392 related articles for article (PubMed ID: 18553955)
1. Discovery of novel, potent benzamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) exhibiting oral activity in an enzyme inhibition ex vivo model.
Julian LD; Wang Z; Bostick T; Caille S; Choi R; DeGraffenreid M; Di Y; He X; Hungate RW; Jaen JC; Liu J; Monshouwer M; McMinn D; Rew Y; Sudom A; Sun D; Tu H; Ursu S; Walker N; Yan X; Ye Q; Powers JP
J Med Chem; 2008 Jul; 51(13):3953-60. PubMed ID: 18553955
[TBL] [Abstract][Full Text] [Related]
2. Synthesis and optimization of novel 4,4-disubstituted cyclohexylbenzamide derivatives as potent 11β-HSD1 inhibitors.
Sun D; Wang Z; Caille S; DeGraffenreid M; Gonzalez-Lopez de Turiso F; Hungate R; Jaen JC; Jiang B; Julian LD; Kelly R; McMinn DL; Kaizerman J; Rew Y; Sudom A; Tu H; Ursu S; Walker N; Willcockson M; Yan X; Ye Q; Powers JP
Bioorg Med Chem Lett; 2011 Jan; 21(1):405-10. PubMed ID: 21093258
[TBL] [Abstract][Full Text] [Related]
3. Synthesis and optimization of arylsulfonylpiperazines as a novel class of inhibitors of 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1).
Sun D; Wang Z; Cardozo M; Choi R; Degraffenreid M; Di Y; He X; Jaen JC; Labelle M; Liu J; Ma J; Miao S; Sudom A; Tang L; Tu H; Ursu S; Walker N; Yan X; Ye Q; Powers JP
Bioorg Med Chem Lett; 2009 Mar; 19(5):1522-7. PubMed ID: 19181519
[TBL] [Abstract][Full Text] [Related]
4. Discovery of adamantyl ethanone derivatives as potent 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitors.
Su X; Pradaux-Caggiano F; Thomas MP; Szeto MW; Halem HA; Culler MD; Vicker N; Potter BV
ChemMedChem; 2010 Jul; 5(7):1026-44. PubMed ID: 20486152
[TBL] [Abstract][Full Text] [Related]
5. Discovery and initial SAR of arylsulfonylpiperazine inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1).
Sun D; Wang Z; Di Y; Jaen JC; Labelle M; Ma J; Miao S; Sudom A; Tang L; Tomooka CS; Tu H; Ursu S; Walker N; Yan X; Ye Q; Powers JP
Bioorg Med Chem Lett; 2008 Jun; 18(12):3513-6. PubMed ID: 18511278
[TBL] [Abstract][Full Text] [Related]
6. Discovery and optimization of piperidyl benzamide derivatives as a novel class of 11beta-HSD1 inhibitors.
Rew Y; McMinn DL; Wang Z; He X; Hungate RW; Jaen JC; Sudom A; Sun D; Tu H; Ursu S; Villemure E; Walker NP; Yan X; Ye Q; Powers JP
Bioorg Med Chem Lett; 2009 Mar; 19(6):1797-801. PubMed ID: 19217779
[TBL] [Abstract][Full Text] [Related]
7. Optimization of novel di-substituted cyclohexylbenzamide derivatives as potent 11 beta-HSD1 inhibitors.
McMinn DL; Rew Y; Sudom A; Caille S; Degraffenreid M; He X; Hungate R; Jiang B; Jaen J; Julian LD; Kaizerman J; Novak P; Sun D; Tu H; Ursu S; Walker NP; Yan X; Ye Q; Wang Z; Powers JP
Bioorg Med Chem Lett; 2009 Mar; 19(5):1446-50. PubMed ID: 19185488
[TBL] [Abstract][Full Text] [Related]
8. Discovery of novel inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 by docking and pharmacophore modeling.
Yang H; Dou W; Lou J; Leng Y; Shen J
Bioorg Med Chem Lett; 2008 Feb; 18(4):1340-5. PubMed ID: 18242087
[TBL] [Abstract][Full Text] [Related]
9. 2-amino-1,3-thiazol-4(5H)-ones as potent and selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: enzyme-ligand co-crystal structure and demonstration of pharmacodynamic effects in C57Bl/6 mice.
Johansson L; Fotsch C; Bartberger MD; Castro VM; Chen M; Emery M; Gustafsson S; Hale C; Hickman D; Homan E; Jordan SR; Komorowski R; Li A; McRae K; Moniz G; Matsumoto G; Orihuela C; Palm G; Veniant M; Wang M; Williams M; Zhang J
J Med Chem; 2008 May; 51(10):2933-43. PubMed ID: 18419108
[TBL] [Abstract][Full Text] [Related]
10. Discovery and structure-activity relationships of pentanedioic acid diamides as potent inhibitors of 11beta-hydroxysteroid dehydrogenase type I.
