390 related articles for article (PubMed ID: 18524979)
1. MF63 [2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a selective microsomal prostaglandin E synthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation.
Xu D; Rowland SE; Clark P; Giroux A; Côté B; Guiral S; Salem M; Ducharme Y; Friesen RW; Méthot N; Mancini J; Audoly L; Riendeau D
J Pharmacol Exp Ther; 2008 Sep; 326(3):754-63. PubMed ID: 18524979
[TBL] [Abstract][Full Text] [Related]
2. Dual, constrictor-to-dilator, response of the mouse ductus arteriosus to the microsomal prostaglandin E synthase-1 inhibitor, 2-(6-chloro-1H-phenanthro[9,10d]imidazole- 2-yl)isophthalonitrile.
Baragatti B; Scebba F; Sodini D; Pagni E; Ciofini E; Xu D; Coceani F
Neonatology; 2011; 100(2):139-46. PubMed ID: 21372596
[TBL] [Abstract][Full Text] [Related]
3. Identification and Characterization of Novel Microsomal Prostaglandin E Synthase-1 Inhibitors for Analgesia.
Chandrasekhar S; Harvey AK; Yu XP; Chambers MG; Oskins JL; Lin C; Seng TW; Thibodeaux SJ; Norman BH; Hughes NE; Schiffler MA; Fisher MJ
J Pharmacol Exp Ther; 2016 Mar; 356(3):635-44. PubMed ID: 26740668
[TBL] [Abstract][Full Text] [Related]
4. Distinction of microsomal prostaglandin E synthase-1 (mPGES-1) inhibition from cyclooxygenase-2 inhibition in cells using a novel, selective mPGES-1 inhibitor.
Mbalaviele G; Pauley AM; Shaffer AF; Zweifel BS; Mathialagan S; Mnich SJ; Nemirovskiy OV; Carter J; Gierse JK; Wang JL; Vazquez ML; Moore WM; Masferrer JL
Biochem Pharmacol; 2010 May; 79(10):1445-54. PubMed ID: 20067770
[TBL] [Abstract][Full Text] [Related]
5. MF498 [N-{[4-(5,9-Diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo[3,4-g]quinolin-7-yl)-3-methylbenzyl]sulfonyl}-2-(2-methoxyphenyl)acetamide], a selective E prostanoid receptor 4 antagonist, relieves joint inflammation and pain in rodent models of rheumatoid and osteoarthritis.
Clark P; Rowland SE; Denis D; Mathieu MC; Stocco R; Poirier H; Burch J; Han Y; Audoly L; Therien AG; Xu D
J Pharmacol Exp Ther; 2008 May; 325(2):425-34. PubMed ID: 18287210
[TBL] [Abstract][Full Text] [Related]
6. The molecular pharmacology and in vivo activity of 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS121), a dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.
Koeberle A; Rossi A; Zettl H; Pergola C; Dehm F; Bauer J; Greiner C; Reckel S; Hoernig C; Northoff H; Bernhard F; Dötsch V; Sautebin L; Schubert-Zsilavecz M; Werz O
J Pharmacol Exp Ther; 2010 Mar; 332(3):840-8. PubMed ID: 19934399
[TBL] [Abstract][Full Text] [Related]
7. Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors.
Côté B; Boulet L; Brideau C; Claveau D; Ethier D; Frenette R; Gagnon M; Giroux A; Guay J; Guiral S; Mancini J; Martins E; Massé F; Méthot N; Riendeau D; Rubin J; Xu D; Yu H; Ducharme Y; Friesen RW
Bioorg Med Chem Lett; 2007 Dec; 17(24):6816-20. PubMed ID: 18029174
[TBL] [Abstract][Full Text] [Related]
8. Effects of AF3442 [N-(9-ethyl-9H-carbazol-3-yl)-2-(trifluoromethyl)benzamide], a novel inhibitor of human microsomal prostaglandin E synthase-1, on prostanoid biosynthesis in human monocytes in vitro.
Bruno A; Di Francesco L; Coletta I; Mangano G; Alisi MA; Polenzani L; Milanese C; Anzellotti P; Ricciotti E; Dovizio M; Di Francesco A; Tacconelli S; Capone ML; Patrignani P
Biochem Pharmacol; 2010 Apr; 79(7):974-81. PubMed ID: 19925781
[TBL] [Abstract][Full Text] [Related]
9. Microsomal prostaglandin E synthase-1 is a major terminal synthase that is selectively up-regulated during cyclooxygenase-2-dependent prostaglandin E2 production in the rat adjuvant-induced arthritis model.
