These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

179 related articles for article (PubMed ID: 18521083)

  • 1. Activation of p53 by nutlin leads to rapid differentiation of human embryonic stem cells.
    Maimets T; Neganova I; Armstrong L; Lako M
    Oncogene; 2008 Sep; 27(40):5277-87. PubMed ID: 18521083
    [TBL] [Abstract][Full Text] [Related]  

  • 2. E2F-1 transcriptional activity is a critical determinant of Mdm2 antagonist-induced apoptosis in human tumor cell lines.
    Kitagawa M; Aonuma M; Lee SH; Fukutake S; McCormick F
    Oncogene; 2008 Sep; 27(40):5303-14. PubMed ID: 18521084
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Mdm2 is required for inhibition of Cdk2 activity by p21, thereby contributing to p53-dependent cell cycle arrest.
    Giono LE; Manfredi JJ
    Mol Cell Biol; 2007 Jun; 27(11):4166-78. PubMed ID: 17371838
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Molecular mechanisms of nutlin-induced apoptosis in multiple myeloma: evidence for p53-transcription-dependent and -independent pathways.
    Saha MN; Jiang H; Chang H
    Cancer Biol Ther; 2010 Sep; 10(6):567-78. PubMed ID: 20595817
    [TBL] [Abstract][Full Text] [Related]  

  • 5. MDM2 antagonist Nutlin-3 suppresses the proliferation and differentiation of human pre-osteoclasts through a p53-dependent pathway.
    Zauli G; Rimondi E; Corallini F; Fadda R; Capitani S; Secchiero P
    J Bone Miner Res; 2007 Oct; 22(10):1621-30. PubMed ID: 17592964
    [TBL] [Abstract][Full Text] [Related]  

  • 6. An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells.
    Neganova I; Vilella F; Atkinson SP; Lloret M; Passos JF; von Zglinicki T; O'Connor JE; Burks D; Jones R; Armstrong L; Lako M
    Stem Cells; 2011 Apr; 29(4):651-9. PubMed ID: 21319273
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Combination of nutlin-3 and VX-680 selectively targets p53 mutant cells with reversible effects on cells expressing wild-type p53.
    Cheok CF; Kua N; Kaldis P; Lane DP
    Cell Death Differ; 2010 Sep; 17(9):1486-500. PubMed ID: 20203688
    [TBL] [Abstract][Full Text] [Related]  

  • 8. MDM2 antagonist can inhibit tumor growth in hepatocellular carcinoma with different types of p53 in vitro.
    Wang J; Zheng T; Chen X; Song X; Meng X; Bhatta N; Pan S; Jiang H; Liu L
    J Gastroenterol Hepatol; 2011 Feb; 26(2):371-7. PubMed ID: 21261729
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Induction of p53-dependent senescence by the MDM2 antagonist nutlin-3a in mouse cells of fibroblast origin.
    Efeyan A; Ortega-Molina A; Velasco-Miguel S; Herranz D; Vassilev LT; Serrano M
    Cancer Res; 2007 Aug; 67(15):7350-7. PubMed ID: 17671205
    [TBL] [Abstract][Full Text] [Related]  

  • 10. HDM2 antagonist Nutlin-3 disrupts p73-HDM2 binding and enhances p73 function.
    Lau LM; Nugent JK; Zhao X; Irwin MS
    Oncogene; 2008 Feb; 27(7):997-1003. PubMed ID: 17700533
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Incompatible effects of p53 and HDAC inhibition on p21 expression and cell cycle progression.
    Sachweh MC; Drummond CJ; Higgins M; Campbell J; Laín S
    Cell Death Dis; 2013 Mar; 4(3):e533. PubMed ID: 23470540
    [TBL] [Abstract][Full Text] [Related]  

  • 12. TGF-beta-mediated cell cycle arrest of HPV16-immortalized human ectocervical cells correlates with decreased E6/E7 mRNA and increased p53 and p21(WAF-1) expression.
    Rorke EA; Zhang D; Choo CK; Eckert RL; Jacobberger JW
    Exp Cell Res; 2000 Aug; 259(1):149-57. PubMed ID: 10942587
    [TBL] [Abstract][Full Text] [Related]  

  • 13. MDM-2 antagonists induce p53-dependent cell cycle arrest but not cell death in renal cancer cell lines.
    Tsao CC; Corn PG
    Cancer Biol Ther; 2010 Dec; 10(12):1315-25. PubMed ID: 20953142
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Small molecule inhibition of HDM2 leads to p53-mediated cell death in retinoblastoma cells.
    Elison JR; Cobrinik D; Claros N; Abramson DH; Lee TC
    Arch Ophthalmol; 2006 Sep; 124(9):1269-75. PubMed ID: 16966622
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Nutlin-3 affects expression and function of retinoblastoma protein: role of retinoblastoma protein in cellular response to nutlin-3.
    Du W; Wu J; Walsh EM; Zhang Y; Chen CY; Xiao ZX
    J Biol Chem; 2009 Sep; 284(39):26315-21. PubMed ID: 19648117
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synergistic cytotoxic activity of recombinant TRAIL plus the non-genotoxic activator of the p53 pathway nutlin-3 in acute myeloid leukemia cells.
    Secchiero P; Zerbinati C; di Iasio MG; Melloni E; Tiribelli M; Grill V; Zauli G
    Curr Drug Metab; 2007 May; 8(4):395-403. PubMed ID: 17504227
    [TBL] [Abstract][Full Text] [Related]  

  • 17. MDM2 antagonist nutlin plus proteasome inhibitor velcade combination displays a synergistic anti-myeloma activity.
    Saha MN; Jiang H; Jayakar J; Reece D; Branch DR; Chang H
    Cancer Biol Ther; 2010 Jun; 9(11):936-44. PubMed ID: 20418664
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Nutlin-3 radiosensitizes hypoxic prostate cancer cells independent of p53.
    Supiot S; Hill RP; Bristow RG
    Mol Cancer Ther; 2008 Apr; 7(4):993-9. PubMed ID: 18413812
    [TBL] [Abstract][Full Text] [Related]  

  • 19. MDMX overexpression prevents p53 activation by the MDM2 inhibitor Nutlin.
    Hu B; Gilkes DM; Farooqi B; Sebti SM; Chen J
    J Biol Chem; 2006 Nov; 281(44):33030-5. PubMed ID: 16905541
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The multifunctional Ca2+/calmodulin-dependent kinase II delta (CaMKIIdelta) controls neointima formation after carotid ligation and vascular smooth muscle cell proliferation through cell cycle regulation by p21.
    Li W; Li H; Sanders PN; Mohler PJ; Backs J; Olson EN; Anderson ME; Grumbach IM
    J Biol Chem; 2011 Mar; 286(10):7990-7999. PubMed ID: 21193397
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.