • 11. FTY720 (fingolimod) increases vascular tone and blood pressure in spontaneously hypertensive rats via inhibition of sphingosine kinase.
    Spijkers LJ; Alewijnse AE; Peters SL
    Br J Pharmacol; 2012 Jun; 166(4):1411-8. PubMed ID: 22251137
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Anticarcinogenic effect of FTY720 in human prostate carcinoma DU145 cells: modulation of mitogenic signaling, FAK, cell-cycle entry and apoptosis.
    Permpongkosol S; Wang JD; Takahara S; Matsumiya K; Nonomura N; Nishimura K; Tsujimura A; Kongkanand A; Okuyama A
    Int J Cancer; 2002 Mar; 98(2):167-72. PubMed ID: 11857403
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720.
    Zemann B; Kinzel B; Müller M; Reuschel R; Mechtcheriakova D; Urtz N; Bornancin F; Baumruker T; Billich A
    Blood; 2006 Feb; 107(4):1454-8. PubMed ID: 16223773
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Induction of apoptosis in human bladder cancer cells in vitro and in vivo caused by FTY720 treatment.
    Azuma H; Takahara S; Horie S; Muto S; Otsuki Y; Katsuoka Y
    J Urol; 2003 Jun; 169(6):2372-7. PubMed ID: 12771800
    [TBL] [Abstract][Full Text] [Related]  

  • 15. FTY720 inhibits ceramide synthases and up-regulates dihydrosphingosine 1-phosphate formation in human lung endothelial cells.
    Berdyshev EV; Gorshkova I; Skobeleva A; Bittman R; Lu X; Dudek SM; Mirzapoiazova T; Garcia JG; Natarajan V
    J Biol Chem; 2009 Feb; 284(9):5467-77. PubMed ID: 19119142
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The immune modulator FTY720 targets sphingosine-kinase-dependent migration of human monocytes in response to amyloid beta-protein and its precursor.
    Kaneider NC; Lindner J; Feistritzer C; Sturn DH; Mosheimer BA; Djanani AM; Wiedermann CJ
    FASEB J; 2004 Aug; 18(11):1309-11. PubMed ID: 15208267
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Essential requirement for sphingosine kinase 2 in a sphingolipid apoptosis pathway activated by FTY720 analogues.
    Don AS; Martinez-Lamenca C; Webb WR; Proia RL; Roberts E; Rosen H
    J Biol Chem; 2007 May; 282(21):15833-42. PubMed ID: 17400555
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor.
    Oo ML; Thangada S; Wu MT; Liu CH; Macdonald TL; Lynch KR; Lin CY; Hla T
    J Biol Chem; 2007 Mar; 282(12):9082-9. PubMed ID: 17237497
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinases.
    Billich A; Bornancin F; Dévay P; Mechtcheriakova D; Urtz N; Baumruker T
    J Biol Chem; 2003 Nov; 278(48):47408-15. PubMed ID: 13129923
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Sphingosine analog fingolimod (FTY720) increases radiation sensitivity of human breast cancer cells in vitro.
    Marvaso G; Barone A; Amodio N; Raimondi L; Agosti V; Altomare E; Scotti V; Lombardi A; Bianco R; Bianco C; Caraglia M; Tassone P; Tagliaferri P
    Cancer Biol Ther; 2014 Jun; 15(6):797-805. PubMed ID: 24657936
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.