BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

469 related articles for article (PubMed ID: 18544649)

  • 1. The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma.
    Guillermet-Guibert J; Bjorklof K; Salpekar A; Gonella C; Ramadani F; Bilancio A; Meek S; Smith AJ; Okkenhaug K; Vanhaesebroeck B
    Proc Natl Acad Sci U S A; 2008 Jun; 105(24):8292-7. PubMed ID: 18544649
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Coincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3Kβ in myeloid cells.
    Houslay DM; Anderson KE; Chessa T; Kulkarni S; Fritsch R; Downward J; Backer JM; Stephens LR; Hawkins PT
    Sci Signal; 2016 Aug; 9(441):ra82. PubMed ID: 27531651
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Oncogenic signaling of class I PI3K isoforms.
    Denley A; Kang S; Karst U; Vogt PK
    Oncogene; 2008 Apr; 27(18):2561-74. PubMed ID: 17998941
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Class-IA phosphoinositide 3-kinase p110β Triggers GPCR-induced superoxide production in p110γ-deficient murine neutrophils.
    Nigorikawa K; Hazeki K; Kumazawa T; Itoh Y; Hoshi M; Hazeki O
    J Pharmacol Sci; 2012; 120(4):270-9. PubMed ID: 23149576
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Ligand-selective signal transduction by two endogenous GnRH isoforms involves biased activation of the class I PI3K catalytic subunits p110β, p110γ, and p110δ in pituitary gonadotropes and somatotropes.
    Pemberton JG; Stafford JL; Chang JP
    Endocrinology; 2015 Jan; 156(1):218-30. PubMed ID: 25343277
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Membrane localization of all class I PI 3-kinase isoforms suppresses c-Myc-induced apoptosis in Rat1 fibroblasts via Akt.
    Link W; Rosado A; Fominaya J; Thomas JE; Carnero A
    J Cell Biochem; 2005 Aug; 95(5):979-89. PubMed ID: 15838873
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Both p110α and p110β isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor.
    Berenjeno IM; Guillermet-Guibert J; Pearce W; Gray A; Fleming S; Vanhaesebroeck B
    Biochem J; 2012 Feb; 442(1):151-9. PubMed ID: 22150431
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Class I phosphoinositide 3-kinase p110beta is required for apoptotic cell and Fcgamma receptor-mediated phagocytosis by macrophages.
    Leverrier Y; Okkenhaug K; Sawyer C; Bilancio A; Vanhaesebroeck B; Ridley AJ
    J Biol Chem; 2003 Oct; 278(40):38437-42. PubMed ID: 12869549
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Recent patents of gene sequences relative to the phosphatidylinositol 3-kinase/Akt pathway and their relevance to drug discovery.
    Doepfner KT; Boller D; De Laurentiis A; Guerreiro AS; Marinov M; Arcaro A
    Recent Pat DNA Gene Seq; 2007; 1(1):9-23. PubMed ID: 19075915
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Activity of any class IA PI3K isoform can sustain cell proliferation and survival.
    Foukas LC; Berenjeno IM; Gray A; Khwaja A; Vanhaesebroeck B
    Proc Natl Acad Sci U S A; 2010 Jun; 107(25):11381-6. PubMed ID: 20534549
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Distinct roles of class IA PI3K isoforms in primary and immortalised macrophages.
    Papakonstanti EA; Zwaenepoel O; Bilancio A; Burns E; Nock GE; Houseman B; Shokat K; Ridley AJ; Vanhaesebroeck B
    J Cell Sci; 2008 Dec; 121(Pt 24):4124-33. PubMed ID: 19033389
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs.
    Rathinaswamy MK; Jenkins ML; Duewell BR; Zhang X; Harris NJ; Evans JT; Stariha JTB; Dalwadi U; Fleming KD; Ranga-Prasad H; Yip CK; Williams RL; Hansen SD; Burke JE
    Cell Rep; 2023 Mar; 42(3):112172. PubMed ID: 36842083
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A biochemical mechanism for the oncogenic potential of the p110beta catalytic subunit of phosphoinositide 3-kinase.
    Dbouk HA; Pang H; Fiser A; Backer JM
    Proc Natl Acad Sci U S A; 2010 Nov; 107(46):19897-902. PubMed ID: 21030680
    [TBL] [Abstract][Full Text] [Related]  

  • 14. PI3Kgamma adaptor subunits define coupling to degranulation and cell motility by distinct PtdIns(3,4,5)P3 pools in mast cells.
    Bohnacker T; Marone R; Collmann E; Calvez R; Hirsch E; Wymann MP
    Sci Signal; 2009 Jun; 2(74):ra27. PubMed ID: 19509406
    [TBL] [Abstract][Full Text] [Related]  

  • 15. RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms.
    Fritsch R; de Krijger I; Fritsch K; George R; Reason B; Kumar MS; Diefenbacher M; Stamp G; Downward J
    Cell; 2013 May; 153(5):1050-63. PubMed ID: 23706742
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration.
    Graupera M; Guillermet-Guibert J; Foukas LC; Phng LK; Cain RJ; Salpekar A; Pearce W; Meek S; Millan J; Cutillas PR; Smith AJ; Ridley AJ; Ruhrberg C; Gerhardt H; Vanhaesebroeck B
    Nature; 2008 May; 453(7195):662-6. PubMed ID: 18449193
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Phosphoinositide 3-kinases p110α and p110β have differential roles in insulin-like growth factor-1-mediated Akt phosphorylation and platelet priming.
    Blair TA; Moore SF; Williams CM; Poole AW; Vanhaesebroeck B; Hers I
    Arterioscler Thromb Vasc Biol; 2014 Aug; 34(8):1681-8. PubMed ID: 24903091
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A function for phosphoinositide 3-kinase beta lipid products in coupling beta gamma to Ras activation in response to lysophosphatidic acid.
    Yart A; Roche S; Wetzker R; Laffargue M; Tonks N; Mayeux P; Chap H; Raynal P
    J Biol Chem; 2002 Jun; 277(24):21167-78. PubMed ID: 11916960
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Phosphoinositide 3-kinase pathway activation in phosphate and tensin homolog (PTEN)-deficient prostate cancer cells is independent of receptor tyrosine kinases and mediated by the p110beta and p110delta catalytic subunits.
    Jiang X; Chen S; Asara JM; Balk SP
    J Biol Chem; 2010 May; 285(20):14980-14989. PubMed ID: 20231295
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma.
    Kurig B; Shymanets A; Bohnacker T; Prajwal ; Brock C; Ahmadian MR; Schaefer M; Gohla A; Harteneck C; Wymann MP; Jeanclos E; Nürnberg B
    Proc Natl Acad Sci U S A; 2009 Dec; 106(48):20312-7. PubMed ID: 19906996
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 24.