Roche D; Carniato D; Leriche C; Lepifre F; Christmann-Franck S; Graedler U; Charon C; Bozec S; Doare L; Schmidlin F; Lecomte M; Valeur E
Bioorg Med Chem Lett; 2009 May; 19(10):2674-8. PubMed ID: 19395260
[TBL] [Abstract][Full Text] [Related]
11. Structural characterization and pharmacodynamic effects of an orally active 11beta-hydroxysteroid dehydrogenase type 1 inhibitor.
Hale C; Véniant M; Wang Z; Chen M; McCormick J; Cupples R; Hickman D; Min X; Sudom A; Xu H; Matsumoto G; Fotsch C; St Jean DJ; Wang M
Chem Biol Drug Des; 2008 Jan; 71(1):36-44. PubMed ID: 18069989
[TBL] [Abstract][Full Text] [Related]
12. 2-(S)-phenethylaminothiazolones as potent, orally efficacious inhibitors of 11beta-hydroxysteriod dehydrogenase type 1.
Jean DJ; Yuan C; Bercot EA; Cupples R; Chen M; Fretland J; Hale C; Hungate RW; Komorowski R; Veniant M; Wang M; Zhang X; Fotsch C
J Med Chem; 2007 Feb; 50(3):429-32. PubMed ID: 17266194
[TBL] [Abstract][Full Text] [Related]
13. Piperazine sulfonamides as potent, selective, and orally available 11beta-hydroxysteroid dehydrogenase type 1 inhibitors with efficacy in the rat cortisone-induced hyperinsulinemia model.
Xiang J; Wan ZK; Li HQ; Ipek M; Binnun E; Nunez J; Chen L; McKew JC; Mansour TS; Xu X; Suri V; Tam M; Xing Y; Li X; Hahm S; Tobin J; Saiah E
J Med Chem; 2008 Jul; 51(14):4068-71. PubMed ID: 18578516
[TBL] [Abstract][Full Text] [Related]
14. Phenylcyclobutyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I.
Zhu Y; Olson SH; Graham D; Patel G; Hermanowski-Vosatka A; Mundt S; Shah K; Springer M; Thieringer R; Wright S; Xiao J; Zokian H; Dragovic J; Balkovec JM
Bioorg Med Chem Lett; 2008 Jun; 18(11):3412-6. PubMed ID: 18440812
[TBL] [Abstract][Full Text] [Related]
15. Synthesis and 11β hydroxysteroid dehydrogenase 1 inhibition of thiazolidine derivatives with an adamantyl group.
Kwon SW; Kang SK; Lee JH; Bok JH; Kim CH; Dal Rhee S; Jung WH; Kim HY; Bae MA; Song JS; Ha DC; Cheon HG; Kim KY; Ahn JH
Bioorg Med Chem Lett; 2011 Jan; 21(1):435-9. PubMed ID: 21093259
[TBL] [Abstract][Full Text] [Related]
16. The synthesis and SAR of novel diarylsulfone 11β-HSD1 inhibitors.
Yan X; Wang Z; Sudom A; Cardozo M; DeGraffenreid M; Di Y; Fan P; He X; Jaen JC; Labelle M; Liu J; Ma J; McMinn D; Miao S; Sun D; Tang L; Tu H; Ursu S; Walker N; Ye Q; Powers JP
Bioorg Med Chem Lett; 2010 Dec; 20(23):7071-5. PubMed ID: 20971000
[TBL] [Abstract][Full Text] [Related]
17. Azabicyclic sulfonamides as potent 11beta-HSD1 inhibitors.
Shah U; Boyle CD; Chackalamannil S; Baker H; Kowalski T; Lee J; Terracina G; Zhang L
Bioorg Med Chem Lett; 2010 Mar; 20(5):1551-4. PubMed ID: 20149650
[TBL] [Abstract][Full Text] [Related]
18. The discovery of azepane sulfonamides as potent 11beta-HSD1 inhibitors.
Neelamkavil SF; Boyle CD; Chackalamannil S; Greenlee WJ; Zhang L; Terracina G
Bioorg Med Chem Lett; 2009 Aug; 19(16):4563-5. PubMed ID: 19625185
[TBL] [Abstract][Full Text] [Related]
19. The discovery of new 11beta-hydroxysteroid dehydrogenase type 1 inhibitors by common feature pharmacophore modeling and virtual screening.
Schuster D; Maurer EM; Laggner C; Nashev LG; Wilckens T; Langer T; Odermatt A
J Med Chem; 2006 Jun; 49(12):3454-66. PubMed ID: 16759088
[TBL] [Abstract][Full Text] [Related]
20. Pyrrolidine-pyrazole ureas as potent and selective inhibitors of 11β-hydroxysteroid-dehydrogenase type 1.
Venier O; Pascal C; Braun A; Namane C; Mougenot P; Crespin O; Pacquet F; Mougenot C; Monseau C; Onofri B; Dadji-Faïhun R; Leger C; Ben-Hassine M; Van-Pham T; Ragot JL; Philippo C; Güssregen S; Engel C; Farjot G; Noah L; Maniani K; Nicolaï E
Bioorg Med Chem Lett; 2011 Apr; 21(8):2244-51. PubMed ID: 21439819
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]