Claveau D; Sirinyan M; Guay J; Gordon R; Chan CC; Bureau Y; Riendeau D; Mancini JA
J Immunol; 2003 May; 170(9):4738-44. PubMed ID: 12707354
[TBL] [Abstract][Full Text] [Related]
10. Characterization of microsomal prostaglandin E synthase 1 inhibitors.
Korotkova M; Jakobsson PJ
Basic Clin Pharmacol Toxicol; 2014 Jan; 114(1):64-9. PubMed ID: 24138533
[TBL] [Abstract][Full Text] [Related]
11. Nonacidic inhibitors of human microsomal prostaglandin synthase 1 (mPGES 1) identified by a multistep virtual screening protocol.
Rörsch F; Wobst I; Zettl H; Schubert-Zsilavecz M; Grösch S; Geisslinger G; Schneider G; Proschak E
J Med Chem; 2010 Jan; 53(2):911-5. PubMed ID: 20025212
[TBL] [Abstract][Full Text] [Related]
12. Microsomal prostaglandin E2 synthase-1 (mPGES-1): a novel anti-inflammatory therapeutic target.
Friesen RW; Mancini JA
J Med Chem; 2008 Jul; 51(14):4059-67. PubMed ID: 18459759
[No Abstract] [Full Text] [Related]
13. Synthesis and pharmacological evaluation of a selected library of new potential anti-inflammatory agents bearing the gamma-hydroxybutenolide scaffold: a new class of inhibitors of prostanoid production through the selective modulation of microsomal prostaglandin E synthase-1 expression.
Guerrero MD; Aquino M; Bruno I; Terencio MC; Paya M; Riccio R; Gomez-Paloma L
J Med Chem; 2007 May; 50(9):2176-84. PubMed ID: 17407277
[TBL] [Abstract][Full Text] [Related]
14. Inhibition of microsomal prostaglandin E-synthase-1 (mPGES-1) selectively suppresses PGE
Martin EM; Jones SL
Vet Immunol Immunopathol; 2017 Oct; 192():33-40. PubMed ID: 29042013
[TBL] [Abstract][Full Text] [Related]
15. Biarylimidazoles as inhibitors of microsomal prostaglandin E2 synthase-1.
Wu TY; Juteau H; Ducharme Y; Friesen RW; Guiral S; Dufresne L; Poirier H; Salem M; Riendeau D; Mancini J; Brideau C
Bioorg Med Chem Lett; 2010 Dec; 20(23):6978-82. PubMed ID: 20965723
[TBL] [Abstract][Full Text] [Related]
16. Inhibitors of the microsomal prostaglandin E(2) synthase-1 as alternative to non steroidal anti-inflammatory drugs (NSAIDs)--a critical review.
Koeberle A; Werz O
Curr Med Chem; 2009; 16(32):4274-96. PubMed ID: 19754418
[TBL] [Abstract][Full Text] [Related]
17. A novel selective prostaglandin E2 synthesis inhibitor relieves pyrexia and arthritis in Guinea pigs inflammatory models.
Sugita R; Kubota K; Sugimoto K; Tachida Y; Shibayama T; Kiho T; Kawakami K; Shimada K
J Pharmacol Sci; 2016 Feb; 130(2):128-35. PubMed ID: 26906248
[TBL] [Abstract][Full Text] [Related]
18. Discovery of 2-((2-chloro-6-fluorophenyl)amino)-N-(3-fluoro-5-(trifluoromethyl)phenyl)-1-methyl-7,8-dihydro-1H-[1,4]dioxino[2',3':3,4]benzo[1,2-d]imidazole-5-carboxamide as potent, selective and efficacious microsomal prostaglandin E
Muthukaman N; Deshmukh S; Sarode N; Tondlekar S; Tambe M; Pisal D; Shaikh M; Kattige VG; Honnegowda S; Karande V; Kulkarni A; Jadhav SB; Mahat MYA; Gudi GS; Khairatkar-Joshi N; Gharat LA
Bioorg Med Chem Lett; 2016 Dec; 26(24):5977-5984. PubMed ID: 27865703
[TBL] [Abstract][Full Text] [Related]
19. Myrtucommulone, a natural acylphloroglucinol, inhibits microsomal prostaglandin E(2) synthase-1.
Koeberle A; Pollastro F; Northoff H; Werz O
Br J Pharmacol; 2009 Mar; 156(6):952-61. PubMed ID: 19298395
[TBL] [Abstract][Full Text] [Related]
20. Licofelone suppresses prostaglandin E2 formation by interference with the inducible microsomal prostaglandin E2 synthase-1.
Koeberle A; Siemoneit U; Bühring U; Northoff H; Laufer S; Albrecht W; Werz O
J Pharmacol Exp Ther; 2008 Sep; 326(3):975-82. PubMed ID: 18550688
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
