These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
3. Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell apoptosis. Chen J; Saxena G; Mungrue IN; Lusis AJ; Shalev A Diabetes; 2008 Apr; 57(4):938-44. PubMed ID: 18171713 [TBL] [Abstract][Full Text] [Related]
4. Lack of TXNIP protects against mitochondria-mediated apoptosis but not against fatty acid-induced ER stress-mediated beta-cell death. Chen J; Fontes G; Saxena G; Poitout V; Shalev A Diabetes; 2010 Feb; 59(2):440-7. PubMed ID: 19875615 [TBL] [Abstract][Full Text] [Related]
5. Lack of TXNIP protects beta-cells against glucotoxicity. Shalev A Biochem Soc Trans; 2008 Oct; 36(Pt 5):963-5. PubMed ID: 18793170 [TBL] [Abstract][Full Text] [Related]
6. Diabetes induces and calcium channel blockers prevent cardiac expression of proapoptotic thioredoxin-interacting protein. Chen J; Cha-Molstad H; Szabo A; Shalev A Am J Physiol Endocrinol Metab; 2009 May; 296(5):E1133-9. PubMed ID: 19258488 [TBL] [Abstract][Full Text] [Related]
7. W2476 ameliorates β-cell dysfunction and exerts therapeutic effects in mouse models of diabetes via modulation of the thioredoxin-interacting protein signaling pathway. Li T; Lin GY; Zhong L; Zhou Y; Wang J; Zhu Y; Feng Y; Cai XQ; Liu Q; Nosjean O; Boutin JA; Renard P; Yang DH; Wang MW Acta Pharmacol Sin; 2017 Jul; 38(7):1024-1037. PubMed ID: 28502980 [TBL] [Abstract][Full Text] [Related]
8. Preventing β-cell loss and diabetes with calcium channel blockers. Xu G; Chen J; Jing G; Shalev A Diabetes; 2012 Apr; 61(4):848-56. PubMed ID: 22442301 [TBL] [Abstract][Full Text] [Related]
9. Knockdown of thioredoxin interacting protein in Müller cells attenuates photoreceptor apoptosis in streptozotocin-induced diabetic mouse model. Li N; Gao S; Gao S; Wang Y; Huang H; Wang J; Shen X Int J Biol Macromol; 2024 Jun; 271(Pt 2):132731. PubMed ID: 38815945 [TBL] [Abstract][Full Text] [Related]
10. Cytokines Regulate β-Cell Thioredoxin-interacting Protein (TXNIP) via Distinct Mechanisms and Pathways. Hong K; Xu G; Grayson TB; Shalev A J Biol Chem; 2016 Apr; 291(16):8428-39. PubMed ID: 26858253 [TBL] [Abstract][Full Text] [Related]
11. Thioredoxin-interacting protein regulates insulin transcription through microRNA-204. Xu G; Chen J; Jing G; Shalev A Nat Med; 2013 Sep; 19(9):1141-6. PubMed ID: 23975026 [TBL] [Abstract][Full Text] [Related]
12. Thioredoxin-Interacting Protein Deficiency Protects against Diabetic Nephropathy. Shah A; Xia L; Masson EA; Gui C; Momen A; Shikatani EA; Husain M; Quaggin S; John R; Fantus IG J Am Soc Nephrol; 2015 Dec; 26(12):2963-77. PubMed ID: 25855771 [TBL] [Abstract][Full Text] [Related]
13. SIRT6-mediated transcriptional suppression of Txnip is critical for pancreatic beta cell function and survival in mice. Qin K; Zhang N; Zhang Z; Nipper M; Zhu Z; Leighton J; Xu K; Musi N; Wang P Diabetologia; 2018 Apr; 61(4):906-918. PubMed ID: 29322219 [TBL] [Abstract][Full Text] [Related]
14. Deletion of thioredoxin-interacting protein improves cardiac inotropic reserve in the streptozotocin-induced diabetic heart. Myers RB; Fomovsky GM; Lee S; Tan M; Wang BF; Patwari P; Yoshioka J Am J Physiol Heart Circ Physiol; 2016 Jun; 310(11):H1748-59. PubMed ID: 27037370 [TBL] [Abstract][Full Text] [Related]
15. TXNIP, a novel key factor to cause Schwann cell dysfunction in diabetic peripheral neuropathy, under the regulation of PI3K/Akt pathway inhibition-induced DNMT1 and DNMT3a overexpression. Zhang X; Zhao S; Yuan Q; Zhu L; Li F; Wang H; Kong D; Hao J Cell Death Dis; 2021 Jun; 12(7):642. PubMed ID: 34162834 [TBL] [Abstract][Full Text] [Related]
16. Insulin counteracts glucotoxic effects by suppressing thioredoxin-interacting protein production in INS-1E beta cells and in Psammomys obesus pancreatic islets. Shaked M; Ketzinel-Gilad M; Ariav Y; Cerasi E; Kaiser N; Leibowitz G Diabetologia; 2009 Apr; 52(4):636-44. PubMed ID: 19214472 [TBL] [Abstract][Full Text] [Related]
17. Thioredoxin-interacting protein is stimulated by glucose through a carbohydrate response element and induces beta-cell apoptosis. Minn AH; Hafele C; Shalev A Endocrinology; 2005 May; 146(5):2397-405. PubMed ID: 15705778 [TBL] [Abstract][Full Text] [Related]
18. Endogenous hydrogen sulfide protects pancreatic beta-cells from a high-fat diet-induced glucotoxicity and prevents the development of type 2 diabetes. Okamoto M; Yamaoka M; Takei M; Ando T; Taniguchi S; Ishii I; Tohya K; Ishizaki T; Niki I; Kimura T Biochem Biophys Res Commun; 2013 Dec; 442(3-4):227-33. PubMed ID: 24246677 [TBL] [Abstract][Full Text] [Related]
19. Intracellular shuttling and mitochondrial function of thioredoxin-interacting protein. Saxena G; Chen J; Shalev A J Biol Chem; 2010 Feb; 285(6):3997-4005. PubMed ID: 19959470 [TBL] [Abstract][Full Text] [Related]
20. Alpha Cell Thioredoxin-interacting Protein Deletion Improves Diabetes-associated Hyperglycemia and Hyperglucagonemia. Lu B; Chen J; Xu G; Grayson TB; Jing G; Jo S; Shalev A Endocrinology; 2022 Oct; 163(11):. PubMed ID: 35957590 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]